Hotairm1 Gene Detail

Summary

• Symbol
  Hotairm1
• Name
  Hoxa transcript antisense RNA, myeloid-specific 1
• Synonyms
  Gm15051, Hoxaas1

• Feature Type
  antisense lncRNA gene
  BioType Conflict
  
• IDs
  MGI:3705155
  NCBI Gene: 105242658
• Alliance
  gene page

Location &
Maps

• Sequence Map
  Chr6:52135504-52139000 bp, + strand

  From NCBI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 6, 25.40 cM

Strain
Comparison

• SNPs within 2kb
  71 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3705155	antisense lncRNA gene	Chr6:52133882-52139099 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0004269	antisense lncRNA gene	Chr6:51390001-51397537 (+)
A/J	MGP_AJ_G0004247	antisense lncRNA gene	Chr6:48992414-48997639 (+)
AKR/J	MGP_AKRJ_G0004228	antisense lncRNA gene	Chr6:50696293-50703100 (+)
BALB/cJ	MGP_BALBcJ_G0004234	antisense lncRNA gene	Chr6:49351746-49356988 (+)
C3H/HeJ	MGP_C3HHeJ_G0004182	antisense lncRNA gene	Chr6:50706583-50711822 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0004383	antisense lncRNA gene	Chr6:52529877-52535099 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0003856	antisense lncRNA gene	Chr6:46640457-46645740 (+)
CAST/EiJ	MGP_CASTEiJ_G0004144	antisense lncRNA gene	Chr6:50518623-50523899 (+)
CBA/J	MGP_CBAJ_G0004176	antisense lncRNA gene	Chr6:54725644-54730852 (+)
DBA/2J	MGP_DBA2J_G0004192	antisense lncRNA gene	Chr6:48915397-48920605 (+)
FVB/NJ	MGP_FVBNJ_G0004208	antisense lncRNA gene	Chr6:48525150-48530665 (+)
LP/J	MGP_LPJ_G0004270	antisense lncRNA gene	Chr6:51371222-51382307 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0004198	antisense lncRNA gene	Chr6:57360828-57366852 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0004380	antisense lncRNA gene	Chr6:50622402-50627627 (+)
PWK/PhJ	MGP_PWKPhJ_G0004097	antisense lncRNA gene	Chr6:48536961-48542348 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0004041	antisense lncRNA gene	Chr6:49960273-49965548 (+)
WSB/EiJ	MGP_WSBEiJ_G0004180	antisense lncRNA gene	Chr6:50638709-50643938 (+)

Homology

• Human Ortholog
  HOTAIRM1, HOXA transcript antisense RNA, myeloid-specific 1

• Vertebrate Orthologs
  1

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  HOTAIRM1, HOXA transcript antisense RNA, myeloid-specific 1
  
• Synonyms
  HOXA1-AS1, HOXA-AS1, NCRNA00179
• Links
  HGNC:37117

  NCBI Gene ID: 100506311

  
  
• Chr Location
  chr7:27095647-27100265 (+)  GRCh38

---

• MGI Vertebrate Homology
  Hotairm1 stringent orthology
  1 human;1 mouse
  
• HCOP
  vertebrate homology predictions: HOTAIRM1
• Gene Tree
  Hotairm1
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  12 phenotype references
  

• All Mutations and Alleles
  20
• Gene trapped
  19
• Targeted
  1
• Genomic Mutations
  1 involving Hotairm1
• Find Mice (IMSR)
  5 strains or lines available

Gene Ontology
(GO)
Classifications

Expression

• Assay Results
  706

Tissue x Stage Matrix

• Other Mouse Links
  GEO
  Expression Atlas

Sequences &
Gene Models

• All Sequences
  28
• RefSeq
  1

• Ensembl
  ENSMUSG00000087658 (Evidence)
• NCBI Gene
  105242658

Representative Sequences			Length	Strain/Species
genomic	105242658	NCBI Gene Model | MGI Sequence Detail	3497	C57BL/6J
transcript	NR_131181	RefSeq | MGI Sequence Detail	253	ZRU/MplStud

References

• Summaries
  All 19

  Phenotypes 12
• Earliest
  J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
• Latest
  J:322498 Chen W, et al., Long Noncoding RNA HOTAIRM1 Promotes Immunosuppression in Sepsis by Inducing T Cell Exhaustion. J Immunol. 2022 Feb 1;208(3):618-632