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Tnrc18 Gene Detail
Summary
  • Symbol
    Tnrc18
  • Name
    trinucleotide repeat containing 18
  • Synonyms
    EG381742, MGC:59613, Zfp469
  • Feature Type
    protein coding gene
  • IDs
    MGI:3648294
    NCBI Gene: 231861
  • Alliance
    gene page
  • Transcription Start Sites
    17 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:142710416-142803417 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 81.73 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2340 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3648294
 protein coding gene Chr5:142710357-142812386 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030317
 protein coding gene Chr5:147998449-148105612 (-)
A/J MGP_AJ_G0030286
 protein coding gene Chr5:141652554-141747101 (-)
AKR/J MGP_AKRJ_G0030218
 protein coding gene Chr5:146061435-146157658 (-)
BALB/cJ MGP_BALBcJ_G0030303
 protein coding gene Chr5:142891860-142986523 (-)
C3H/HeJ MGP_C3HHeJ_G0030014
 protein coding gene Chr5:146893716-146989977 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030748
 protein coding gene Chr5:153400167-153504476 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027966
 protein coding gene Chr5:135461721-135555760 (-)
CAST/EiJ MGP_CASTEiJ_G0029419
 protein coding gene Chr5:146355002-146462878 (-)
CBA/J MGP_CBAJ_G0029984
 protein coding gene Chr5:159679514-159791580 (-)
DBA/2J MGP_DBA2J_G0030134
 protein coding gene Chr5:141419646-141512848 (-)
FVB/NJ MGP_FVBNJ_G0030089
 protein coding gene Chr5:140615042-140712744 (-)
LP/J MGP_LPJ_G0030220
 protein coding gene Chr5:148605927-148703767 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030120
 protein coding gene Chr5:162167742-162278936 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030788
 protein coding gene Chr5:145916220-146021233 (-)
PWK/PhJ MGP_PWKPhJ_G0029134
 protein coding gene Chr5:140493462-140588809 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028970
 protein coding gene Chr5:143676010-143775860 (-)
WSB/EiJ MGP_WSBEiJ_G0029493
 protein coding gene Chr5:146713863-146812948 (-)



Homology
more
  • Human Ortholog
    TNRC18, trinucleotide repeat containing 18
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TNRC18, trinucleotide repeat containing 18
  • Synonyms
    CAGL79, TNRC18A
  • Links
    NCBI Gene ID: 84629
    neXtProt AC: NX_O15417
    UniProt: O15417

  • Chr Location
    7p22.1; chr7:5306790-5425414 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygosity for a H3K9me3-binding-defective mutation causes highly penetrant embryonic death and dwarfism in surviving mice.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    5
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000039477 Ensembl Gene Model | MGI Sequence Detail 93002 C57BL/6J ±  kb
    transcript ENSMUST00000152247 Ensembl | MGI Sequence Detail 9342 Not Applicable  
    polypeptide ENSMUSP00000117651 Ensembl | MGI Sequence Detail 2673 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000032010 trinucleotide repeat-containing gene 18 protein
      (term hierarchy)
    • InterPro Domains
      IPR048924 BAHCC1-like, Tudor domain
      IPR052429 BAH domain-containing protein
      IPR001025 Bromo adjacent homology (BAH) domain
      IPR043151 Bromo adjacent homology (BAH) domain superfamily
    • GlyGen
      Q80WC3 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 11
      Genomic 2
      cDNA 9

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:2448535
    References
    more
    • Summaries
      All 26
      Gene Ontology 2
      Phenotypes 6
    • Earliest
      J:82808 Strausberg RL, et al., Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903
    • Latest
      J:342966 Zhao S, et al., TNRC18 engages H3K9me3 to mediate silencing of endogenous retrotransposons. Nature. 2023 Nov;623(7987):633-642
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory