About   Help   FAQ
Mthfsl Gene Detail
Summary
  • Symbol
    Mthfsl
  • Name
    5, 10-methenyltetrahydrofolate synthetase-like
  • Synonyms
    Gm2382
  • Feature Type
    protein coding gene
  • IDs
    MGI:3780550
    NCBI Gene: 100039707
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:88570655-88602349 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 47.24 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    550 from dbSNP Build 142
  • Strain Annotations
    7
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3780550
 protein coding gene Chr9:88567696-88602381 (-)
129S1/SvImJ no annotation
A/J no annotation
AKR/J no annotation
BALB/cJ no annotation
C3H/HeJ no annotation
C57BL/6NJ no annotation
CAROLI/EiJ MGP_CAROLIEiJ_G0032511
 protein coding gene Chr9:85211122-85236961 (+)
CAST/EiJ no annotation
CBA/J no annotation
DBA/2J MGP_DBA2J_G0034924
 protein coding gene Chr9:85978289-86017316 (-)
FVB/NJ no annotation
LP/J MGP_LPJ_G0035007
 protein coding gene Chr9:89846640-89874924 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034915
 protein coding gene Chr9:97478190-97482454 (+)
NZO/HlLtJ no annotation
PWK/PhJ MGP_PWKPhJ_G0033815
 protein coding gene Chr9:86128447-86167959 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033651
 protein coding gene Chr9:88784892-88820053 (-)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    MTHFS, methenyltetrahydrofolate synthetase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MTHFS, methenyltetrahydrofolate synthetase
  • Synonyms
    HsT19268, NEDMEHM
  • Links
    NCBI Gene ID: 10588
    neXtProt AC: NX_P49914
    UniProt: P49914

  • Chr Location
    15q25.1; chr15:79833585-79897379 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    826
  • Tissues
    110
  • cDNA Data
    6
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000079427 Ensembl Gene Model | MGI Sequence Detail 31695 C57BL/6J ±  kb
    transcript ENSMUST00000113110 Ensembl | MGI Sequence Detail 801 Not Applicable  
    polypeptide ENSMUSP00000108734 Ensembl | MGI Sequence Detail 203 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • EC
      6.3.3.2
    • InterPro Domains
      IPR002698 5-formyltetrahydrofolate cyclo-ligase
      IPR024185 5-formyltetrahydrofolate cyclo-ligase-like domain superfamily
      IPR037171 NagB/RpiA transferase-like
    Molecular
    Reagents
    less
    • All nucleic 8
      cDNA 7
      Primer pair 1

      Microarray probesets 1
    References
    more
    • Summaries
      All 23
      Developmental Gene Expression 5
      Gene Ontology 2
      Phenotypes 8
    • Earliest
      J:122989 Visel A, et al., GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory