About   Help   FAQ
Lrrc78 Gene Detail
Summary
  • Symbol
    Lrrc78
  • Name
    leucine rich repeat containing 78
  • Synonyms
    Gm28729
  • Feature Type
    protein coding gene
  • IDs
    MGI:5579435
    NCBI Gene: 102635744
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:96368054-96407317 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, Syntenic
Strain
Comparison
more
  • SNPs within 2kb
    1503 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_5579435
 protein coding gene Chr9:96368040-96407643 (-)
129S1/SvImJ MGP_129S1SvImJ_G0007486
 lincRNA gene Chr9:97715610-97722387 (-)
A/J MGP_AJ_G0007481
 lincRNA gene Chr9:94304796-94311158 (-)
AKR/J MGP_AKRJ_G0007453
 lincRNA gene Chr9:96611891-96618701 (-)
BALB/cJ MGP_BALBcJ_G0007458
 lincRNA gene Chr9:93987736-93994545 (-)
C3H/HeJ MGP_C3HHeJ_G0007403
 lincRNA gene Chr9:97010946-97017755 (-)
C57BL/6NJ MGP_C57BL6NJ_G0007630
 lincRNA gene Chr9:100514292-100521102 (-)
CAROLI/EiJ no annotation
CAST/EiJ MGP_CASTEiJ_G0007306
 lincRNA gene Chr9:96786340-96793226 (-)
CBA/J MGP_CBAJ_G0007384
 lincRNA gene Chr9:104016087-104022896 (-)
DBA/2J MGP_DBA2J_G0007410
 lincRNA gene Chr9:93825869-93832678 (-)
FVB/NJ MGP_FVBNJ_G0007426
 lincRNA gene Chr9:92673812-92680621 (-)
LP/J MGP_LPJ_G0007490
 lincRNA gene Chr9:97983607-97990416 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0007407
 lincRNA gene Chr9:106009371-106016181 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0007635
 lincRNA gene Chr9:96843909-96850864 (-)
PWK/PhJ MGP_PWKPhJ_G0007247
 lincRNA gene Chr9:94000056-94007051 (-)
SPRET/EiJ MGP_SPRETEiJ_G0007151
 lincRNA gene Chr9:96889534-96896776 (-)
WSB/EiJ MGP_WSBEiJ_G0007366
 lincRNA gene Chr9:96704575-96711385 (-)



Homology
more
  • Human Ortholog
    LRRC78P, leucine rich repeat containing 78, pseudogene
  • Vertebrate Orthologs
    1
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LRRC78P, leucine rich repeat containing 78, pseudogene
  • Synonyms
    LINC02618
  • Links
    NCBI Gene ID: 646730

  • Chr Location
    3q23; chr3:141660536-141729405 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotype references
  • All Mutations and Alleles
    4
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    1
  • Gene trapped
    2
  • Genomic Mutations
    1 involving Lrrc78
  • Find Mice (IMSR)
    7 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    8
  • GO References
    1
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000099564 Ensembl Gene Model | MGI Sequence Detail 39264 C57BL/6J ±  kb
transcript ENSMUST00000190704 Ensembl | MGI Sequence Detail 1964 Not Applicable  
polypeptide ENSMUSP00000148097 Ensembl | MGI Sequence Detail 409 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    1 Sequence
  • InterPro Domains
    IPR032675 Leucine-rich repeat domain superfamily
    IPR050637 NLRP family, innate immunity and inflammation regulators
Other
Accession IDs
less
MGI:7720868
References
more
  • Summaries
    All 14
    Gene Ontology 1
    Phenotypes 6
  • Earliest
    J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory