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Defb43 Gene Detail
Summary
  • Symbol
    Defb43
  • Name
    defensin beta 43
  • Synonyms
    EG654458
  • Feature Type
    protein coding gene
  • IDs
    MGI:3647180
    NCBI Gene: 654458
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:63249220-63255537 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 33.23 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    276 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3647180
 protein coding gene Chr14:63249220-63255537 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021453
 protein coding gene Chr14:57490442-57497688 (+)
A/J MGP_AJ_G0021412
 protein coding gene Chr14:56201987-56208420 (+)
AKR/J MGP_AKRJ_G0021388
 protein coding gene Chr14:58205897-58217135 (+)
BALB/cJ MGP_BALBcJ_G0021418
 protein coding gene Chr14:56157476-56163884 (+)
C3H/HeJ MGP_C3HHeJ_G0021195
 protein coding gene Chr14:57826381-57832501 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021857
 protein coding gene Chr14:60239859-60248006 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019397
 protein coding gene Chr14:54162032-54170137 (+)
CAST/EiJ MGP_CASTEiJ_G0020712
 protein coding gene Chr14:54274919-54282806 (+)
CBA/J MGP_CBAJ_G0021162
 protein coding gene Chr14:62023255-62031641 (+)
DBA/2J MGP_DBA2J_G0021285
 protein coding gene Chr14:55857317-55863686 (+)
FVB/NJ MGP_FVBNJ_G0021264
 protein coding gene Chr14:55278219-55284730 (+)
LP/J MGP_LPJ_G0021360
 protein coding gene Chr14:58520527-58528997 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021293
 protein coding gene Chr14:61298148-61305974 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021880
 protein coding gene Chr14:57352378-57359426 (+)
PWK/PhJ MGP_PWKPhJ_G0020456
 protein coding gene Chr14:52546661-52552657 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020289
 protein coding gene Chr14:53332516-53339242 (+)
WSB/EiJ MGP_WSBEiJ_G0020765
 protein coding gene Chr14:57671363-57677436 (+)



Homology
more
  • Human Ortholog
    DEFB131A, defensin beta 131A
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DEFB131A, defensin beta 131A
  • Synonyms
    DEFB131, DEFB-31
  • Links
    NCBI Gene ID: 644414
    neXtProt AC: NX_P59861
    UniProt: P59861

  • Chr Location
    4p16.1
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    5
  • GO References
    5
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    4
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 654458 NCBI Gene Model | MGI Sequence Detail 6318 C57BL/6J ±  kb
transcript NM_001039121 RefSeq | MGI Sequence Detail 418 Not Specified  
polypeptide Q30KM9 UniProt | EBI | MGI Sequence Detail 69 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    1 Sequence
  • InterPro Domains
    IPR025933 Beta-defensin
Molecular
Reagents
less
  • All nucleic 4
    cDNA 4

    Microarray probesets 1
References
more
  • Summaries
    All 26
    Gene Ontology 5
    Phenotypes 10
  • Earliest
    J:162220 Magdaleno S, et al., BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. PLoS Biol. 2006 Apr;4(4):e86
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory