Ces1a MGI Mouse Gene Detail - MGI:3648919

Symbol

Ces1a
Name

carboxylesterase 1A
Synonyms

Gm4976

Feature Type

protein coding gene
IDs

MGI:3648919
NCBI Gene: 244595
Member of

Ces1 cluster
Alliance

gene page

Sequence Map

Chr8:93746842-93774820 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 44.99 cM
Mapping Data

1 experiment

SNPs within 2kb

995 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3648919	protein coding gene	Chr8:93746842-93774820 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0033940	protein coding gene	Chr8:94344830-94371669 (-)
A/J	MGP_AJ_G0033923	protein coding gene	Chr8:90627949-90654896 (-)
AKR/J	MGP_AKRJ_G0033849	protein coding gene	Chr8:93174016-93200856 (-)
BALB/cJ	MGP_BALBcJ_G0033915	protein coding gene	Chr8:90782555-90809391 (-)
C3H/HeJ	MGP_C3HHeJ_G0033625	protein coding gene	Chr8:93890494-93917332 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0034436	protein coding gene	Chr8:97813239-97842020 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031377	protein coding gene	Chr8:84552567-84580028 (-)
CAST/EiJ	MGP_CASTEiJ_G0032957	protein coding gene	Chr8:93451751-93479964 (-)
CBA/J	MGP_CBAJ_G0033601	protein coding gene	Chr8:101068543-101095376 (-)
DBA/2J	MGP_DBA2J_G0033755	protein coding gene	Chr8:90168116-90195213 (-)
FVB/NJ	MGP_FVBNJ_G0033702	protein coding gene	Chr8:89108082-89134903 (-)
LP/J	MGP_LPJ_G0033847	protein coding gene	Chr8:94464555-94491439 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033744	protein coding gene	Chr8:103417535-103444277 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0034454	protein coding gene	Chr8:93291958-93318790 (-)
PWK/PhJ	MGP_PWKPhJ_G0032659	protein coding gene	Chr8:89516909-89545089 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0032496	protein coding gene	Chr8:92142544-92172071 (-)
WSB/EiJ	MGP_WSBEiJ_G0033069	protein coding gene	Chr8:93750142-93777737 (-)

Human Ortholog

CES1, carboxylesterase 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CES1, carboxylesterase 1
Synonyms

ACAT, CE-1, CEH, CES2, hCE-1, HMSE, HMSE1, PCE-1, REH, SES1, TGH
Links

HGNC:1863

NCBI Gene ID: 1066

neXtProt AC: NX_P23141

UniProt: P23141
Chr Location

16q12.2; chr16:55802851-55833337 (-) GRCh38

MGI Vertebrate Homology

Ces1a stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CES1
Gene Tree

Ces1a

Diseases

2 with human CES1 associations

				Human Disease	Mouse Models
				colorectal cancer IDs colorectal cancer DOID:9256 ICD10CM:C18.9 KEGG:05210 MESH:D015179 NCI:C2956 NCI:C4978 OMIM:114500 UMLS_CUI:C0009404 UMLS_CUI:C0346629
				gastrointestinal system cancer IDs gastrointestinal system cancer DOID:3119 DOID:4945 DOID:8377 ICD10CM:C26.9 ICD9CM:239.0 MESH:D004067 MESH:D005770 NCI:C3052 NCI:C4890 UMLS_CUI:C0012243 UMLS_CUI:C0017185 UMLS_CUI:C0685938

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

3
Targeted

3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

33 strains or lines available

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All GO Annotations

22
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

708
Tissues

2
cDNA Data

2
Literature Summary

1

Images

Tissue x Stage Matrix

Other Mouse Links

GEO

Expression Atlas

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All Sequences

34
RefSeq

8
UniProt

2
CCDS

CCDS22526.1

Ensembl

ENSMUSG00000071047 (Evidence)
NCBI Gene

244595

			Length	Strain/Species	Flank
genomic	244595	NCBI Gene Model \| MGI Sequence Detail	27979	C57BL/6J	± kb
transcript	NM_001013764	RefSeq \| MGI Sequence Detail	1980	C57BL/6
polypeptide	NP_001013786	RefSeq \| MGI Sequence Detail	563	C57BL/6

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UniProt

2 Sequences
EC

3.1.1.-
InterPro Domains

IPR029058 Alpha/Beta hydrolase fold

IPR002018 Carboxylesterase, type B

IPR019826 Carboxylesterase type B, active site

IPR019819 Carboxylesterase type B, conserved site

IPR050309 Type-B Carboxylesterase/Lipase

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All nucleic 2

cDNA 2

Microarray probesets 1

Summaries

All 20

Developmental Gene Expression 1

Gene Ontology 2

Phenotypes 6
Earliest

J:164863 Holmes RS, et al., Recommended nomenclature for five mammalian carboxylesterase gene families: human, mouse, and rat genes and proteins. Mamm Genome. 2010 Oct;21(9-10):427-41
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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