Xaf1 MGI Mouse Gene Detail - MGI:3772572 - XIAP associated factor 1

Symbol

Xaf1
Name

XIAP associated factor 1

Feature Type

protein coding gene
IDs

MGI:3772572
NCBI Gene: 327959
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr11:72192455-72204559 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 43.99 cM
Mapping Data

1 experiment

SNPs within 2kb

431 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3772572	protein coding gene	Chr11:72192229-72204560 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018635	protein coding gene	Chr11:72920353-72932522 (+)
A/J	MGP_AJ_G0018603	protein coding gene	Chr11:70193263-70208880 (+)
AKR/J	MGP_AKRJ_G0018572	protein coding gene	Chr11:72338239-72350340 (+)
BALB/cJ	MGP_BALBcJ_G0018575	protein coding gene	Chr11:70489228-70503695 (+)
C3H/HeJ	MGP_C3HHeJ_G0018388	protein coding gene	Chr11:72289105-72302247 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019026	protein coding gene	Chr11:75129864-75144225 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016669	protein coding gene	Chr11:67033025-67044833 (+)
CAST/EiJ	MGP_CASTEiJ_G0017943	protein coding gene	Chr11:72663960-72677319 (+)
CBA/J	MGP_CBAJ_G0018360	protein coding gene	Chr11:78454943-78466978 (+)
DBA/2J	MGP_DBA2J_G0018469	protein coding gene	Chr11:69834190-69845989 (+)
FVB/NJ	MGP_FVBNJ_G0018460	protein coding gene	Chr11:69366476-69378508 (+)
LP/J	MGP_LPJ_G0018540	protein coding gene	Chr11:73426144-73439127 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018483	protein coding gene	Chr11:79021335-79035179 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019068	protein coding gene	Chr11:72536447-72548546 (+)
PWK/PhJ	MGP_PWKPhJ_G0017716	protein coding gene	Chr11:70450344-70462163 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017506	protein coding gene	Chr11:72233489-72245716 (+)
WSB/EiJ	MGP_WSBEiJ_G0017997	protein coding gene	Chr11:72270023-72283080 (+)

Human Ortholog

XAF1, XIAP associated factor 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

XAF1, XIAP associated factor 1
Synonyms

BIRC4BP, HSXIAPAF1, XIAPAF1
Links

HGNC:30932

NCBI Gene ID: 54739

neXtProt AC: NX_Q6GPH4

UniProt: Q6GPH4
Chr Location

17p13.1; chr17:6755447-6775647 (+) GRCh38

MGI Vertebrate Homology

Xaf1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: XAF1
Gene Tree

Xaf1

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Phenotype Summary

11 phenotypes from 2 alleles in 2 genetic backgrounds
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (other)

1
Endonuclease-mediated

5
Gene trapped

1
Targeted

1
Genomic Mutations

2 involving Xaf1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

18 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null mutation display resistance to diet induced obesity, improved glucose tolerance and insulin sensitivity, and decreased heat generation.

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All GO Annotations

11
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

713
Tissues

1
cDNA Data

15
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

65
RefSeq

18
UniProt

6
CCDS

CCDS24984.2, CCDS70236.1

Ensembl

ENSMUSG00000040483 (Evidence)
NCBI Gene

327959

			Length	Strain/Species	Flank
genomic	ENSMUSG00000040483	Ensembl Gene Model \| MGI Sequence Detail	12105	C57BL/6J	± kb
transcript	ENSMUST00000146233	Ensembl \| MGI Sequence Detail	2597	Not Applicable
polypeptide	ENSMUSP00000123011	Ensembl \| MGI Sequence Detail	273	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000017471 XIAP-associated factor 1

(term hierarchy)
InterPro Domains

IPR051986 Innate Immunity and Apoptosis Regulator

IPR049439 TRAFD1/XAF1, zinc finger

IPR041386 XIAP-associated factor 1, C-terminal

IPR031220 XIAP-associated factor 1, C-terminal superfamily

IPR013083 Zinc finger, RING/FYVE/PHD-type

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All nucleic 16

cDNA 15

Primer pair 1

Microarray probesets 2

Summaries

All 42

Developmental Gene Expression 1

Gene Ontology 5

Phenotypes 16
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Xaf1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr102832	Chr11:72192439-72192497 (+)	13 bp
Tssr102833	Chr11:72196285-72196300 (+)	3,838 bp
Tssr102834	Chr11:72196327-72196343 (+)	3,880 bp
Tssr102835	Chr11:72197386-72197401 (+)	4,939 bp
Tssr102836	Chr11:72199434-72199455 (+)	6,990 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24