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Del(7Mrgpra1-Mrgprb4)1And Cytogenetic Marker Detail
Summary
  • Symbol
    Del(7Mrgpra1-Mrgprb4)1And
  • Name
    deletion, Chr 7, David J Anderson 1
  • Synonyms
    Mrgpr-cluster delta-
  • Feature Type
    chromosomal deletion
  • IDs
    MGI:4436906
Location &
Maps
more
  • Sequence Map
    Chr7:46984623-47848926 bp
    From MGI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, Syntenic
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
The deletion of 845 kb, which removes 12 Mrgprs, results in decreased chloroquine-induced pruritus.
References
more
  • Summaries
    All 14
    Phenotypes 14
  • Earliest
    J:157470 Liu Q, et al., Sensory neuron-specific GPCR Mrgprs are itch receptors mediating chloroquine-induced pruritus. Cell. 2009 Dec 24;139(7):1353-65
  • Latest
    J:343323 Deng L, et al., S. aureus drives itch and scratch-induced skin damage through a V8 protease-PAR1 axis. Cell. 2023 Nov 22;186(24):5375-5393.e25
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory