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Defb45 Gene Detail
Summary
  • Symbol
    Defb45
  • Name
    defensin beta 45
  • Synonyms
    OTTMUSG00000015859
  • Feature Type
    protein coding gene
  • IDs
    MGI:3650541
    NCBI Gene: 433490
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:152435111-152438405 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 75.41 cM
Strain
Comparison
more
  • SNPs within 2kb
    200 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3650541
 protein coding gene Chr2:152435111-152441319 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026670
 protein coding gene Chr2:157156492-157162696 (-)
A/J MGP_AJ_G0026636
 protein coding gene Chr2:150882593-150888777 (-)
AKR/J MGP_AKRJ_G0026606
 protein coding gene Chr2:155288389-155294596 (-)
BALB/cJ MGP_BALBcJ_G0026645
 protein coding gene Chr2:151192846-151199051 (-)
C3H/HeJ MGP_C3HHeJ_G0026388
 protein coding gene Chr2:155669775-155677111 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027094
 protein coding gene Chr2:161727366-161733574 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024465
 protein coding gene Chr2:144475939-144482473 (-)
CAST/EiJ MGP_CASTEiJ_G0025849
 protein coding gene Chr2:155914780-155920930 (-)
CBA/J MGP_CBAJ_G0026366
 protein coding gene Chr2:167658967-167665172 (-)
DBA/2J MGP_DBA2J_G0026502
 protein coding gene Chr2:150097066-150103313 (-)
FVB/NJ MGP_FVBNJ_G0026468
 protein coding gene Chr2:148551475-148557678 (-)
LP/J MGP_LPJ_G0026606
 protein coding gene Chr2:157306828-157313073 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026489
 protein coding gene Chr2:171767184-171773409 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027150
 protein coding gene Chr2:155173717-155179929 (-)
PWK/PhJ MGP_PWKPhJ_G0025583
 protein coding gene Chr2:149618547-149624879 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025386
 protein coding gene Chr2:154023150-154029382 (-)
WSB/EiJ MGP_WSBEiJ_G0025919
 protein coding gene Chr2:156088938-156095143 (-)



Homology
less
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotype references
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    1
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    2 involving Defb45
  • Find Mice (IMSR)
    6 strains or lines available
Gene Ontology
(GO)
Classifications
less
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

Cellular Component
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    6
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 433490 NCBI Gene Model | MGI Sequence Detail 3295 C57BL/6J ±  kb
transcript NM_001037752 RefSeq | MGI Sequence Detail 388 C57BL/6  
polypeptide NP_001032841 RefSeq | MGI Sequence Detail 66 C57BL/6  
For the selected sequence
Protein
Information
less
  • UniProt
    1 Sequence
  • InterPro Domains
    IPR025933 Beta-defensin
    IPR050544 Beta-defensin antimicrobial peptides
Molecular
Reagents
less
  • All nucleic 6
    cDNA 6

    Microarray probesets 2
References
more
  • Summaries
    All 23
    Phenotypes 7
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory