H4c18 Gene Detail

Summary

• Symbol
  H4c18
• Name
  H4 clustered histone 18
• Synonyms
  Hist1h4n

• Feature Type
  protein coding gene
• IDs
  MGI:4843992
  NCBI Gene: 319161
• Member of
  Hist1 cluster
• Alliance
  gene page
• Transcription Start Sites
  1 TSS

Location &
Maps

• Sequence Map
  Chr13:22015962-22016367 bp, - strand

  From NCBI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 13, 8.00 cM

Strain
Comparison

• SNPs within 2kb
  81 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_4843992	protein coding gene	Chr13:22015937-22016367 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0020302	protein coding gene	Chr13:19129012-19131254 (-)
A/J	MGP_AJ_G0020259	protein coding gene	Chr13:18696422-18696851 (-)
AKR/J	MGP_AKRJ_G0020233	protein coding gene	Chr13:18987225-18987654 (+)
BALB/cJ	MGP_BALBcJ_G0020246	protein coding gene	Chr13:18746215-18746644 (-)
C3H/HeJ	MGP_C3HHeJ_G0020056	protein coding gene	Chr13:19112535-19112964 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0020685	protein coding gene	Chr13:19803170-19803590 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018298	protein coding gene	Chr13:17206876-17207290 (-)
CAST/EiJ	MGP_CASTEiJ_G0019580	protein coding gene	Chr13:18904195-19135444 (-)
CBA/J	MGP_CBAJ_G0020010	protein coding gene	Chr13:20468538-20471338 (-)
DBA/2J	MGP_DBA2J_G0020133	protein coding gene	Chr13:18340306-18340735 (-)
FVB/NJ	MGP_FVBNJ_G0020120	protein coding gene	Chr13:17980155-17980577 (-)
LP/J	MGP_LPJ_G0020203	protein coding gene	Chr13:19353250-19353679 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020156	protein coding gene	Chr13:21105911-21106310 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020719	protein coding gene	Chr13:18804788-18805217 (+)
PWK/PhJ	MGP_PWKPhJ_G0019341	protein coding gene	Chr13:18575597-18576233 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0019153	protein coding gene	Chr13:18039644-18040005 (-)
WSB/EiJ	MGP_WSBEiJ_G0019641	protein coding gene	Chr13:18930896-19165296 (-)

Homology

• Human Ortholog
  H4C13, H4 clustered histone 13

• Vertebrate Orthologs
  16

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  H4C13, H4 clustered histone 13
  
• Synonyms
  H4-16, H4C1, H4C11, H4C12, H4C14, H4C15, H4C16, H4C2, H4C3, H4C4, H4C5, H4C6, H4C8, H4C9, H4FK, H4.k, H4/k, HIST1H4L
• Links
  HGNC:4791

  NCBI Gene ID: 8368

  neXtProt AC: NX_P62805

  UniProt: P62805

  
  
• Chr Location
  6p22.1; chr6:27873148-27873534 (-)  GRCh38

---

• Human Ortholog
  H4C5, H4 clustered histone 5
  
• Synonyms
  H4-16, H4C1, H4C11, H4C12, H4C13, H4C14, H4C15, H4C16, H4C2, H4C3, H4C4, H4C6, H4C8, H4C9, H4FJ, H4/j, HIST1H4E, TEBIVANED3, TEVANED3
• Links
  HGNC:4790

  NCBI Gene ID: 8367

  neXtProt AC: NX_P62805

  UniProt: P62805

  
  
• Chr Location
  6p22.2; chr6:26204610-26205021 (+)  GRCh38

---

• MGI Vertebrate Homology
  H4c18 stringent orthology
  2 human;1 mouse;4 rat;10 zebrafish
  
• HCOP
  vertebrate homology predictions: H4C13, H4C5
• Gene Tree
  H4c18
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  8 phenotype references
  

• All Mutations and Alleles
  2
• Chemically induced (other)
  1
• Radiation induced
  1
• Genomic Mutations
  2 involving H4c18
• Find Mice (IMSR)
  1 strains or lines available

Expression

• Assay Results
  706
• cDNA Data
  2

Tissue x Stage Matrix

• Other Mouse Links
  GEO
  Expression Atlas

Sequences &
Gene Models

• All Sequences
  26
• RefSeq
  2
• CCDS
  CCDS26300.1

• Ensembl
  ENSMUSG00000069305 (Evidence)
• NCBI Gene
  319161

Representative Sequences			Length	Strain/Species
genomic	319161	NCBI Gene Model | MGI Sequence Detail	406	C57BL/6J
transcript	NM_175657	RefSeq | MGI Sequence Detail	406	C57BL/6
polypeptide	NP_783588	RefSeq | MGI Sequence Detail	103	C57BL/6

Molecular
Reagents

• All nucleic 2

  cDNA 2

Other
Accession IDs

MGI:6384987

References

• Summaries
  All 16

  Phenotypes 8
• Earliest
  J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
• Latest
  J:141688 Goldsworthy M, et al., Role of the transcription factor sox4 in insulin secretion and impaired glucose tolerance. Diabetes. 2008 Aug;57(8):2234-44

TSS for H4c18:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr121679	Chr13:22016364-22016368 (-)	1 bp