Ighv1-66 MGI Mouse Gene Detail - MGI:4439825 - immunoglobulin heavy variable 1-66

Symbol

Ighv1-66
Name

immunoglobulin heavy variable 1-66
Synonyms

Gm16901

Feature Type

gene segment
IDs

MGI:4439825
NCBI Gene: 380824
Alliance

gene page

Sequence Map

Chr12:115556730-115557023 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 62.59 cM
Mapping Data

1 experiment

SNPs within 2kb

248 from dbSNP Build 142
Strain Annotations

12

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_4439825	gene segment	Chr12:115556730-115557211 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0000099	gene segment	Chr12:118781663-118782140 (-)
A/J	no annotation
AKR/J	MGP_AKRJ_G0000103	gene segment	Chr12:117956804-117957281 (-)
BALB/cJ	no annotation
C3H/HeJ	MGP_C3HHeJ_G0000098	gene segment	Chr12:118236936-118237413 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0000135	gene segment	Chr12:122382047-122382528 (-)
CAROLI/EiJ	no annotation
CAST/EiJ	MGP_CASTEiJ_G0000103	gene segment	Chr12:112070276-112070754 (-)
CBA/J	MGP_CBAJ_G0000095	gene segment	Chr12:127471348-127471825 (-)
DBA/2J	no annotation
FVB/NJ	MGP_FVBNJ_G0000088	gene segment	Chr12:112548055-112548532 (-)
LP/J	MGP_LPJ_G0000106	gene segment	Chr12:118874474-118874951 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0000099	gene segment	Chr12:130270091-130801149 (-)
NZO/HlLtJ	no annotation
PWK/PhJ	MGP_PWKPhJ_G0000086	gene segment	Chr12:108594723-108595201 (-)
SPRET/EiJ	no annotation
WSB/EiJ	MGP_WSBEiJ_G0000103	gene segment	Chr12:118083423-118083901 (-)

Human Ortholog

IGHV1-18, immunoglobulin heavy variable 1-18

Vertebrate Orthologs

16

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

IGHV1-18, immunoglobulin heavy variable 1-18
Synonyms

IGHV118
Links

HGNC:5549

NCBI Gene ID: 28468

UniProt: A0A0C4DH31
Chr Location

14q32.33; chr14:106184899-106185394 (-) GRCh38

Human Ortholog

IGHV1-2, immunoglobulin heavy variable 1-2
Synonyms

IGHV12, V35
Links

HGNC:5550

NCBI Gene ID: 28474
Chr Location

14q32.33; chr14:105986582-105987083 (-) GRCh38

Human Ortholog

IGHV1-24, immunoglobulin heavy variable 1-24
Synonyms

IGHV124, VH
Links

HGNC:5551

NCBI Gene ID: 28467

UniProt: A0A0C4DH33
Chr Location

14q32.33; chr14:106276546-106277043 (-) GRCh38

Human Ortholog

IGHV1-3, immunoglobulin heavy variable 1-3
Synonyms

IGHV13, VI-3B
Links

HGNC:5552

NCBI Gene ID: 28473

UniProt: A0A0C4DH29
Chr Location

14q32.33; chr14:106005095-106005574 (-) GRCh38

Human Ortholog

IGHV1-38-4, immunoglobulin heavy variable 1-38-4 (non-functional)
Synonyms

IGHV1-C, IGHV1C
Links

HGNC:5560

NCBI Gene ID: 28460

UniProt: P0DTW3
Chr Location

14q32.33

Human Ortholog

IGHV1-45, immunoglobulin heavy variable 1-45
Synonyms

IGHV145, VH
Links

HGNC:5553

NCBI Gene ID: 28466

UniProt: A0A0A0MS14
Chr Location

14q32.33; chr14:106506996-106507491 (-) GRCh38

Human Ortholog

IGHV1-46, immunoglobulin heavy variable 1-46
Synonyms

IGHV146
Links

HGNC:5554

NCBI Gene ID: 28465
Chr Location

14q32.33; chr14:106511115-106511856 (-) GRCh38

Human Ortholog

IGHV1-58, immunoglobulin heavy variable 1-58
Synonyms

IGHV158, VH
Links

HGNC:5555

NCBI Gene ID: 28464

UniProt: A0A0C4DH39
Chr Location

14q32.33; chr14:106622357-106622855 (-) GRCh38

Human Ortholog

IGHV1-69, immunoglobulin heavy variable 1-69
Synonyms

IGHV169, IGHV1-E, IGHV1E
Links

HGNC:5558

NCBI Gene ID: 28461

UniProt: P01742
Chr Location

14q32.33; chr14:106714682-106715181 (-) GRCh38

Human Ortholog

IGHV1-69-2, immunoglobulin heavy variable 1-69-2
Synonyms

IGHV1-F, IGHV1F
Links

HGNC:5562

NCBI Gene ID: 28458

UniProt: A0A0G2JMI3
Chr Location

14q32.33; chr14:106737110-106737547 (-) GRCh38

Human Ortholog

IGHV1-69D, immunoglobulin heavy variable 1-69D
Links

HGNC:49601

NCBI Gene ID: 102723169

UniProt: A0A0B4J2H0
Chr Location

14q32.33; chr14:106762092-106762588 (-) GRCh38

Human Ortholog

IGHV1OR15-1, immunoglobulin heavy variable 1/OR15-1 (non-functional)
Synonyms

IGHV1/OR15-1, IGHV1OR151
Links

HGNC:5563

NCBI Gene ID: 388077
Chr Location

15q11.2

Human Ortholog

IGHV1OR15-9, immunoglobulin heavy variable 1/OR15-9 (non-functional)
Synonyms

IGHV1OR159, VSIG7
Links

HGNC:5569

NCBI Gene ID: 390531
Chr Location

15q11.1

Human Ortholog

IGHV1OR21-1, immunoglobulin heavy variable 1/OR21-1 (non-functional)
Links

HGNC:38040

NCBI Gene ID: 390530
Chr Location

21p11.2; chr21:10649390-10649835 (-) GRCh38

MGI Vertebrate Homology

Ighv1-66 stringent orthology
14 human;1 mouse;2 zebrafish
HCOP

vertebrate homology predictions: IGHV1-18, IGHV1-2, IGHV1-24, IGHV1-3, IGHV1-38-4, IGHV1-45, IGHV1-46, IGHV1-58, IGHV1-69, IGHV1-69-2, IGHV1-69D, IGHV1OR15-1, IGHV1OR15-9, IGHV1OR21-1
Gene Tree

Ighv1-66

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Incidental Mutations

APF
Find Mice (IMSR)

8 strains or lines available

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All GO Annotations

2
GO References

1

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706

Tissue x Stage Matrix

Other Mouse Links

GEO

Expression Atlas

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All Sequences

18
RefSeq

1
UniProt

1

Ensembl

ENSMUSG00000095519 (Evidence)
NCBI Gene

380824

Representative Sequences				Length	Strain/Species	Flank
	genomic	380824	NCBI Gene Model \| MGI Sequence Detail	294	C57BL/6J	± kb
	polypeptide	A0A075B5X5	UniProt \| EBI \| MGI Sequence Detail	117	Not Applicable

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UniProt

1 Sequence
InterPro Domains

IPR050199 Immunoglobulin Heavy Variable

IPR007110 Immunoglobulin-like domain

IPR036179 Immunoglobulin-like domain superfamily

IPR013783 Immunoglobulin-like fold

IPR013106 Immunoglobulin V-set domain

Summaries

All 6

Gene Ontology 1
Earliest

J:164272 Giudicelli V, et al., IMGT/GENE-DB: a comprehensive database for human and mouse immunoglobulin and T cell receptor genes. Nucleic Acids Res. 2005 Jan 1;33(Database issue):D256-61

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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