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Aktip Gene Detail
Summary
  • Symbol
    Aktip
  • Name
    AKT interacting protein
  • Synonyms
    Ft1
  • Feature Type
    protein coding gene
  • IDs
    MGI:3693832
    NCBI Gene: 14339
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:91834267-91862122 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 44.25 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    905 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3693832
 protein coding gene Chr8:91834267-91926604 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033930
 protein coding gene Chr8:92333754-92355940 (-)
A/J MGP_AJ_G0033913
 protein coding gene Chr8:88702664-88725638 (-)
AKR/J MGP_AKRJ_G0033839
 protein coding gene Chr8:91211746-91233987 (-)
BALB/cJ MGP_BALBcJ_G0033905
 protein coding gene Chr8:88869177-88891504 (-)
C3H/HeJ MGP_C3HHeJ_G0033615
 protein coding gene Chr8:91910216-91932556 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034426
 protein coding gene Chr8:95757889-95780282 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031367
 protein coding gene Chr8:82645510-82667669 (-)
CAST/EiJ MGP_CASTEiJ_G0032947
 protein coding gene Chr8:91399042-91421246 (-)
CBA/J MGP_CBAJ_G0033591
 protein coding gene Chr8:98987314-99011764 (-)
DBA/2J MGP_DBA2J_G0033745
 protein coding gene Chr8:88271227-88294102 (-)
FVB/NJ MGP_FVBNJ_G0033692
 protein coding gene Chr8:87205387-87227716 (-)
LP/J MGP_LPJ_G0033837
 protein coding gene Chr8:92453054-92475241 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033734
 protein coding gene Chr8:101405573-101429255 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034444
 protein coding gene Chr8:91314300-91339449 (-)
PWK/PhJ MGP_PWKPhJ_G0032649
 protein coding gene Chr8:87580741-87603464 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032486
 protein coding gene Chr8:90182605-90205981 (-)
WSB/EiJ MGP_WSBEiJ_G0033059
 protein coding gene Chr8:91777336-91801548 (-)



Homology
more
  • Human Ortholog
    AKTIP, AKT interacting protein
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AKTIP, AKT interacting protein
  • Synonyms
    FT1, FTS
  • Links
    NCBI Gene ID: 64400
    neXtProt AC: NX_Q9H8T0
    UniProt: Q9H8T0

  • Chr Location
    16q12.2; chr16:53491040-53504412 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    28 phenotypes from 2 alleles in 2 genetic backgrounds
    11 phenotypes from multigenic genotypes
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a hypomorphic allele exhibit impaired growth, skeletal and skin defects, abnormal heart tissue, and sterility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    24
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    918
  • Tissues
    83
  • cDNA Data
    12
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14339 NCBI Gene Model | MGI Sequence Detail 27856 C57BL/6J ±  kb
    transcript NM_001302267 RefSeq | MGI Sequence Detail 2240 ZRU/MplStud  
    polypeptide Q64362 UniProt | EBI | MGI Sequence Detail 292 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 17
      Genomic 3
      cDNA 13
      Primer pair 1

      Microarray probesets 7
    References
    more
    • Summaries
      All 45
      Developmental Gene Expression 6
      Gene Ontology 6
      Phenotypes 11
    • Earliest
      J:20159 van der Hoeven F, et al., Programmed cell death is affected in the novel mouse mutant Fused toes (Ft). Development. 1994 Sep;120(9):2601-7
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory