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Sprr2a2 Gene Detail
Summary
  • Symbol
    Sprr2a2
  • Name
    small proline-rich protein 2A2
  • Feature Type
    protein coding gene
  • IDs
    MGI:3845026
    NCBI Gene: 100303744
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr3:92157982-92164610 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 40.14 cM
Strain
Comparison
more
  • SNPs within 2kb
    1 from dbSNP Build 142
  • Strain Annotations
    7
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3845026
 protein coding gene Chr3:92123227-92164610 (+)
129S1/SvImJ no annotation
A/J MGP_AJ_G0027454
 protein coding gene Chr3:89763334-89766482 (+)
AKR/J MGP_AKRJ_G0027420
 protein coding gene Chr3:91944052-91944759 (+)
BALB/cJ MGP_BALBcJ_G0027462
 protein coding gene Chr3:89530497-89618886 (+)
C3H/HeJ no annotation
C57BL/6NJ no annotation
CAROLI/EiJ no annotation
CAST/EiJ no annotation
CBA/J no annotation
DBA/2J no annotation
FVB/NJ no annotation
LP/J no annotation
NOD/ShiLtJ MGP_NODShiLtJ_G0027306
 protein coding gene Chr3:105793845-105798382 (+)
NZO/HlLtJ no annotation
PWK/PhJ MGP_PWKPhJ_G0026384
 protein coding gene Chr3:88996182-89006447 (+)
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0026732
 protein coding gene Chr3:91924569-91929389 (+)



Homology
less
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotype references
  • All Mutations and Alleles
    3
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    1
  • Radiation induced
    1
  • Genomic Mutations
    3 involving Sprr2a2
  • Find Mice (IMSR)
    0 strains or lines available
Gene Ontology
(GO)
Classifications
less
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

No experimental evidence to support Cellular Component annotation, following literature review. See J:73796.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    714
  • Tissues
    2
  • cDNA Data
    7
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 100303744 NCBI Gene Model | MGI Sequence Detail 6629 C57BL/6J ±  kb
transcript NM_001164787 RefSeq | MGI Sequence Detail 3518 C57BL/6  
polypeptide NP_001158259 RefSeq | MGI Sequence Detail 83 C57BL/6  
For the selected sequence
Molecular
Reagents
less
  • All nucleic 8
    cDNA 8
References
more
  • Summaries
    All 15
    Developmental Gene Expression 1
    Diseases 1
    Phenotypes 6
  • Earliest
    J:52302 Song HJ, et al., Mouse Sprr2 genes: a clustered family of genes showing differential expression in epithelial tissues. Genomics. 1999 Jan 1;55(1):28-42
  • Latest
    J:325777 Zhang C, et al., Small proline-rich proteins (SPRRs) are epidermally produced antimicrobial proteins that defend the cutaneous barrier by direct bacterial membrane disruption. Elife. 2022 Mar 2;11:e76729
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory