Mroh2a Gene Detail

Summary

• Symbol
  Mroh2a
• Name
  maestro heat-like repeat family member 2A
• Synonyms
  ENSMUSG00000044873, Heatr7b1, OTTMUSG00000020804

• Feature Type
  protein coding gene
• IDs
  MGI:3705228
  NCBI Gene: 100040766
• Alliance
  gene page
• Transcription Start Sites
  10 TSS

Location &
Maps

• Sequence Map
  Chr1:88154713-88190011 bp, + strand

  From NCBI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 1, 44.55 cM
• Mapping Data
  1 experiment

Strain
Comparison

• SNPs within 2kb
  1150 from dbSNP Build 142
• Strain Annotations
  9

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3705228	protein coding gene	Chr1:88154708-88190011 (+)
129S1/SvImJ	no annotation
A/J	no annotation
AKR/J	no annotation
BALB/cJ	no annotation
C3H/HeJ	MGP_C3HHeJ_G0016049	protein coding gene	Chr1:89197826-89206578 (+)
C57BL/6NJ	no annotation
CAROLI/EiJ	MGP_CAROLIEiJ_G0014397	protein coding gene	Chr1:80715984-80748970 (+)
CAST/EiJ	MGP_CASTEiJ_G0015635	protein coding gene	Chr1:88443875-88454944 (+)
CBA/J	no annotation
DBA/2J	no annotation
FVB/NJ	no annotation
LP/J	no annotation
NOD/ShiLtJ	MGP_NODShiLtJ_G0016152	protein coding gene	Chr1:99460140-99461830 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016719	protein coding gene	Chr1:88963163-89017760 (+)
PWK/PhJ	MGP_PWKPhJ_G0015419	protein coding gene	Chr1:85016943-85023985 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015201	protein coding gene	Chr1:87884141-87920351 (+)
WSB/EiJ	MGP_WSBEiJ_G0015692	protein coding gene	Chr1:88644929-88656411 (+)

Homology

• Human Ortholog
  MROH2A, maestro heat like repeat family member 2A

• Vertebrate Orthologs
  2

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  MROH2A, maestro heat like repeat family member 2A
  
• Synonyms
  HEATR7B1
• Links
  HGNC:27936

  NCBI Gene ID: 339766

  UniProt: A6NES4

  
  
• Chr Location
  2q37.1; chr2:233775679-233833423 (+)  GRCh38

---

• MGI Vertebrate Homology
  Mroh2a stringent orthology
  1 human;1 mouse;1 rat
  
• HCOP
  vertebrate homology predictions: MROH2A
• Gene Tree
  Mroh2a
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  6 phenotype references
  

• All Mutations and Alleles
  5
• Chemically induced (other)
  1
• Endonuclease-mediated
  1
• Radiation induced
  1
• Targeted
  2
• Genomic Mutations
  2 involving Mroh2a
• Incidental Mutations
  APF
• Find Mice (IMSR)
  109 strains or lines available

Gene Ontology
(GO)
Classifications

• All GO Annotations
  1
• GO References
  1

Expression

• Assay Results
  706
• cDNA Data
  4

Tissue x Stage Matrix

• Other Mouse Links
  GEO
  Expression Atlas

Sequences &
Gene Models

• All Sequences
  47
• RefSeq
  22
• UniProt
  3
• CCDS
  CCDS69921.1

• Ensembl
  ENSMUSG00000079429 (Evidence)
• NCBI Gene
  100040766

Representative Sequences			Length	Strain/Species
genomic	100040766	NCBI Gene Model | MGI Sequence Detail	35299	C57BL/6J
transcript	NM_001281466	RefSeq | MGI Sequence Detail	7502	C57BL/6
polypeptide	NP_001268395	RefSeq | MGI Sequence Detail	1671	C57BL/6

Protein
Information

• UniProt
  3 Sequences
• Protein Ontology
  PR:000036936 maestro heat-like repeat-containing protein family member 2A
  (term hierarchy)
• InterPro Domains
  IPR011989 Armadillo-like helical
  IPR016024 Armadillo-type fold
  IPR045206 Maestro heat-like repeat-containing protein
  IPR048465 Maestro, HEAT repeats

Molecular
Reagents

• All nucleic 4

  cDNA 4

  
  

  Microarray probesets 3

Other
Accession IDs

MGI:3704192

References

• Summaries
  All 24

  Gene Ontology 1

  Phenotypes 6
• Earliest
  J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
• Latest
  J:267911 Timmermans S, et al., Overview of inactivating mutations in the protein-coding genome of the mouse reference strain C57BL/6J. JCI Insight. 2018 Jul 12;3(13)

TSS for Mroh2a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr7956	Chr1:88154727-88154786 (+)	44 bp
Tssr7957	Chr1:88154792-88154793 (+)	80 bp
Tssr7958	Chr1:88186832-88186847 (+)	32,127 bp
Tssr7959	Chr1:88186854-88186867 (+)	32,148 bp
Tssr7960	Chr1:88186869-88186890 (+)	32,167 bp
Tssr7961	Chr1:88186916-88186919 (+)	32,205 bp
Tssr7962	Chr1:88187070-88187079 (+)	32,362 bp
Tssr7963	Chr1:88187098-88187109 (+)	32,391 bp
Tssr7964	Chr1:88187113-88187136 (+)	32,412 bp
Tssr7965	Chr1:88187149-88187160 (+)	32,442 bp