About   Help   FAQ
Fam181a Gene Detail
Summary
  • Symbol
    Fam181a
  • Name
    family with sequence similarity 181, member A
  • Synonyms
    EG544888
  • Feature Type
    protein coding gene
  • IDs
    MGI:3647570
    NCBI Gene: 100504156
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:103277272-103283326 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 52.90 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    267 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3647570
 protein coding gene Chr12:103277234-103283326 (+)
129S1/SvImJ MGP_129S1SvImJ_G0020045
 protein coding gene Chr12:104989703-104995792 (+)
A/J MGP_AJ_G0020001
 protein coding gene Chr12:100952119-100958207 (+)
AKR/J MGP_AKRJ_G0019977
 protein coding gene Chr12:103798862-103804951 (+)
BALB/cJ MGP_BALBcJ_G0019987
 protein coding gene Chr12:101307682-101313776 (+)
C3H/HeJ MGP_C3HHeJ_G0019789
 protein coding gene Chr12:104290328-104296418 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020436
 protein coding gene Chr12:108244837-108250928 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018049
 protein coding gene Chr12:97992558-97998580 (+)
CAST/EiJ MGP_CASTEiJ_G0019335
 protein coding gene Chr12:99140538-99148225 (+)
CBA/J MGP_CBAJ_G0019761
 protein coding gene Chr12:112274090-112280179 (+)
DBA/2J MGP_DBA2J_G0019872
 protein coding gene Chr12:100471409-100477498 (+)
FVB/NJ MGP_FVBNJ_G0019861
 protein coding gene Chr12:99206721-99212812 (+)
LP/J MGP_LPJ_G0019948
 protein coding gene Chr12:104836652-104842741 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019901
 protein coding gene Chr12:115728764-115735332 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020465
 protein coding gene Chr12:103336603-103342693 (+)
PWK/PhJ MGP_PWKPhJ_G0019098
 protein coding gene Chr12:95033634-95039746 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018894
 protein coding gene Chr12:97536053-97542071 (+)
WSB/EiJ MGP_WSBEiJ_G0019389
 protein coding gene Chr12:104221700-104227789 (+)



Homology
more
  • Human Ortholog
    FAM181A, family with sequence similarity 181 member A
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FAM181A, family with sequence similarity 181 member A
  • Synonyms
    C14orf152
  • Links
    NCBI Gene ID: 90050
    neXtProt AC: NX_Q8N9Y4
    UniProt: Q8N9Y4

  • Chr Location
    14q32.12; chr14:93918894-93929608 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    3 phenotype references
  • All Mutations and Alleles
    2
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    1
  • Genomic Mutations
    1 involving Fam181a
  • Find Mice (IMSR)
    11 strains or lines available
Male mice homozygous for a null allele exhibit normal fertility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    1
  • GO References
    1
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    798
  • Tissues
    42
  • cDNA Data
    1
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 100504156 NCBI Gene Model | MGI Sequence Detail 6055 C57BL/6J ±  kb
transcript NM_001413260 RefSeq | MGI Sequence Detail 1418 C57BL/6  
polypeptide NP_001400191 RefSeq | MGI Sequence Detail 292 C57BL/6  
For the selected sequence
Protein
Information
less
  • UniProt
    2 Sequences
  • InterPro Domains
    IPR029359 FAM181
Molecular
Reagents
less
  • All nucleic 2
    cDNA 1
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGI:2144900
References
more
  • Summaries
    All 17
    Developmental Gene Expression 1
    Gene Ontology 1
    Phenotypes 3
  • Earliest
    J:228526 Marks M, et al., Analysis of the Fam181 gene family during mouse development reveals distinct strain-specific expression patterns, suggesting a role in nervous system development and function. Gene. 2016 Jan 10;575(2 Pt 2):438-51
  • Latest
    J:324697 Shah W, et al., Knockout of the family with sequence similarity 181, member A (Fam181a) gene does not impair spermatogenesis or male fertility in the mouse. Reprod Fertil Dev. 2021 Jul 13;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory