Ighv5-9 MGI Mouse Gene Detail - MGI:4439873 - immunoglobulin heavy variable 5-9

Symbol

Ighv5-9
Name

immunoglobulin heavy variable 5-9
Synonyms

Gm16949

Feature Type

gene segment
IDs

MGI:4439873
NCBI Gene: 544896
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr12:113625391-113625848 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 62.15 cM
Mapping Data

1 experiment

SNPs within 2kb

61 from dbSNP Build 142
Strain Annotations

11

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_4439873	gene segment	Chr12:113625389-113625913 (-)
129S1/SvImJ	no annotation
A/J	no annotation
AKR/J	no annotation
BALB/cJ	no annotation
C3H/HeJ	no annotation
C57BL/6NJ	MGP_C57BL6NJ_G0000059	gene segment	Chr12:119777338-119777862 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0000033	gene segment	Chr12:108383739-108384267 (-)
CAST/EiJ	MGP_CASTEiJ_G0000053	gene segment	Chr12:110451381-110477310 (-)
CBA/J	no annotation
DBA/2J	MGP_DBA2J_G0000047	gene segment	Chr12:111305266-111305796 (-)
FVB/NJ	MGP_FVBNJ_G0000043	gene segment	Chr12:110052576-110053100 (-)
LP/J	MGP_LPJ_G0000050	gene segment	Chr12:116249426-116250083 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0000047	gene segment	Chr12:127499242-127499766 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0000056	gene segment	Chr12:114537603-114538133 (-)
PWK/PhJ	no annotation
SPRET/EiJ	MGP_SPRETEiJ_G0000040	gene segment	Chr12:108696669-108697657 (-)
WSB/EiJ	MGP_WSBEiJ_G0000047	gene segment	Chr12:115580676-115581206 (+)

