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Hivep2 Gene Detail
Summary
  • Symbol
    Hivep2
  • Name
    human immunodeficiency virus type I enhancer binding protein 2
  • Synonyms
    Gm20114, MIBP1, Schnurri-2, Shn-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1338076
    NCBI Gene: 15273
  • Alliance
    gene page
  • Transcription Start Sites
    24 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:13841819-14027118 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 5.14 cM, cytoband A2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4934 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1338076
 protein coding gene Chr10:13841819-14027122 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017026
 protein coding gene Chr10:11415352-11612357 (+)
A/J MGP_AJ_G0017004
 protein coding gene Chr10:10966157-11153454 (+)
AKR/J MGP_AKRJ_G0016968
 protein coding gene Chr10:11222629-11413370 (+)
BALB/cJ MGP_BALBcJ_G0016962
 protein coding gene Chr10:10992068-11181219 (+)
C3H/HeJ MGP_C3HHeJ_G0016787
 protein coding gene Chr10:11394647-11588098 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017424
 protein coding gene Chr10:11700288-11901805 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015129
 protein coding gene Chr10:10232215-10416737 (+)
CAST/EiJ MGP_CASTEiJ_G0016369
 protein coding gene Chr10:11272525-11468945 (+)
CBA/J MGP_CBAJ_G0016759
 protein coding gene Chr10:12160218-12364503 (+)
DBA/2J MGP_DBA2J_G0016867
 protein coding gene Chr10:10894528-11081629 (+)
FVB/NJ MGP_FVBNJ_G0016862
 protein coding gene Chr10:10715571-10902991 (+)
LP/J MGP_LPJ_G0016942
 protein coding gene Chr10:11259738-11454804 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016892
 protein coding gene Chr10:12034477-12233377 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017462
 protein coding gene Chr10:11124450-11317119 (+)
PWK/PhJ MGP_PWKPhJ_G0016154
 protein coding gene Chr10:10757500-10948021 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015937
 protein coding gene Chr10:11266315-11491611 (+)
WSB/EiJ MGP_WSBEiJ_G0016431
 protein coding gene Chr10:11164656-11360157 (+)



Homology
more
  • Human Ortholog
    HIVEP2, HIVEP zinc finger 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HIVEP2, HIVEP zinc finger 2
  • Synonyms
    HIV-EP2, MBP-2, MIBP1, MRD43, SHN2, ZAS2, ZNF40B
  • Links
    NCBI Gene ID: 3097
    neXtProt AC: NX_P31629
    UniProt: P31629

  • Chr Location
    6q24.2; chr6:142751469-142956698 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with Hivep2 mouse models; 1 with human HIVEP2 associations

Human Disease Mouse Models
      
IDs
 View 1 model
IDs
 View 2 models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    32 phenotypes from 1 allele in 4 genetic backgrounds
    3 phenotypes from multigenic genotypes
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele display abnormal thymus anatomy, severely defective positive selection of CD4+ and CD8+ cells, and enhanced T-helper 2 cell differentiation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    931
  • Tissues
    134
  • cDNA Data
    22
  • Literature Summary
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000015501 Ensembl Gene Model | MGI Sequence Detail 185300 C57BL/6J ±  kb
    transcript ENSMUST00000191138 Ensembl | MGI Sequence Detail 9846 Not Applicable  
    polypeptide ENSMUSP00000140150 Ensembl | MGI Sequence Detail 2430 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 22
      cDNA 22

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:5012299
    References
    more
    • Summaries
      All 55
      Developmental Gene Expression 10
      Diseases 2
      Gene Ontology 7
      Phenotypes 20
    • Earliest
      J:54634 Dorflinger U, et al., Activation of somatostatin receptor II expression by transcription factors MIBP1 and SEF-2 in the murine brain. Mol Cell Biol. 1999 May;19(5):3736-47
    • Latest
      J:278079 Murano T, et al., Transcriptomic immaturity inducible by neural hyperexcitation is shared by multiple neuropsychiatric disorders. Commun Biol. 2019;2:32
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory