Dp(17Abcg1-Cbs)1Yah Cytogenetic Marker Detail

Summary

• Symbol
  Dp(17Abcg1-Cbs)1Yah
• Name
  duplication, Chr 17, Yann Herault 1
• Synonyms
  Dp(17Abcg1-U2af1)1Yah

• Feature Type
  chromosomal duplication
• IDs
  MGI:4367903

Location &
Maps

• Sequence Map
  Chr17:31276672-31856173 bp

  From MGI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 17, Syntenic

Human Diseases

• Diseases
  1 with Dp(17Abcg1-Cbs)1Yah mouse models

Human Disease

Mouse Models

Down syndrome

IDs

Down syndrome      

DOID:14250
ICD10CM:Q90
ICD9CM:758.0
MESH:D004314
NCI:C2993
OMIM:190685
ORDO:870
UMLS_CUI:C0013080

View 1 model

Mouse Models

Human Disease Modeled: Down syndrome

Allelic Composition	Genetic Background	Reference	Phenotypes
Dp(17Abcg1-Cbs)1Yah/0	B6.129P2-Dp(17Abcg1-Cbs1)1Yah	J:154298	View

Click on a disease name to see all genes associated with that disease.

• Mutations/Alleles
  1 with disease annotations

• References
  1 with disease annotations

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  8 phenotypes from 1 allele in 1 genetic background
  4 phenotype references
  

• All Mutations and Alleles
  1
• Targeted
  1
• Find Mice (IMSR)
  1 strains or lines available

References

• Summaries
  All 5

  Diseases 1

  Phenotypes 4
• Earliest
  J:154298 Pereira PL, et al., A new mouse model for the trisomy of the Abcg1-U2af1 region reveals the complexity of the combinatorial genetic code of down syndrome. Hum Mol Genet. 2009 Dec 15;18(24):4756-4769
• Latest
  J:273645 Marechal D, et al., Cbs overdosage is necessary and sufficient to induce cognitive phenotypes in mouse models of Down syndrome and interacts genetically with Dyrk1a. Hum Mol Genet. 2019 May 1;28(9):1561-1577