Msmp MGI Mouse Gene Detail - MGI:3652339 - microseminoprotein, prostate associated

Symbol

Msmp
Name

microseminoprotein, prostate associated
Synonyms

OTTMUSG00000007017

Feature Type

protein coding gene
IDs

MGI:3652339
NCBI Gene: 100039672
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr4:43583216-43584494 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 23.05 cM

SNPs within 2kb

127 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3652339	protein coding gene	Chr4:43583216-43584494 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0028216	protein coding gene	Chr4:41709172-41710450 (-)
A/J	MGP_AJ_G0028172	protein coding gene	Chr4:40224918-40226196 (-)
AKR/J	MGP_AKRJ_G0028124	protein coding gene	Chr4:41137130-41138408 (-)
BALB/cJ	MGP_BALBcJ_G0028192	protein coding gene	Chr4:40315015-40316293 (-)
C3H/HeJ	MGP_C3HHeJ_G0027914	protein coding gene	Chr4:41767328-41768606 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0028633	protein coding gene	Chr4:43267215-43268493 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025945	protein coding gene	Chr4:37673443-37674718 (-)
CAST/EiJ	MGP_CASTEiJ_G0027354	protein coding gene	Chr4:41272388-41273666 (-)
CBA/J	MGP_CBAJ_G0027880	protein coding gene	Chr4:44586051-44587329 (-)
DBA/2J	MGP_DBA2J_G0028029	protein coding gene	Chr4:40134742-40136020 (-)
FVB/NJ	MGP_FVBNJ_G0027996	protein coding gene	Chr4:39357479-39358757 (-)
LP/J	MGP_LPJ_G0028128	protein coding gene	Chr4:41761730-41763008 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028020	protein coding gene	Chr4:47841838-47843116 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028669	protein coding gene	Chr4:41340912-41342190 (-)
PWK/PhJ	MGP_PWKPhJ_G0027080	protein coding gene	Chr4:40177383-40178661 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0026906	protein coding gene	Chr4:40901296-40902576 (-)
WSB/EiJ	MGP_WSBEiJ_G0027434	protein coding gene	Chr4:41239638-41240916 (-)

Human Ortholog

MSMP, microseminoprotein, prostate associated

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MSMP, microseminoprotein, prostate associated
Synonyms

PSMP
Links

HGNC:29663

NCBI Gene ID: 692094

neXtProt AC: NX_Q1L6U9

UniProt: Q1L6U9
Chr Location

9p13.3; chr9:35752990-35756613 (-) GRCh38

MGI Vertebrate Homology

Msmp stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: MSMP
Gene Tree

Msmp

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Phenotype Summary

8 phenotypes from 1 allele in 1 genetic background
2 phenotypes from multigenic genotypes
4 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Chemically and radiation induced

1
Endonuclease-mediated

2
Targeted

1
Genomic Mutations

1 involving Msmp
Find Mice (IMSR)

4 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit decreased susceptibility to injury induced liver damage and fibrosis.

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All GO Annotations

15
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

716
Tissues

5
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas

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All Sequences

25
RefSeq

2
UniProt

1
CCDS

CCDS51167.1

Ensembl

ENSMUSG00000078719 (Evidence)
NCBI Gene

100039672

			Length	Strain/Species	Flank
genomic	100039672	NCBI Gene Model \| MGI Sequence Detail	1279	C57BL/6J	± kb
transcript	NM_001099314	RefSeq \| MGI Sequence Detail	743	Not Specified
polypeptide	B1AWI6	UniProt \| EBI \| MGI Sequence Detail	139	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000010679 prostate-associated microseminoprotein

(term hierarchy)
InterPro Domains

IPR008735 Beta-microseminoprotein

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All nucleic 2

cDNA 1

Primer pair 1

Microarray probesets 1

Summaries

All 22

Developmental Gene Expression 1

Gene Ontology 6

Phenotypes 4
Earliest

J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
Latest

J:311042 She S, et al., PSMP/MSMP promotes hepatic fibrosis through CCR2 and represents a novel therapeutic target. J Hepatol. 2020 Mar;72(3):506-518

TSS for Msmp:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr41468	Chr4:43584386-43584393 (-)	104 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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