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Mterf1b Gene Detail
Summary
  • Symbol
    Mterf1b
  • Name
    mitochondrial transcription termination factor 1b
  • Synonyms
    Gm9897
  • Feature Type
    protein coding gene
  • IDs
    MGI:3704243
    NCBI Gene: 208595
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr5:4242367-4247651 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 2.34 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    207 from dbSNP Build 142
  • Strain Annotations
    13
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3704243
 protein coding gene Chr5:4242329-4247652 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029268
 protein coding gene Chr5:1026541-1041980 (+)
A/J no annotation
AKR/J MGP_AKRJ_G0029179
 protein coding gene Chr5:597554-600898 (-)
BALB/cJ no annotation
C3H/HeJ no annotation
C57BL/6NJ MGP_C57BL6NJ_G0029699
 protein coding gene Chr5:1321207-1326491 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026941
 protein coding gene Chr5:922393-923294 (+)
CAST/EiJ no annotation
CBA/J no annotation
DBA/2J MGP_DBA2J_G0029080
 protein coding gene Chr5:758166-761394 (-)
FVB/NJ MGP_FVBNJ_G0029044
 protein coding gene Chr5:978877-980261 (+)
LP/J MGP_LPJ_G0029170
 protein coding gene Chr5:778663-780047 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029071
 protein coding gene Chr5:1120380-1125659 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029728
 protein coding gene Chr5:724358-734452 (-)
PWK/PhJ MGP_PWKPhJ_G0028103
 protein coding gene Chr5:1056803-1058147 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027936
 protein coding gene Chr5:1527944-1529300 (-)
WSB/EiJ MGP_WSBEiJ_G0028460
 protein coding gene Chr5:750246-751640 (-)



Homology
more
  • Human Ortholog
    MTERF1, mitochondrial transcription termination factor 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MTERF1, mitochondrial transcription termination factor 1
  • Synonyms
    MTERF
  • Links
    NCBI Gene ID: 7978
    neXtProt AC: NX_Q99551
    UniProt: Q99551

  • Chr Location
    7q21.2; chr7:91692008-91880702 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from multigenic genotypes
    2 phenotype references
Mice homozygous for a knock-out allele of both Mterf1a and Mterf1b exhibit impaired transcription initiation at light-strand promoters resulting in a decrease of de novo transcription and reduced 7S RNA.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    5
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000053178 Ensembl Gene Model | MGI Sequence Detail 5285 C57BL/6J ±  kb
transcript ENSMUST00000177258 Ensembl | MGI Sequence Detail 1368 Not Applicable  
polypeptide ENSMUSP00000135408 Ensembl | MGI Sequence Detail 381 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000010715 transcription termination factor 1, mitochondrial
    (term hierarchy)
  • InterPro Domains
    IPR038538 MTERF superfamily, mitochondrial/chloroplastic
    IPR003690 Transcription termination factor, mitochondrial/chloroplastic
Molecular
Reagents
less
  • All nucleic 6
    cDNA 6

    Microarray probesets 2
References
more
  • Summaries
    All 20
    Gene Ontology 6
    Phenotypes 2
  • Earliest
    J:94621 Li X, et al., Cloning and characterization of mouse mTERF encoding a mitochondrial transcriptional termination factor. Biochem Biophys Res Commun. 2005 Jan 14;326(2):505-10
  • Latest
    J:198969 Terzioglu M, et al., MTERF1 binds mtDNA to prevent transcriptional interference at the light-strand promoter but is dispensable for rRNA gene transcription regulation. Cell Metab. 2013 Apr 2;17(4):618-26
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory