Cntnap5b MGI Mouse Gene Detail - MGI:3664583 - contactin associated protein-like 5B

Symbol

Cntnap5b
Name

contactin associated protein-like 5B
Synonyms

C230078M14Rik, Caspr5-2

Feature Type

protein coding gene
IDs

MGI:3664583
NCBI Gene: 241175
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr1:99700490-100413667 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 48.19 cM
Mapping Data

2 experiments

SNPs within 2kb

26696 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3664583	protein coding gene	Chr1:99700006-100418324 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016363	protein coding gene	Chr1:101607009-102391358 (+)
A/J	MGP_AJ_G0016347	protein coding gene	Chr1:98185391-98898823 (+)
AKR/J	MGP_AKRJ_G0016307	protein coding gene	Chr1:100860860-101623139 (+)
BALB/cJ	MGP_BALBcJ_G0016303	protein coding gene	Chr1:98203529-98908423 (+)
C3H/HeJ	MGP_C3HHeJ_G0016130	protein coding gene	Chr1:101208512-101948460 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016762	protein coding gene	Chr1:105605779-106365445 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014480	protein coding gene	Chr1:92364371-93044313 (+)
CAST/EiJ	MGP_CASTEiJ_G0015712	protein coding gene	Chr1:100256932-101011303 (+)
CBA/J	MGP_CBAJ_G0016103	protein coding gene	Chr1:109113241-109926834 (+)
DBA/2J	MGP_DBA2J_G0016208	protein coding gene	Chr1:97255527-97962446 (+)
FVB/NJ	MGP_FVBNJ_G0016209	protein coding gene	Chr1:96222522-96929890 (+)
LP/J	MGP_LPJ_G0016282	protein coding gene	Chr1:102917602-103669462 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016235	protein coding gene	Chr1:113016890-113853216 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016801	protein coding gene	Chr1:100936207-101668836 (+)
PWK/PhJ	MGP_PWKPhJ_G0015499	protein coding gene	Chr1:96403596-97115739 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015284	protein coding gene	Chr1:99729059-100463250 (+)
WSB/EiJ	MGP_WSBEiJ_G0015775	protein coding gene	Chr1:100722215-101490098 (+)

Human Ortholog

CNTNAP5, contactin associated protein family member 5

Vertebrate Orthologs

6

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CNTNAP5, contactin associated protein family member 5
Synonyms

caspr5
Links

HGNC:18748

NCBI Gene ID: 129684

neXtProt AC: NX_Q8WYK1

UniProt: Q8WYK1
Chr Location

2q14.3; chr2:124025287-124921219 (+) GRCh38

MGI Vertebrate Homology

Cntnap5b stringent orthology
1 human;1 mouse;2 rat;3 zebrafish
HCOP

vertebrate homology predictions: CNTNAP5
Gene Tree

Cntnap5b

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Chemically induced (other)

2
Endonuclease-mediated

3
Radiation induced

1
Targeted

3
Genomic Mutations

3 involving Cntnap5b
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

75 strains or lines available

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All GO Annotations

4
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

776
Tissues

24
cDNA Data

6
Literature Summary

2

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

43
RefSeq

10
UniProt

3
CCDS

CCDS35682.1

Ensembl

ENSMUSG00000067028 (Evidence)
NCBI Gene

241175

			Length	Strain/Species	Flank
genomic	ENSMUSG00000067028	Ensembl Gene Model \| MGI Sequence Detail	713178	C57BL/6J	± kb
transcript	ENSMUST00000086738	Ensembl \| MGI Sequence Detail	4027	Not Applicable
polypeptide	ENSMUSP00000083944	Ensembl \| MGI Sequence Detail	1292	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000006196 contactin-associated protein like 5-2

(term hierarchy)
InterPro Domains

IPR000421 Coagulation factor 5/8 C-terminal domain

IPR013320 Concanavalin A-like lectin/glucanase domain superfamily

IPR000742 EGF-like domain

IPR002181 Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain

IPR036056 Fibrinogen-like, C-terminal

IPR008979 Galactose-binding-like domain superfamily

IPR001791 Laminin G domain

IPR050372 Neurexin-related cell adhesion and synaptic protein
GlyGen

Q0V8T8 9 sites, 4 N-linked glycans (7 sites)

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All nucleic 10

cDNA 6

Primer pair 1

Other 3

Microarray probesets 1

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MGI:3606070

Summaries

All 29

Developmental Gene Expression 2

Gene Ontology 3

Phenotypes 11
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Cntnap5b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr8239	Chr1:99700119-99700133 (+)	-364 bp
Tssr8240	Chr1:99700154-99700163 (+)	-331 bp
Tssr8241	Chr1:99717925-99717928 (+)	17,437 bp
Tssr8242	Chr1:99970508-99970509 (+)	270,019 bp
Tssr8243	Chr1:100180343-100180359 (+)	479,861 bp
Tssr8244	Chr1:100180373-100180383 (+)	479,888 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24