Pcdha4b Gene Detail

Summary

• Symbol
  Pcdha4b
• Name
  protocadherin alpha 4B
• Synonyms
  Gm37013

• Feature Type
  protein coding gene
• IDs
  MGI:5610241
  NCBI Gene: 100384868
• Alliance
  gene page

Location &
Maps

• Sequence Map
  Chr18:37085794-37973253 bp, + strand

  From Ensembl annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 18, Syntenic
• Mapping Data
  1 experiment

Strain
Comparison

• SNPs within 2kb
  24275 from dbSNP Build 142
• Strain Annotations
  1

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_5610241	protein coding gene	Chr18:37085701-37974926 (+)
129S1/SvImJ	no annotation
A/J	no annotation
AKR/J	no annotation
BALB/cJ	no annotation
C3H/HeJ	no annotation
C57BL/6NJ	no annotation
CAROLI/EiJ	no annotation
CAST/EiJ	no annotation
CBA/J	no annotation
DBA/2J	no annotation
FVB/NJ	no annotation
LP/J	no annotation
NOD/ShiLtJ	no annotation
NZO/HlLtJ	no annotation
PWK/PhJ	no annotation
SPRET/EiJ	no annotation
WSB/EiJ	no annotation

Homology

• Human Ortholog
  PCDHA4, protocadherin alpha 4

• Vertebrate Orthologs
  12

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  PCDHA4, protocadherin alpha 4
  
• Synonyms
  CNR1, CNRN1, CRNR1, PCDH-ALPHA4
• Links
  HGNC:8670

  NCBI Gene ID: 56144

  neXtProt AC: NX_Q9UN74

  UniProt: Q9UN74

  
  
• Chr Location
  5q31.3; chr5:140807037-141012347 (+)  GRCh38

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• MGI Vertebrate Homology
  Pcdha4b stringent orthology
  1 human;1 mouse;1 rat;10 zebrafish
  
• HCOP
  vertebrate homology predictions: PCDHA4
• Gene Tree
  Pcdha4b
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  2 phenotype references
  

• All Mutations and Alleles
  5
• Endonuclease-mediated
  1
• Targeted
  4
• Genomic Mutations
  5 involving Pcdha4b
• Find Mice (IMSR)
  0 strains or lines available

Expression

• Assay Results
  706

Tissue x Stage Matrix

• Other Mouse Links
  GEO
  Expression Atlas

Sequences &
Gene Models

• All Sequences
  14
• RefSeq
  2
• CCDS
  CCDS79616.1

• Ensembl
  ENSMUSG00000103458 (Evidence)
• NCBI Gene
  100384868

Representative Sequences			Length	Strain/Species
genomic	ENSMUSG00000103458	Ensembl Gene Model | MGI Sequence Detail	887460	C57BL/6J
transcript	ENSMUST00000115661	Ensembl | MGI Sequence Detail	2856	Not Applicable
polypeptide	ENSMUSP00000111325	Ensembl | MGI Sequence Detail	919	Not Applicable

Other
Accession IDs

MGI:7524750

References

• Summaries
  All 8

  Phenotypes 2
• Earliest
  J:78249 Wang X, et al., Molecular mechanisms governing Pcdh-gamma gene expression: evidence for a multiple promoter and cis-alternative splicing model. Genes Dev. 2002 Aug 1;16(15):1890-905
• Latest
  J:313451 Xu L, et al., Abnormal neocortex arealization and Sotos-like syndrome-associated behavior in Setd2 mutant mice. Sci Adv. 2021 Jan;7(1)