Exoc2 MGI Mouse Gene Detail - MGI:1913732 - exocyst complex component 2

Symbol

Exoc2
Name

exocyst complex component 2
Synonyms

2410030I24Rik, Sec5, Sec5l1

Feature Type

protein coding gene

BioType Conflict
IDs

MGI:1913732
NCBI Gene: 66482
Alliance

gene page
Transcription Start Sites

20 TSS

Sequence Map

Chr13:30968421-31162082 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, Syntenic
Mapping Data

3 experiments

SNPs within 2kb

4405 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1913732	protein coding gene	Chr13:30968416-31162082 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0020417	protein coding gene	Chr13:28700030-28869068 (-)
A/J	MGP_AJ_G0020372	protein coding gene	Chr13:27958020-28119400 (-)
AKR/J	MGP_AKRJ_G0020349	protein coding gene	Chr13:28563991-28724834 (-)
BALB/cJ	MGP_BALBcJ_G0020367	protein coding gene	Chr13:28041953-28174779 (-)
C3H/HeJ	MGP_C3HHeJ_G0020170	protein coding gene	Chr13:28577323-28741902 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0020803	protein coding gene	Chr13:29684617-29850348 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018394	protein coding gene	Chr13:26354377-26515058 (-)
CAST/EiJ	MGP_CASTEiJ_G0019687	protein coding gene	Chr13:28230636-28393737 (-)
CBA/J	MGP_CBAJ_G0020126	protein coding gene	Chr13:30944148-31130585 (-)
DBA/2J	MGP_DBA2J_G0020248	protein coding gene	Chr13:27489856-27650786 (-)
FVB/NJ	MGP_FVBNJ_G0020233	protein coding gene	Chr13:27093253-27254236 (-)
LP/J	MGP_LPJ_G0020325	protein coding gene	Chr13:28942210-29107716 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020259	protein coding gene	Chr13:31090777-31261295 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020844	protein coding gene	Chr13:28206291-28379781 (-)
PWK/PhJ	MGP_PWKPhJ_G0019442	protein coding gene	Chr13:27644411-27808275 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0019263	protein coding gene	Chr13:27119073-27285722 (-)
WSB/EiJ	MGP_WSBEiJ_G0019749	protein coding gene	Chr13:28516205-28680314 (-)

Human Ortholog

EXOC2, exocyst complex component 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

EXOC2, exocyst complex component 2
Synonyms

NEDFACH, SEC5, SEC5L1, Sec5p
Links

HGNC:24968

NCBI Gene ID: 55770

neXtProt AC: NX_Q96KP1

UniProt: Q96KP1
Chr Location

6p25.3; chr6:485154-693139 (-) GRCh38

MGI Vertebrate Homology

Exoc2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: EXOC2

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
1 images
19 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

26
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

21
Radiation induced

1
Genomic Mutations

2 involving Exoc2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

62 strains or lines available

Mice homozygous for a knock-out allele show complete embryonic lethality prior to organogenesis, and failure of blastocysts to hatch from the zona pellucida with increased cell death during outgrowth culture.

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All GO Annotations

23
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

807
Tissues

66
cDNA Data

80
Literature Summary

6

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase exoc2

ZFIN exoc2

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All Sequences

62
RefSeq

18
UniProt

2
CCDS

CCDS26420.1

Ensembl

ENSMUSG00000021357 (Evidence), ENSMUSG00000113515 (Evidence)
NCBI Gene

66482

			Length	Strain/Species	Flank
genomic	66482	NCBI Gene Model \| MGI Sequence Detail	193662	C57BL/6J	± kb
transcript	NM_001424702	RefSeq \| MGI Sequence Detail	8099	C57BL/6
polypeptide	Q9D4H1	UniProt \| EBI \| MGI Sequence Detail	924	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000007247 exocyst complex component 2

(term hierarchy)
PDB

1HK6
InterPro Domains

IPR029175 Exocyst complex component EXOC2/Sec5

IPR039481 Exocyst complex component EXOC2/Sec5, N-terminal domain

IPR014756 Immunoglobulin E-set

IPR013783 Immunoglobulin-like fold

IPR002909 IPT domain

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All nucleic 85

cDNA 81

Primer pair 3

Other 1

Microarray probesets 4

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MGI:2145277, MGI:5588834

Summaries

All 55

Developmental Gene Expression 6

Gene Ontology 10

Phenotypes 19
Earliest

J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Exoc2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr121978	Chr13:31158101-31158110 (-)	3,976 bp
Tssr121977	Chr13:31158031-31158081 (-)	4,026 bp
Tssr121976	Chr13:31158006-31158030 (-)	4,064 bp
Tssr121975	Chr13:31134297-31134308 (-)	27,779 bp
Tssr121974	Chr13:31081426-31081439 (-)	80,649 bp
Tssr121973	Chr13:31017539-31017550 (-)	144,537 bp
Tssr121972	Chr13:31004725-31004743 (-)	157,348 bp
Tssr121971	Chr13:31004717-31004722 (-)	157,362 bp
Tssr121970	Chr13:31004642-31004652 (-)	157,435 bp
Tssr121969	Chr13:31004615-31004626 (-)	157,461 bp
Tssr121968	Chr13:31004045-31004054 (-)	158,032 bp
Tssr121967	Chr13:31003788-31003793 (-)	158,291 bp
Tssr121966	Chr13:31001476-31001487 (-)	160,600 bp
Tssr4031	Chr13:30998304-30998311 (-)	163,774 bp
Tssr121965	Chr13:30978001-30978046 (-)	184,058 bp
Tssr121964	Chr13:30976280-30976287 (-)	185,798 bp
Tssr121963	Chr13:30976247-30976254 (-)	185,831 bp
Tssr121962	Chr13:30976233-30976244 (-)	185,843 bp
Tssr121961	Chr13:30976189-30976208 (-)	185,883 bp
Tssr121960	Chr13:30971656-30971665 (-)	190,421 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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