Human Ortholog

IGHV3-13, immunoglobulin heavy variable 3-13

Vertebrate Orthologs

20

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

IGHV3-13, immunoglobulin heavy variable 3-13
Synonyms

IGHV313
Links

HGNC:5581

NCBI Gene ID: 28449

UniProt: P01766
Chr Location

14q32.33; chr14:106129540-106130072 (-) GRCh38

Human Ortholog

IGHV3-20, immunoglobulin heavy variable 3-20
Synonyms

IGHV320, VH
Links

HGNC:5585

NCBI Gene ID: 28445

UniProt: A0A0C4DH32
Chr Location

14q32.33; chr14:106210936-106211453 (-) GRCh38

Human Ortholog

IGHV3-23, immunoglobulin heavy variable 3-23
Synonyms

DP47, IGHV323, V3-23, VH26
Links

HGNC:5588

NCBI Gene ID: 28442

UniProt: P01764
Chr Location

14q32.33; chr14:106268606-106269140 (-) GRCh38

Human Ortholog

IGHV3-30, immunoglobulin heavy variable 3-30
Synonyms

IGHV330, VH
Links

HGNC:5591

NCBI Gene ID: 28439

UniProt: P01768
Chr Location

14q32.33; chr14:106335080-106335613 (-) GRCh38

Human Ortholog

IGHV3-30-3, immunoglobulin heavy variable 3-30-3
Synonyms

IGHV3-3, IGHV3303
Links

HGNC:5593

NCBI Gene ID: 57290

UniProt: P0DP02
Chr Location

14q32.33

Human Ortholog

IGHV3-30-5, immunoglobulin heavy variable 3-30-5
Synonyms

IGHV3-3, IGHV3305
Links

HGNC:5594

NCBI Gene ID: 89770

UniProt: P0DP03
Chr Location

14q32.33

Human Ortholog

IGHV3-33, immunoglobulin heavy variable 3-33
Synonyms

IGHV333, VH
Links

HGNC:5596

NCBI Gene ID: 28434

UniProt: P01772
Chr Location

14q32.33; chr14:106359791-106360324 (-) GRCh38

Human Ortholog

IGHV3-35, immunoglobulin heavy variable 3-35 (non-functional)
Synonyms

IGHV335, VH
Links

HGNC:5598

NCBI Gene ID: 28432

UniProt: A0A0C4DH35
Chr Location

14q32.33; chr14:106389390-106389858 (-) GRCh38

Human Ortholog

IGHV3-38, immunoglobulin heavy variable 3-38 (non-functional)
Synonyms

IGHV338, VH
Links

HGNC:5601

NCBI Gene ID: 28429

UniProt: A0A0C4DH36
Chr Location

14q32.33; chr14:106410493-106411021 (-) GRCh38

Human Ortholog

IGHV3-38-3, immunoglobulin heavy variable 3-38-3 (non-functional)
Synonyms

IGH, IGHV3-D, IGHV3D
Links

HGNC:5629

NCBI Gene ID: 28404

UniProt: P0DTE1
Chr Location

14q32.33

Human Ortholog

IGHV3-43, immunoglobulin heavy variable 3-43
Synonyms

IGHV343, VH
Links

HGNC:5604

NCBI Gene ID: 28426

UniProt: A0A0B4J1X8
Chr Location

14q32.33; chr14:106470263-106470800 (-) GRCh38

Human Ortholog

IGHV3-53, immunoglobulin heavy variable 3-53
Synonyms

IGHV353, VH
Links

HGNC:5610

NCBI Gene ID: 28420

UniProt: P01767
Chr Location

14q32.33; chr14:106592676-106593347 (-) GRCh38

Human Ortholog

IGHV3-64, immunoglobulin heavy variable 3-64
Synonyms

IGHV364, VH
Links

HGNC:5617

NCBI Gene ID: 28414

UniProt: A0A075B6Q5
Chr Location

14q32.33; chr14:106657723-106658258 (-) GRCh38

Human Ortholog

IGHV3-64D, immunoglobulin heavy variable 3-64D
Links

HGNC:49603

NCBI Gene ID: 102723170

UniProt: A0A0J9YX35
Chr Location

14q32.33; chr14:106088122-106088573 (-) GRCh38

Human Ortholog

IGHV3-66, immunoglobulin heavy variable 3-66
Synonyms

IGHV366, VH
Links

HGNC:5619

NCBI Gene ID: 28412

UniProt: A0A0C4DH42
Chr Location

14q32.33; chr14:106675015-106675544 (-) GRCh38

Human Ortholog

IGHV3-74, immunoglobulin heavy variable 3-74
Synonyms

IGHV374, VH
Links

HGNC:5624

NCBI Gene ID: 28408

UniProt: A0A0B4J1X5
Chr Location

14q32.33; chr14:106810440-106811131 (-) GRCh38

Human Ortholog

IGHV3-9, immunoglobulin heavy variable 3-9
Synonyms

IGHV39, VH
Links

HGNC:5628

NCBI Gene ID: 28451

UniProt: P01782
Chr Location

14q32.33

Human Ortholog

IGHV3OR16-10, immunoglobulin heavy variable 3/OR16-10 (non-functional)
Synonyms

IGHV3OR1610
Links

HGNC:5634

NCBI Gene ID: 28306
Chr Location

16p11.2; chr16:32995048-32995505 (+) GRCh38

Human Ortholog

IGHV3OR16-8, immunoglobulin heavy variable 3/OR16-8 (non-functional)
Synonyms

IGHV3/OR16-8, IGHV3OR168
Links

HGNC:5643

NCBI Gene ID: 388255
Chr Location

16p11.2

MGI Vertebrate Homology

Ighv5-9 stringent orthology
19 human;1 mouse;1 zebrafish
HCOP

vertebrate homology predictions: IGHV3-13, IGHV3-20, IGHV3-23, IGHV3-30, IGHV3-30-3, IGHV3-30-5, IGHV3-33, IGHV3-35, IGHV3-38, IGHV3-38-3, IGHV3-43, IGHV3-53, IGHV3-64, IGHV3-64D, IGHV3-66, IGHV3-74, IGHV3-9, IGHV3OR16-10, IGHV3OR16-8
Gene Tree

Ighv5-9

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All GO Annotations

2
GO References

1

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706

Tissue x Stage Matrix

Other Mouse Links

GEO

Expression Atlas

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All Sequences

20
RefSeq

1
UniProt

2

Ensembl

ENSMUSG00000095285 (Evidence)
NCBI Gene

544896

			Length	Strain/Species	Flank
genomic	544896	NCBI Gene Model \| MGI Sequence Detail	458	C57BL/6J	± kb
transcript	X51721	GenBank \| ENA \| DDBJ \| MGI Sequence Detail	480	BALB/c, Ag8.653 myeloma*
polypeptide	A2NV20	UniProt \| EBI \| MGI Sequence Detail	138	Not Applicable

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UniProt

2 Sequences
InterPro Domains

IPR050199 Immunoglobulin Heavy Variable

IPR007110 Immunoglobulin-like domain

IPR036179 Immunoglobulin-like domain superfamily

IPR013783 Immunoglobulin-like fold

IPR003599 Immunoglobulin subtype

IPR013106 Immunoglobulin V-set domain

Summaries

All 11

Gene Ontology 1
Earliest

J:7258 Ollo R, et al., Structural relationships among mouse and human immunoglobulin VH genes in the subgroup III. Nucleic Acids Res. 1983 Nov 25;11(22):7887-97
Latest

J:164272 Giudicelli V, et al., IMGT/GENE-DB: a comprehensive database for human and mouse immunoglobulin and T cell receptor genes. Nucleic Acids Res. 2005 Jan 1;33(Database issue):D256-61

TSS for Ighv5-9:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr118045	Chr12:113625913-113625929 (-)	-73 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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