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Tomt Gene Detail
Summary
  • Symbol
    Tomt
  • Name
    transmembrane O-methyltransferase
  • Synonyms
    Comt2, F930017I19Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:3769724
    NCBI Gene: 791260
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:101549010-101555572 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 54.68 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    170 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3769724
 protein coding gene Chr7:101547577-101555572 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032592
 protein coding gene Chr7:104914252-104922238 (-)
A/J MGP_AJ_G0032568
 protein coding gene Chr7:102241150-102249136 (-)
AKR/J MGP_AKRJ_G0032504
 protein coding gene Chr7:104688526-104696512 (-)
BALB/cJ MGP_BALBcJ_G0032579
 protein coding gene Chr7:101940707-101948693 (-)
C3H/HeJ MGP_C3HHeJ_G0032293
 protein coding gene Chr7:105062488-105070483 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033076
 protein coding gene Chr7:108866521-108874507 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030070
 protein coding gene Chr7:104605068-104613277 (-)
CAST/EiJ MGP_CASTEiJ_G0031619
 protein coding gene Chr7:96618912-96626906 (-)
CBA/J MGP_CBAJ_G0032259
 protein coding gene Chr7:112636255-112644250 (-)
DBA/2J MGP_DBA2J_G0032411
 protein coding gene Chr7:100572647-100580620 (-)
FVB/NJ MGP_FVBNJ_G0032367
 protein coding gene Chr7:100351429-100360182 (-)
LP/J MGP_LPJ_G0032500
 protein coding gene Chr7:106231294-106239280 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032401
 protein coding gene Chr7:113965294-113973395 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033098
 protein coding gene Chr7:103959140-103967127 (-)
PWK/PhJ MGP_PWKPhJ_G0031337
 protein coding gene Chr7:93684545-93692849 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031181
 protein coding gene Chr7:91255468-91265569 (-)
WSB/EiJ MGP_WSBEiJ_G0031736
 protein coding gene Chr7:104646232-104654218 (-)



Homology
more
  • Human Ortholog
    LRRC51, leucine rich repeat containing 51
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LRRC51, leucine rich repeat containing 51
  • Links
    NCBI Gene ID: 120356739
    neXtProt AC: NX_Q96E66

  • Chr Location
    chr11:72080337-72096895 (+)  GRCh38
  • Human Ortholog
    LRTOMT, leucine rich transmembrane and O-methyltransferase domain containing
  • Synonyms
    CFAP111, DFNB63, LRRC51, LRRC51-TOMT, TOMT
  • Links
    NCBI Gene ID: 220074
    neXtProt AC: NX_Q8WZ04, NX_Q96E66

  • Chr Location
    11q13.4; chr11:72080331-72110782 (+)  GRCh38
  • Human Ortholog
    TOMT, transmembrane O-methyltransferase
  • Synonyms
    COMT2
  • Links
    NCBI Gene ID: 120356740

  • Chr Location
    chr11:72105924-72109596 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Tomt mouse models; 1 with human LRTOMT associations

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    27 phenotypes from 2 alleles in 3 genetic backgrounds
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a mutation of this gene exhibit marked hyperactivity, bidirectional circling and head-tossing. These behaviors are suppressed during sleep and nursing. Homozygous mutant males exhibit heightened male:male aggression.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 791260 NCBI Gene Model | MGI Sequence Detail 6563 C57BL/6J ±  kb
    transcript NM_001282088 RefSeq | MGI Sequence Detail 1358 C57BL/6  
    polypeptide A1Y9I9 UniProt | EBI | MGI Sequence Detail 258 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 1
      cDNA 1
    Other
    Accession IDs
    less
    MGI:3707696
    References
    more
    • Summaries
      All 32
      Diseases 1
      Gene Ontology 5
      Phenotypes 19
    • Earliest
      J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
    • Latest
      J:257320 Erickson T, et al., Integration of Tmc1/2 into the mechanotransduction complex in zebrafish hair cells is regulated by Transmembrane O-methyltransferase (Tomt). Elife. 2017 May 23;6:e28474
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    12/10/2024
    MGI 6.24     		The Jackson Laboratory