Garin3 MGI Mouse Gene Detail - MGI:3650836 - golgi associated RAB2 interactor 3

Symbol

Garin3
Name

golgi associated RAB2 interactor 3
Synonyms

Fam71b, OTTMUSG00000005491

Feature Type

protein coding gene
IDs

MGI:3650836
NCBI Gene: 432552
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr11:46295555-46298812 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 27.83 cM

SNPs within 2kb

141 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3650836	protein coding gene	Chr11:46287386-46298812 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018193	protein coding gene	Chr11:45315095-45328305 (+)
A/J	MGP_AJ_G0018165	protein coding gene	Chr11:43575678-43587067 (+)
AKR/J	MGP_AKRJ_G0018130	protein coding gene	Chr11:44830159-44844099 (+)
BALB/cJ	MGP_BALBcJ_G0018134	protein coding gene	Chr11:43734576-43745971 (+)
C3H/HeJ	MGP_C3HHeJ_G0017948	protein coding gene	Chr11:44870310-44882867 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018588	protein coding gene	Chr11:46659361-46670786 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016243	protein coding gene	Chr11:41553935-41565427 (+)
CAST/EiJ	MGP_CASTEiJ_G0017511	protein coding gene	Chr11:44995492-45007660 (+)
CBA/J	MGP_CBAJ_G0017920	protein coding gene	Chr11:48840972-48852921 (+)
DBA/2J	MGP_DBA2J_G0018030	protein coding gene	Chr11:43320846-43332242 (+)
FVB/NJ	MGP_FVBNJ_G0018024	protein coding gene	Chr11:42996423-43009459 (+)
LP/J	MGP_LPJ_G0018102	protein coding gene	Chr11:45561241-45574865 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018048	protein coding gene	Chr11:50366477-50379186 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018627	protein coding gene	Chr11:44989303-45002312 (+)
PWK/PhJ	MGP_PWKPhJ_G0017291	protein coding gene	Chr11:43407570-43419384 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017084	protein coding gene	Chr11:44804178-44817657 (+)
WSB/EiJ	MGP_WSBEiJ_G0017561	protein coding gene	Chr11:44689578-44700945 (+)

Human Ortholog

GARIN3, golgi associated RAB2 interactor family member 3

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GARIN3, golgi associated RAB2 interactor family member 3
Synonyms

FAM71B, GARI-L3
Links

HGNC:28397

NCBI Gene ID: 153745

neXtProt AC: NX_Q8TC56

UniProt: Q8TC56
Chr Location

5q33.3; chr5:157161846-157166264 (-) GRCh38

MGI Vertebrate Homology

Garin3 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: GARIN3
Gene Tree

Garin3

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Phenotype Summary

6 phenotypes from 1 allele in 1 genetic background
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

1
Endonuclease-mediated

4
Targeted

2
Genomic Mutations

1 involving Garin3
Find Mice (IMSR)

27 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null males are infertile, with impaired sperm motility, abnormal sperm head and acrosome morphology, and impaired sperm binding to and penetration of the zona pellucida.

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All GO Annotations

9
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas

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All Sequences

35
RefSeq

2
UniProt

3
CCDS

CCDS24576.1

Ensembl

ENSMUSG00000020401 (Evidence)
NCBI Gene

432552

			Length	Strain/Species	Flank
genomic	432552	NCBI Gene Model \| MGI Sequence Detail	3258	C57BL/6J	± kb
transcript	NM_001013783	RefSeq \| MGI Sequence Detail	2190	C57BL/6
polypeptide	Q5STT6	UniProt \| EBI \| MGI Sequence Detail	665	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000030864 Golgi-associated RAB2 interactor protein 3

(term hierarchy)
InterPro Domains

IPR022168 Golgi associated RAB2 interactor protein-like, Rab2B-binding domain
GlyGen

Q5STT6 1 site, 1 N-linked glycan (1 site)

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All nucleic 3

Genomic 1

cDNA 2

Microarray probesets 3

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MGI:6885577

Summaries

All 28

Gene Ontology 3

Phenotypes 10
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:350937 Wang H, et al., Golgi associated RAB2 interactor protein family contributes to murine male fertility to various extents by assuring correct morphogenesis of sperm heads. PLoS Genet. 2024 Jun;20(6):e1011337

TSS for Garin3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr101109	Chr11:46295547-46295557 (+)	-3 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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