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Frem2 Gene Detail
Summary
  • Symbol
    Frem2
  • Name
    Fras1 related extracellular matrix protein 2
  • Synonyms
    6030440P17Rik, 8430406N05Rik, b2b1562Clo, my, ne
  • Feature Type
    protein coding gene
  • IDs
    MGI:2444465
    NCBI Gene: 242022
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:53421359-53564776 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 25.24 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    5137 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2444465
 protein coding gene Chr3:53421359-53566014 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027208
 protein coding gene Chr3:52113975-52264280 (-)
A/J MGP_AJ_G0027168
 protein coding gene Chr3:50542889-50688822 (-)
AKR/J MGP_AKRJ_G0027137
 protein coding gene Chr3:51567228-51716920 (-)
BALB/cJ MGP_BALBcJ_G0027180
 protein coding gene Chr3:50409902-50553523 (-)
C3H/HeJ MGP_C3HHeJ_G0026923
 protein coding gene Chr3:51795804-51946393 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027626
 protein coding gene Chr3:54138565-54298022 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024986
 protein coding gene Chr3:47119581-47263359 (-)
CAST/EiJ MGP_CASTEiJ_G0026376
 protein coding gene Chr3:51892548-52041338 (-)
CBA/J MGP_CBAJ_G0026900
 protein coding gene Chr3:55848686-56018661 (-)
DBA/2J MGP_DBA2J_G0027034
 protein coding gene Chr3:50125390-50269347 (-)
FVB/NJ MGP_FVBNJ_G0027002
 protein coding gene Chr3:49102561-49248319 (-)
LP/J MGP_LPJ_G0027146
 protein coding gene Chr3:52846250-53000245 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027020
 protein coding gene Chr3:59959231-60132987 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027685
 protein coding gene Chr3:51474864-51625895 (-)
PWK/PhJ MGP_PWKPhJ_G0026108
 protein coding gene Chr3:49785435-49930625 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025921
 protein coding gene Chr3:51193834-51350410 (-)
WSB/EiJ MGP_WSBEiJ_G0026450
 protein coding gene Chr3:51587109-51734625 (-)



Homology
more
  • Human Ortholog
    FREM2, FRAS1 related extracellular matrix 2
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FREM2, FRAS1 related extracellular matrix 2
  • Synonyms
    CRYPTOP, FRASRS2
  • Links
    NCBI Gene ID: 341640
    neXtProt AC: NX_Q5SZK8
    UniProt: Q5SZK8

  • Chr Location
    13q13.3; chr13:38687077-38887131 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with Frem2 mouse models; 2 with human FREM2 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
 View 6 models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    7 with disease annotations
  • References
    7 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    60 phenotypes from 9 alleles in 10 genetic backgrounds
    5 phenotypes from multigenic genotypes
    16 images
    41 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for mutations at this locus display a significant amount of embryonic lethality due to hemorrhaging of embryonic blisters. Kidney development is severely affected and syndactyly is common. Phenotypes of homozygous mutants are indistinguishable from those of Fras1 homozygous mutant.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1049
  • Tissues
    130
  • cDNA Data
    59
  • Literature Summary
    23
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000037016 Ensembl Gene Model | MGI Sequence Detail 143418 C57BL/6J ±  kb
    transcript ENSMUST00000091137 Ensembl | MGI Sequence Detail 12348 Not Applicable  
    polypeptide ENSMUSP00000088670 Ensembl | MGI Sequence Detail 3160 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000007657 FRAS1-related extracellular matrix protein 2
      (term hierarchy)
    • InterPro Domains
      IPR038081 CalX-like domain superfamily
      IPR039005 CSPG repeat
      IPR051561 FRAS1-related extracellular matrix
      IPR045658 FRAS1-related extracellular matrix protein, N-terminal domain
      IPR003644 Na-Ca exchanger/integrin-beta4
    • GlyGen
      Q6NVD0 11 sites, 6 N-linked glycans (7 sites), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 67
      cDNA 59
      Primer pair 5
      Other 3

      Microarray probesets 1
    Other
    Accession IDs
    less
    MGD-MRK-12734, MGI:1918727, MGI:3794301, MGI:5429775, MGI:97248
    References
    more
    • Summaries
      All 83
      Developmental Gene Expression 23
      Diseases 7
      Gene Ontology 16
      Phenotypes 41
    • Earliest
      J:14847 Little CC, et al., The occurrence of two heritable types of abnormality among descendants of X-rayed mice. Am J Roentgenol. 1923;10:975-989
    • Latest
      J:335095 Lipp SN, et al., FOXD1 is required for 3D patterning of the kidney interstitial matrix. Dev Dyn. 2023 Apr;252(4):463-482
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory