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Uqcc6 Gene Detail
Summary
  • Symbol
    Uqcc6
  • Name
    ubiquinol-cytochrome c reductase complex assembly factor 6
  • Synonyms
    1190007I07Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:3698433
    NCBI Gene: 544717
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:82455685-82459062 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 39.72 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    226 from dbSNP Build 142
  • Strain Annotations
    13
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3698433
 protein coding gene Chr10:82455685-82459062 (-)
129S1/SvImJ no annotation
A/J MGP_AJ_G0017556
 protein coding gene Chr10:80551974-80555342 (-)
AKR/J no annotation
BALB/cJ MGP_BALBcJ_G0017519
 protein coding gene Chr10:80796855-80806463 (-)
C3H/HeJ MGP_C3HHeJ_G0017341
 protein coding gene Chr10:82849249-82862645 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017976
 protein coding gene Chr10:86261651-86283242 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015661
 protein coding gene Chr10:76303976-76307301 (-)
CAST/EiJ MGP_CASTEiJ_G0016942
 protein coding gene Chr10:87035131-87039238 (+)
CBA/J MGP_CBAJ_G0017311
 protein coding gene Chr10:89830455-89839691 (-)
DBA/2J MGP_DBA2J_G0017417
 protein coding gene Chr10:79719705-79730836 (-)
FVB/NJ no annotation
LP/J no annotation
NOD/ShiLtJ MGP_NODShiLtJ_G0017474
 protein coding gene Chr10:95970811-95973900 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018013
 protein coding gene Chr10:82711600-82716073 (-)
PWK/PhJ MGP_PWKPhJ_G0016723
 protein coding gene Chr10:83867710-83879137 (+)
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0017001
 protein coding gene Chr10:86951471-86954887 (+)



Homology
more
  • Human Ortholog
    UQCC6, ubiquinol-cytochrome c reductase complex assembly factor 6
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    UQCC6, ubiquinol-cytochrome c reductase complex assembly factor 6
  • Synonyms
    BR, BRAWNIN, C12orf73
  • Links
    NCBI Gene ID: 728568
    neXtProt AC: NX_Q69YU5
    UniProt: Q69YU5

  • Chr Location
    12q23.3; chr12:103940763-103965708 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit depletion of complex II in the mitochondria with a mild increase in circulating lactate level and reduced exercise tolerance.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    710
  • Tissues
    1
  • cDNA Data
    38
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 544717 NCBI Gene Model | MGI Sequence Detail 3378 C57BL/6J ±  kb
    transcript NM_001135567 RefSeq | MGI Sequence Detail 748 C57BL/6  
    polypeptide Q8BTC1 UniProt | EBI | MGI Sequence Detail 67 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 40
      cDNA 38
      Primer pair 2

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:7380601
    References
    more
    • Summaries
      All 31
      Developmental Gene Expression 1
      Gene Ontology 5
      Phenotypes 10
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:346439 Lanfranchi M, et al., The AMPK-related kinase NUAK1 controls cortical axons branching by locally modulating mitochondrial metabolic functions. Nat Commun. 2024 Mar 21;15(1):2487
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory