Cntnap5b Gene Detail

Summary

• Symbol
  Cntnap5b
• Name
  contactin associated protein-like 5B
• Synonyms
  C230078M14Rik, Caspr5-2

• Feature Type
  protein coding gene
• IDs
  MGI:3664583
  NCBI Gene: 241175
• Alliance
  gene page
• Transcription Start Sites
  6 TSS

Location &
Maps

• Sequence Map
  Chr1:99700490-100413667 bp, + strand

  From Ensembl annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 1, 48.19 cM
• Mapping Data
  2 experiments

Strain
Comparison

• SNPs within 2kb
  26696 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3664583	protein coding gene	Chr1:99700006-100418324 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016363	protein coding gene	Chr1:101607009-102391358 (+)
A/J	MGP_AJ_G0016347	protein coding gene	Chr1:98185391-98898823 (+)
AKR/J	MGP_AKRJ_G0016307	protein coding gene	Chr1:100860860-101623139 (+)
BALB/cJ	MGP_BALBcJ_G0016303	protein coding gene	Chr1:98203529-98908423 (+)
C3H/HeJ	MGP_C3HHeJ_G0016130	protein coding gene	Chr1:101208512-101948460 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016762	protein coding gene	Chr1:105605779-106365445 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014480	protein coding gene	Chr1:92364371-93044313 (+)
CAST/EiJ	MGP_CASTEiJ_G0015712	protein coding gene	Chr1:100256932-101011303 (+)
CBA/J	MGP_CBAJ_G0016103	protein coding gene	Chr1:109113241-109926834 (+)
DBA/2J	MGP_DBA2J_G0016208	protein coding gene	Chr1:97255527-97962446 (+)
FVB/NJ	MGP_FVBNJ_G0016209	protein coding gene	Chr1:96222522-96929890 (+)
LP/J	MGP_LPJ_G0016282	protein coding gene	Chr1:102917602-103669462 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016235	protein coding gene	Chr1:113016890-113853216 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016801	protein coding gene	Chr1:100936207-101668836 (+)
PWK/PhJ	MGP_PWKPhJ_G0015499	protein coding gene	Chr1:96403596-97115739 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015284	protein coding gene	Chr1:99729059-100463250 (+)
WSB/EiJ	MGP_WSBEiJ_G0015775	protein coding gene	Chr1:100722215-101490098 (+)

Homology

• Human Ortholog
  CNTNAP5, contactin associated protein family member 5

• Vertebrate Orthologs
  6

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  CNTNAP5, contactin associated protein family member 5
  
• Synonyms
  caspr5
• Links
  HGNC:18748

  NCBI Gene ID: 129684

  neXtProt AC: NX_Q8WYK1

  UniProt: Q8WYK1

  
  
• Chr Location
  2q14.3; chr2:124025287-124921219 (+)  GRCh38

---

• MGI Vertebrate Homology
  Cntnap5b stringent orthology
  1 human;1 mouse;2 rat;3 zebrafish
  
• HCOP
  vertebrate homology predictions: CNTNAP5
• Gene Tree
  Cntnap5b
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  1 phenotype from 1 allele in 1 genetic background
  11 phenotype references
  

• All Mutations and Alleles
  9
• Chemically induced (other)
  2
• Endonuclease-mediated
  3
• Radiation induced
  1
• Targeted
  3
• Genomic Mutations
  3 involving Cntnap5b
• Incidental Mutations
  Mutagenetix , APF
• Find Mice (IMSR)
  75 strains or lines available

Gene Ontology
(GO)
Classifications

• All GO Annotations
  3
• GO References
  3

Expression

• Assay Results
  776
• Tissues
  24
• cDNA Data
  6
• Literature Summary
  2

Tissue x Stage Matrix

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas

Sequences &
Gene Models

• All Sequences
  43
• RefSeq
  10
• UniProt
  3
• CCDS
  CCDS35682.1

• Ensembl
  ENSMUSG00000067028 (Evidence)
• NCBI Gene
  241175

Representative Sequences			Length	Strain/Species
genomic	ENSMUSG00000067028	Ensembl Gene Model | MGI Sequence Detail	713178	C57BL/6J
transcript	ENSMUST00000086738	Ensembl | MGI Sequence Detail	4027	Not Applicable
polypeptide	ENSMUSP00000083944	Ensembl | MGI Sequence Detail	1292	Not Applicable

Protein
Information

• UniProt
  3 Sequences
• Protein Ontology
  PR:000006196 contactin-associated protein like 5-2
  (term hierarchy)
• InterPro Domains
  IPR000421 Coagulation factor 5/8 C-terminal domain
  IPR013320 Concanavalin A-like lectin/glucanase domain superfamily
  IPR000742 EGF-like domain
  IPR002181 Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
  IPR036056 Fibrinogen-like, C-terminal
  IPR008979 Galactose-binding-like domain superfamily
  IPR001791 Laminin G domain
  IPR050372 Neurexin-related cell adhesion and synaptic protein
• GlyGen
  Q0V8T8 9 sites, 4 N-linked glycans (7 sites)

Molecular
Reagents

• All nucleic 10

  cDNA 6

  Primer pair 1

  Other 3

  
  

  Microarray probesets 1

Other
Accession IDs

MGI:3606070

References

• Summaries
  All 29

  Developmental Gene Expression 2

  Gene Ontology 3

  Phenotypes 11
• Earliest
  J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
• Latest
  J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Cntnap5b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr8239	Chr1:99700119-99700133 (+)	-364 bp
Tssr8240	Chr1:99700154-99700163 (+)	-331 bp
Tssr8241	Chr1:99717925-99717928 (+)	17,437 bp
Tssr8242	Chr1:99970508-99970509 (+)	270,019 bp
Tssr8243	Chr1:100180343-100180359 (+)	479,861 bp
Tssr8244	Chr1:100180373-100180383 (+)	479,888 bp