Prr19 MGI Mouse Gene Detail - MGI:3648539

Symbol

Prr19
Name

proline rich 19
Synonyms

EG623131

Feature Type

protein coding gene
IDs

MGI:3648539
NCBI Gene: 623131
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr7:25000836-25003557 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 13.74 cM
Mapping Data

1 experiment

SNPs within 2kb

128 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3648539	protein coding gene	Chr7:25000784-25003565 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0031861	protein coding gene	Chr7:23756311-23759033 (+)
A/J	MGP_AJ_G0031840	protein coding gene	Chr7:23147670-23150391 (+)
AKR/J	MGP_AKRJ_G0031769	protein coding gene	Chr7:23689110-23691831 (+)
BALB/cJ	MGP_BALBcJ_G0031847	protein coding gene	Chr7:23361303-23364024 (+)
C3H/HeJ	MGP_C3HHeJ_G0031566	protein coding gene	Chr7:24124549-24127270 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0032309	protein coding gene	Chr7:24551966-24554687 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0029364	protein coding gene	Chr7:24569307-24572026 (+)
CAST/EiJ	MGP_CASTEiJ_G0030906	protein coding gene	Chr7:17593526-17596251 (+)
CBA/J	MGP_CBAJ_G0031531	protein coding gene	Chr7:25468353-25471074 (+)
DBA/2J	MGP_DBA2J_G0031685	protein coding gene	Chr7:23048997-23051718 (+)
FVB/NJ	MGP_FVBNJ_G0031638	protein coding gene	Chr7:23051036-23053757 (+)
LP/J	MGP_LPJ_G0031764	protein coding gene	Chr7:24062568-24065290 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0031675	protein coding gene	Chr7:25171729-25174451 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0032341	protein coding gene	Chr7:23396575-23399296 (+)
PWK/PhJ	MGP_PWKPhJ_G0030630	protein coding gene	Chr7:17988563-17991376 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0030461	protein coding gene	Chr7:14710225-14712970 (+)
WSB/EiJ	MGP_WSBEiJ_G0031009	protein coding gene	Chr7:23573955-23576676 (+)

Human Ortholog

PRR19, proline rich 19

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PRR19, proline rich 19
Links

HGNC:33728

NCBI Gene ID: 284338

neXtProt AC: NX_A6NJB7

UniProt: A6NJB7
Chr Location

19q13.2; chr19:42302098-42310814 (+) GRCh38

MGI Vertebrate Homology

Prr19 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: PRR19
Gene Tree

Prr19

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Phenotype Summary

10 phenotypes from 2 alleles in 1 genetic background
3 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Endonuclease-mediated

2
Gene trapped

1
Targeted

1
Find Mice (IMSR)

7 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit female and male infertility due to defects in crossing over and double-strand break repair.

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All GO Annotations

3
GO References

2

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

8

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas

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All Sequences

33
RefSeq

6
UniProt

1
CCDS

CCDS52147.1

Ensembl

ENSMUSG00000058741 (Evidence)
NCBI Gene

623131

			Length	Strain/Species	Flank
genomic	ENSMUSG00000058741	Ensembl Gene Model \| MGI Sequence Detail	2722	C57BL/6J	± kb
transcript	ENSMUST00000080288	Ensembl \| MGI Sequence Detail	1240	Not Applicable
polypeptide	ENSMUSP00000104047	Ensembl \| MGI Sequence Detail	366	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000013305 proline-rich protein 19

(term hierarchy)
InterPro Domains

IPR029355 Proline-rich protein 19

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All nucleic 8

cDNA 8

Microarray probesets 1

Summaries

All 16

Gene Ontology 2

Phenotypes 3
Earliest

J:292293 Bondarieva A, et al., Proline-rich protein PRR19 functions with cyclin-like CNTD1 to promote meiotic crossing over in mouse. Nat Commun. 2020 Jun 18;11(1):3101

TSS for Prr19:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr65112	Chr7:25000768-25000787 (+)	-58 bp
Tssr65113	Chr7:25000791-25000805 (+)	-38 bp
Tssr65114	Chr7:25000841-25000846 (+)	8 bp
Tssr2140	Chr7:25000893-25000896 (+)	59 bp
Tssr65115	Chr7:25000901-25000949 (+)	89 bp
Tssr65116	Chr7:25000953-25000965 (+)	123 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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