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Try10 Gene Detail
Summary
  • Symbol
    Try10
  • Name
    trypsin 10
  • Synonyms
    trypsinogen 10
  • Feature Type
    protein coding gene
  • IDs
    MGI:3687012
    NCBI Gene: 436522
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:41331039-41334848 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 19.48 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    194 from dbSNP Build 142
  • Strain Annotations
    15
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3687012
 protein coding gene Chr6:41331039-41334878 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030624
 protein coding gene Chr6:39851158-39859967 (+)
A/J MGP_AJ_G0030599
 protein coding gene Chr6:38176304-38179196 (+)
AKR/J MGP_AKRJ_G0030526
 protein coding gene Chr6:39387372-39388753 (+)
BALB/cJ MGP_BALBcJ_G0030609
 protein coding gene Chr6:38328312-38332025 (+)
C3H/HeJ MGP_C3HHeJ_G0030324
 protein coding gene Chr6:39452147-39455764 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031062
 protein coding gene Chr6:40833425-40839159 (+)
CAROLI/EiJ no annotation
CAST/EiJ MGP_CASTEiJ_G0029724
 protein coding gene Chr6:39245588-39249824 (+)
CBA/J MGP_CBAJ_G0030298
 protein coding gene Chr6:42515859-42522663 (+)
DBA/2J MGP_DBA2J_G0030444
 protein coding gene Chr6:38011285-38012494 (+)
FVB/NJ MGP_FVBNJ_G0030396
 protein coding gene Chr6:37672213-37676258 (+)
LP/J no annotation
NOD/ShiLtJ MGP_NODShiLtJ_G0030434
 protein coding gene Chr6:44760687-44867186 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031091
 protein coding gene Chr6:39296907-39301409 (+)
PWK/PhJ no annotation
SPRET/EiJ MGP_SPRETEiJ_G0029273
 protein coding gene Chr6:38999136-39010915 (+)
WSB/EiJ MGP_WSBEiJ_G0029800
 protein coding gene Chr6:39230750-39240845 (+)



Homology
more
  • Human Ortholog
    PRSS1, serine protease 1
  • Vertebrate Orthologs
    6
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PRSS1, serine protease 1
  • Synonyms
    TRP1, TRY1, TRY4, TRYP1
  • Links
    NCBI Gene ID: 5644
    neXtProt AC: NX_P07477
    UniProt: P07477

  • Chr Location
    7q34; chr7:142749468-142753072 (+)  GRCh38
  • Human Ortholog
    PRSS2, serine protease 2
  • Synonyms
    TRY2, TRY8, TRYP2
  • Links
    NCBI Gene ID: 5645
    neXtProt AC: NX_P07478
    UniProt: P07478

  • Chr Location
    7q34; chr7:142760398-142774564 (+)  GRCh38
  • Human Ortholog
    PRSS3P2, PRSS3 pseudogene 2
  • Synonyms
    T6, TRY6
  • Links
    NCBI Gene ID: 154754
    UniProt: Q8NHM4

  • Chr Location
    7q34
Human Diseases
more
  • Diseases
    1 with human PRSS1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    3 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    7
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    48
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000071521 Ensembl Gene Model | MGI Sequence Detail 3810 C57BL/6J ±  kb
    transcript ENSMUST00000072103 Ensembl | MGI Sequence Detail 860 Not Applicable  
    polypeptide ENSMUSP00000071976 Ensembl | MGI Sequence Detail 246 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • EC
      3.4.21.4
    • InterPro Domains
      IPR001314 Peptidase S1A, chymotrypsin family
      IPR009003 Peptidase S1, PA clan
      IPR043504 Peptidase S1, PA clan, chymotrypsin-like fold
      IPR050127 Serine Proteases (Peptidase S1 Family)
      IPR001254 Serine proteases, trypsin domain
      IPR018114 Serine proteases, trypsin family, histidine active site
      IPR033116 Serine proteases, trypsin family, serine active site
    • GlyGen
      Q792Z1 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 48
      cDNA 48

      Microarray probesets 1
    References
    more
    • Summaries
      All 15
      Developmental Gene Expression 1
      Gene Ontology 2
      Phenotypes 3
    • Earliest
      J:356223 Martinez-Ramirez AS, et al., Specific Temporal Requirement of Prox1 Activity During Pancreatic Acinar Cell Development. Gastro Hep Adv. 2022;1(5):807-823
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory