Percc1 MGI Mouse Gene Detail - MGI:5621540 - proline and glutamate rich with coiled coil 1

Percc1 Gene Detail

Symbol

Percc1
Name

proline and glutamate rich with coiled coil 1
Synonyms

Gm38655

Feature Type

protein coding gene
IDs

MGI:5621540
NCBI Gene: 102643076
Alliance

gene page

Sequence Map

Chr17:25391871-25394445 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, Syntenic
Mapping Data

1 experiment

SNPs within 2kb

131 from dbSNP Build 142
Strain Annotations

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_5621540	protein coding gene	Chr17:25390128-25399792 (-)
129S1/SvImJ	no annotation
A/J	no annotation
AKR/J	no annotation
BALB/cJ	no annotation
C3H/HeJ	no annotation
C57BL/6NJ	no annotation
CAROLI/EiJ	no annotation
CAST/EiJ	no annotation
CBA/J	no annotation
DBA/2J	no annotation
FVB/NJ	no annotation
LP/J	no annotation
NOD/ShiLtJ	no annotation
NZO/HlLtJ	no annotation
PWK/PhJ	no annotation
SPRET/EiJ	no annotation
WSB/EiJ	no annotation

Human Ortholog

PERCC1, proline and glutamate rich with coiled coil 1

Vertebrate Orthologs

1

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PERCC1, proline and glutamate rich with coiled coil 1
Synonyms

DIAR11, gs104, ICR
Links

HGNC:52293

NCBI Gene ID: 105371045

UniProt: A0A1W2PR82
Chr Location

chr16:1431078-1434441 (+) GRCh38

MGI Vertebrate Homology

Percc1 stringent orthology
1 human;1 mouse
HCOP

vertebrate homology predictions: PERCC1
Gene Tree

Percc1

Diseases

1 with human PERCC1 associations

				Human Disease	Mouse Models
				congenital diarrhea IDs congenital diarrhea DOID:0060774 OMIM:PS214700

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

6 phenotypes from 2 alleles in 2 genetic backgrounds
1 phenotype reference

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

2
Endonuclease-mediated

1
Targeted

1
Find Mice (IMSR)

1 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit reduced weight, premature death, abnormal intestinal and fecal microbiome composition and reduced gastrin-expressing cells.

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All GO Annotations

2
GO References

1

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

709
Tissues

3
cDNA Data

1
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Expression Atlas
Other Vertebrate Links

Xenbase XB940087

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All Sequences

11
RefSeq

4
UniProt

1
CCDS

CCDS89018.1

Ensembl

ENSMUSG00000114245 (Evidence)
NCBI Gene

102643076

			Length	Strain/Species	Flank
genomic	ENSMUSG00000114245	Ensembl Gene Model \| MGI Sequence Detail	2575	C57BL/6J	± kb
transcript	ENSMUST00000224277	Ensembl \| MGI Sequence Detail	906	Not Applicable
polypeptide	ENSMUSP00000153456	Ensembl \| MGI Sequence Detail	273	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000059672 protein PERCC1

(term hierarchy)

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All nucleic 2

cDNA 1

Other 1

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MGI:6384663

Summaries

All 7

Developmental Gene Expression 1

Gene Ontology 1

Phenotypes 1
Earliest

J:279976 Oz-Levi D, et al., Noncoding deletions reveal a gene that is critical for intestinal function. Nature. 2019 Jul;571(7763):107-111

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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