About   Help   FAQ
Hectd4 Gene Detail
Summary
  • Symbol
    Hectd4
  • Name
    HECT domain E3 ubiquitin protein ligase 4
  • Synonyms
    Gm15800, mKIAA0614
  • Feature Type
    protein coding gene
  • IDs
    MGI:3647820
    NCBI Gene: 269700
  • Alliance
    gene page
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:121358282-121506640 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 61.72 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2972 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3647820
 protein coding gene Chr5:121357323-121506640 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030024
 protein coding gene Chr5:124680628-124843772 (+)
A/J MGP_AJ_G0029989
 protein coding gene Chr5:119557973-119709445 (+)
AKR/J MGP_AKRJ_G0029926
 protein coding gene Chr5:123415753-123583524 (+)
BALB/cJ MGP_BALBcJ_G0030000
 protein coding gene Chr5:120941626-121092904 (+)
C3H/HeJ MGP_C3HHeJ_G0029718
 protein coding gene Chr5:123988595-124144575 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030453
 protein coding gene Chr5:129433645-129604011 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027679
 protein coding gene Chr5:114235902-114388148 (+)
CAST/EiJ MGP_CASTEiJ_G0029126
 protein coding gene Chr5:123090506-123257498 (+)
CBA/J MGP_CBAJ_G0029687
 protein coding gene Chr5:134513779-134684011 (+)
DBA/2J MGP_DBA2J_G0029837
 protein coding gene Chr5:119631235-119781341 (+)
FVB/NJ MGP_FVBNJ_G0029794
 protein coding gene Chr5:118574429-118728311 (+)
LP/J MGP_LPJ_G0029926
 protein coding gene Chr5:125207154-125368305 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029824
 protein coding gene Chr5:138400086-138567235 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030494
 protein coding gene Chr5:122922586-123092132 (+)
PWK/PhJ MGP_PWKPhJ_G0028840
 protein coding gene Chr5:118391441-118548117 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028677
 protein coding gene Chr5:120688649-120854732 (+)
WSB/EiJ MGP_WSBEiJ_G0029201
 protein coding gene Chr5:123593853-123752739 (+)



Homology
more
  • Human Ortholog
    HECTD4, HECT domain E3 ubiquitin protein ligase 4
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HECTD4, HECT domain E3 ubiquitin protein ligase 4
  • Synonyms
    C12ord51, C12orf51, HEEL, NEDSSCC, POTAGE
  • Links
    NCBI Gene ID: 283450
    UniProt: Q9Y4D8

  • Chr Location
    12q24.13; chr12:112160188-112382439 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    3
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    912
  • Tissues
    27
  • cDNA Data
    19
  • Literature Summary
    3
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000042744 Ensembl Gene Model | MGI Sequence Detail 148359 C57BL/6J ±  kb
transcript ENSMUST00000042614 Ensembl | MGI Sequence Detail 15482 Not Applicable  
polypeptide ENSMUSP00000048345 Ensembl | MGI Sequence Detail 4418 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 20
    cDNA 19
    Primer pair 1

    Microarray probesets 5
Other
Accession IDs
less
MGI:2141089, MGI:2448534, MGI:5896319
References
more
  • Summaries
    All 33
    Developmental Gene Expression 3
    Gene Ontology 2
    Phenotypes 9
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory