Arhgap23 MGI Mouse Gene Detail - MGI:3697726 - Rho GTPase activating protein 23

Symbol

Arhgap23
Name

Rho GTPase activating protein 23

Feature Type

protein coding gene
IDs

MGI:3697726
NCBI Gene: 58996
Alliance

gene page
Transcription Start Sites

13 TSS

Sequence Map

Chr11:97306359-97393228 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 60.97 cM
Mapping Data

1 experiment

SNPs within 2kb

2088 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3697726	protein coding gene	Chr11:97295183-97393228 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019031	protein coding gene	Chr11:99840798-99936045 (+)
A/J	MGP_AJ_G0018999	protein coding gene	Chr11:95730389-95819493 (+)
AKR/J	MGP_AKRJ_G0018969	protein coding gene	Chr11:98708534-98799290 (+)
BALB/cJ	MGP_BALBcJ_G0018972	protein coding gene	Chr11:96214307-96307649 (+)
C3H/HeJ	MGP_C3HHeJ_G0018786	protein coding gene	Chr11:98824936-98913484 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019424	protein coding gene	Chr11:102937491-103032130 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017055	protein coding gene	Chr11:93191482-93279492 (+)
CAST/EiJ	MGP_CASTEiJ_G0018339	protein coding gene	Chr11:99682207-99775608 (+)
CBA/J	MGP_CBAJ_G0018757	protein coding gene	Chr11:107179283-107273973 (+)
DBA/2J	MGP_DBA2J_G0018865	protein coding gene	Chr11:95286924-95374311 (+)
FVB/NJ	MGP_FVBNJ_G0018854	protein coding gene	Chr11:94769871-94862857 (+)
LP/J	MGP_LPJ_G0018935	protein coding gene	Chr11:100353943-100445000 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018881	protein coding gene	Chr11:107044772-107136632 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019464	protein coding gene	Chr11:99002245-99095274 (+)
PWK/PhJ	MGP_PWKPhJ_G0018111	protein coding gene	Chr11:96266417-96359229 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017901	protein coding gene	Chr11:98713086-98803176 (+)
WSB/EiJ	MGP_WSBEiJ_G0018389	protein coding gene	Chr11:98904606-98999582 (+)

Human Ortholog

ARHGAP23, Rho GTPase activating protein 23

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ARHGAP23, Rho GTPase activating protein 23
Links

HGNC:29293

NCBI Gene ID: 57636

neXtProt AC: NX_Q9P227

UniProt: Q9P227
Chr Location

17q12; chr17:38419275-38512385 (+) GRCh38

MGI Vertebrate Homology

Arhgap23 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: ARHGAP23
Gene Tree

Arhgap23

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
20 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

117
Endonuclease-mediated

1
Gene trapped

111
Targeted

5
Genomic Mutations

1 involving Arhgap23
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

133 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

2
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

753
Tissues

31
cDNA Data

40
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase arhgap23

ZFIN arhgap23a

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All Sequences

81
RefSeq

30
UniProt

4
CCDS

CCDS36293.1

Ensembl

ENSMUSG00000049807 (Evidence)
NCBI Gene

58996

			Length	Strain/Species	Flank
genomic	ENSMUSG00000049807	Ensembl Gene Model \| MGI Sequence Detail	86870	C57BL/6J	± kb
transcript	ENSMUST00000121799	Ensembl \| MGI Sequence Detail	5816	Not Applicable
polypeptide	ENSMUSP00000112999	Ensembl \| MGI Sequence Detail	1488	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000004229 Rho GTPase-activating protein 23

(term hierarchy)
InterPro Domains

IPR001478 PDZ domain

IPR041489 PDZ domain 6

IPR036034 PDZ superfamily

IPR011993 PH-like domain superfamily

IPR001849 Pleckstrin homology domain

IPR041681 Pleckstrin homology domain 9

IPR000198 Rho GTPase-activating protein domain

IPR008936 Rho GTPase activation protein
GlyGen

Q69ZH9 3 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (1 site)

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All nucleic 42

cDNA 40

Primer pair 2

Microarray probesets 6

Summaries

All 37

Developmental Gene Expression 2

Gene Ontology 2

Phenotypes 20
Earliest

J:56548 Zheng B, et al., Engineering a mouse balancer chromosome. Nat Genet. 1999 Aug;22(4):375-8
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Arhgap23:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr104623	Chr11:97306353-97306364 (+)	0 bp
Tssr104624	Chr11:97306380-97306402 (+)	32 bp
Tssr104625	Chr11:97306403-97306423 (+)	54 bp
Tssr104626	Chr11:97326137-97326160 (+)	19,790 bp
Tssr104627	Chr11:97326162-97326173 (+)	19,809 bp
Tssr104628	Chr11:97326195-97326205 (+)	19,841 bp
Tssr3661	Chr11:97326215-97326221 (+)	19,859 bp
Tssr104629	Chr11:97327101-97327146 (+)	20,765 bp
Tssr104630	Chr11:97329011-97329014 (+)	22,654 bp
Tssr104631	Chr11:97330979-97331002 (+)	24,632 bp
Tssr104632	Chr11:97331005-97331031 (+)	24,659 bp
Tssr104633	Chr11:97331045-97331064 (+)	24,696 bp
Tssr104634	Chr11:97340962-97341006 (+)	34,625 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24