Aadacl2fm2 Gene Detail

Summary

• Symbol
  Aadacl2fm2
• Name
  AADACL2 family member 2
• Synonyms
  Gm5538

• Feature Type
  protein coding gene
• IDs
  MGI:3779495
  NCBI Gene: 433597
• Alliance
  gene page
• Transcription Start Sites
  1 TSS

Location &
Maps

• Sequence Map
  Chr3:59637211-59659754 bp, + strand

  From Ensembl annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 3, 29.07 cM
• Mapping Data
  1 experiment

Strain
Comparison

• SNPs within 2kb
  584 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3779495	protein coding gene	Chr3:59637207-59659818 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0027248	protein coding gene	Chr3:58578762-58602283 (+)
A/J	MGP_AJ_G0027208	protein coding gene	Chr3:56792486-56823584 (+)
AKR/J	MGP_AKRJ_G0027178	protein coding gene	Chr3:57972009-58001176 (+)
BALB/cJ	MGP_BALBcJ_G0027221	protein coding gene	Chr3:56592957-56617733 (+)
C3H/HeJ	MGP_C3HHeJ_G0026964	protein coding gene	Chr3:58189089-58212903 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027667	protein coding gene	Chr3:60757337-60785340 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025021	protein coding gene	Chr3:53065283-53085330 (+)
CAST/EiJ	MGP_CASTEiJ_G0026416	protein coding gene	Chr3:58371890-58393292 (+)
CBA/J	MGP_CBAJ_G0026940	protein coding gene	Chr3:62766343-62797877 (+)
DBA/2J	MGP_DBA2J_G0027074	protein coding gene	Chr3:56292127-56316982 (+)
FVB/NJ	MGP_FVBNJ_G0027042	protein coding gene	Chr3:55221533-55242898 (+)
LP/J	MGP_LPJ_G0027186	protein coding gene	Chr3:59392440-59413213 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027060	protein coding gene	Chr3:66918541-66950308 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027725	protein coding gene	Chr3:57917344-57941177 (+)
PWK/PhJ	MGP_PWKPhJ_G0026148	protein coding gene	Chr3:55951448-55975328 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025961	protein coding gene	Chr3:57521997-57545977 (+)
WSB/EiJ	MGP_WSBEiJ_G0026490	protein coding gene	Chr3:58002241-58025944 (+)

Homology

• MGI Vertebrate Homology
  Aadacl2fm2 stringent orthology
  1 mouse;1 rat;1 zebrafish
  
• Protein SuperFamily
  Arylacetamide_deacetylase
• Gene Tree
  Aadacl2fm2
  

Human Diseases

• References
  1 with disease annotations

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  5 phenotype references
  

• All Mutations and Alleles
  4
• Endonuclease-mediated
  1
• Gene trapped
  1
• Radiation induced
  1
• Targeted
  1
• Genomic Mutations
  1 involving Aadacl2fm2
• Incidental Mutations
  Mutagenetix , APF
• Find Mice (IMSR)
  27 strains or lines available

Gene Ontology
(GO)
Classifications

Expression

• Assay Results
  706

Tissue x Stage Matrix

• Other Mouse Links
  GEO
  Expression Atlas

Sequences &
Gene Models

• All Sequences
  25
• RefSeq
  2
• UniProt
  1
• CCDS
  CCDS50916.1

• Ensembl
  ENSMUSG00000090527 (Evidence)
• NCBI Gene
  433597

Representative Sequences			Length	Strain/Species
genomic	ENSMUSG00000090527	Ensembl Gene Model | MGI Sequence Detail	22544	C57BL/6J
transcript	ENSMUST00000168156	Ensembl | MGI Sequence Detail	1235	Not Applicable
polypeptide	ENSMUSP00000128877	Ensembl | MGI Sequence Detail	401	Not Applicable

Protein
Information

• UniProt
  1 Sequence
• EC
  3.1.1.71
• InterPro Domains
  IPR029058 Alpha/Beta hydrolase fold
  IPR013094 Alpha/beta hydrolase fold-3
  IPR017157 Arylacetamide deacetylase
  IPR050300 'GDXG' lipolytic enzyme
  IPR033140 Lipase, GDXG, putative serine active site

Other
Accession IDs

MGI:6330752

References

• Summaries
  All 12

  Diseases 1

  Phenotypes 5
• Earliest
  J:70677 Cook SA, et al., Mouse paracentric inversion In(3)55Rk mutates the urate oxidase gene. Cytogenet Cell Genet. 2001;93(1-2):77-82
• Latest
  J:302829 Lu J, et al., Mouse models for human hyperuricaemia: a critical review. Nat Rev Rheumatol. 2019 Jul;15(7):413-426

TSS for Aadacl2fm2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr29238	Chr3:59637203-59637211 (+)	-4 bp