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Zglp1 Gene Detail
Summary
  • Symbol
    Zglp1
  • Name
    zinc finger, GATA-like protein 1
  • Synonyms
    Glp1
  • Feature Type
    protein coding gene
  • IDs
    MGI:3696042
    NCBI Gene: 100009600
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr9:20973689-20978389 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 7.70 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    181 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3696042
 protein coding gene Chr9:20973689-20978389 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034438
 protein coding gene Chr9:18244723-18249394 (-)
A/J MGP_AJ_G0034416
 protein coding gene Chr9:17942585-17947285 (-)
AKR/J MGP_AKRJ_G0034343
 protein coding gene Chr9:18264205-18268905 (-)
BALB/cJ MGP_BALBcJ_G0034407
 protein coding gene Chr9:17835979-17840667 (-)
C3H/HeJ MGP_C3HHeJ_G0034119
 protein coding gene Chr9:18573779-18578479 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034928
 protein coding gene Chr9:18982094-18988200 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031858
 protein coding gene Chr9:17063397-17069504 (-)
CAST/EiJ MGP_CASTEiJ_G0033442
 protein coding gene Chr9:18400616-18406537 (-)
CBA/J MGP_CBAJ_G0034092
 protein coding gene Chr9:19687469-19692166 (-)
DBA/2J MGP_DBA2J_G0034251
 protein coding gene Chr9:17921730-17926430 (-)
FVB/NJ MGP_FVBNJ_G0034194
 protein coding gene Chr9:17431854-17437068 (-)
LP/J MGP_LPJ_G0034336
 protein coding gene Chr9:18417912-18422603 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034237
 protein coding gene Chr9:21308129-21313625 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034948
 protein coding gene Chr9:18211074-18215768 (-)
PWK/PhJ MGP_PWKPhJ_G0033148
 protein coding gene Chr9:17895221-17899969 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032982
 protein coding gene Chr9:18263797-18268495 (-)
WSB/EiJ MGP_WSBEiJ_G0033557
 protein coding gene Chr9:17950269-17956221 (-)



Homology
more
  • Human Ortholog
    ZGLP1, zinc finger GATA like protein 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ZGLP1, zinc finger GATA like protein 1
  • Synonyms
    GATAD3, GLP-1, GLP1
  • Links
    NCBI Gene ID: 100125288
    neXtProt AC: NX_P0C6A0
    UniProt: P0C6A0

  • Chr Location
    19p13.2; chr19:10304803-10309880 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mutations result in female and male infertility due to failure of germ cell development.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    738
  • Tissues
    16
  • cDNA Data
    2
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 100009600 NCBI Gene Model | MGI Sequence Detail 4701 C57BL/6J ±  kb
    transcript NM_001103168 RefSeq | MGI Sequence Detail 1010 C57BL/6  
    polypeptide Q1WG82 UniProt | EBI | MGI Sequence Detail 266 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 3
      cDNA 2
      Primer pair 1

      Microarray probesets 1
    References
    more
    • Summaries
      All 23
      Developmental Gene Expression 3
      Gene Ontology 4
      Phenotypes 7
    • Earliest
      J:116977 Li S, et al., GLP-1: a novel zinc finger protein required in somatic cells of the gonad for germ cell development. Dev Biol. 2007 Jan 1;301(1):106-16
    • Latest
      J:325585 Maiseyeu A, et al., Plaque-targeted, proteolysis-resistant, activatable and MRI-visible nano-GLP-1 receptor agonist targets smooth muscle cell differentiation in atherosclerosis. Theranostics. 2022;12(6):2741-2757
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory