Duxf2 Pseudogene Detail

Summary

• Symbol
  Duxf2
• Name
  double homeobox family member 2
• Synonyms
  Gm10807

• Feature Type
  pseudogene
• IDs
  MGI:3798168
  NCBI Gene: 100502899
• Alliance
  gene page

Location &
Maps

• Sequence Map
  Chr10:58063679-58064473 bp, - strand

  From Ensembl annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 10, 29.29 cM

Strain
Comparison

• SNPs within 2kb
  24 from dbSNP Build 142
• Strain Annotations
  3

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3798168	pseudogene	Chr10:58063679-58064486 (-)
129S1/SvImJ	no annotation
A/J	no annotation
AKR/J	no annotation
BALB/cJ	no annotation
C3H/HeJ	no annotation
C57BL/6NJ	no annotation
CAROLI/EiJ	no annotation
CAST/EiJ	no annotation
CBA/J	MGP_CBAJ_G0039547	pseudogene	Chr10:61534514-61538974 (-)
DBA/2J	no annotation
FVB/NJ	no annotation
LP/J	no annotation
NOD/ShiLtJ	no annotation
NZO/HlLtJ	MGP_NZOHlLtJ_G0040599	pseudogene	Chr10:56911366-56912057 (-)
PWK/PhJ	no annotation
SPRET/EiJ	no annotation
WSB/EiJ	no annotation

Homology

• Gene Tree
  Duxf2
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  1 phenotype from multigenic genotypes
  8 phenotype references
  

• All Mutations and Alleles
  3
• Chemically induced (other)
  1
• Endonuclease-mediated
  1
• Radiation induced
  1
• Genomic Mutations
  2 involving Duxf2
• Find Mice (IMSR)
  0 strains or lines available

Mice homozygous for null alleles in each genes of the Dux cluster exhibit delayed zygotic gene activation and decreased development potential of embryos.

Expression

• Assay Results
  706

Tissue x Stage Matrix

• Other Mouse Links
  Expression Atlas

Sequences &
Gene Models

• All Sequences
  7
• RefSeq
  1

• Ensembl
  ENSMUSG00000057216 (Evidence)
• NCBI Gene
  100502899

Representative Sequences			Length	Strain/Species
genomic	ENSMUSG00000057216	Ensembl Gene Model | MGI Sequence Detail	795	C57BL/6J
transcript	ENSMUST00000177134	Ensembl | MGI Sequence Detail	795	Not Applicable

Other
Accession IDs

MGI:7539549

References

• Summaries
  All 12

  Phenotypes 8
• Earliest
  J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
• Latest
  J:353213 Yang G, et al., Dux-Mediated Corrections of Aberrant H3K9ac during 2-Cell Genome Activation Optimize Efficiency of Somatic Cell Nuclear Transfer. Cell Stem Cell. 2021 Jan 7;28(1):150-163.e5