Mirc40 Complex/Cluster/Region Detail

Summary

• Symbol
  Mirc40
• Name
  micro RNA cluster 40, including Mir96 through Mir183

• Feature Type
  complex/cluster/region
• IDs
  MGI:5645902
• Cluster Members
  Mir96, Mir183 (2 members)

Location &
Maps

• Sequence Map
  Chr6:30169445-30169736 bp

  From MGI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 6, Syntenic

Strain
Comparison

• SNPs within 2kb
  79 from dbSNP Build 142

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  8 phenotypes from 1 allele in 1 genetic background
  5 phenotype references
  

• All Mutations and Alleles
  2
• Targeted
  2
• Find Mice (IMSR)
  1 strains or lines available

Mice homozygous for a knock-out allele exhibit short cone cell outer segments, impaired cone cell nuclear polarization, impaired photopic and scotopic function, thin retinal outer nuclear layer, microglia activation and thinned retinal blood vessels.

References

• Summaries
  All 6

  Phenotypes 5
• Earliest
  J:244554 Xiang L, et al., miR-183/96 plays a pivotal regulatory role in mouse photoreceptor maturation and maintenance. Proc Natl Acad Sci U S A. 2017 Jun 13;114(24):6376-6381
• Latest
  J:309554 Krohs C, et al., Loss of miR-183/96 Alters Synaptic Strength via Presynaptic and Postsynaptic Mechanisms at a Central Synapse. J Neurosci. 2021 Aug 11;41(32):6796-6811

Mirc40 Cluster contains:

More Data for these features

Member	Feature Type	Location
Mir96, microRNA 96	miRNA gene	Chr6:30169445-30169550 (-)
Mir183, microRNA 183	miRNA gene	Chr6:30169667-30169736 (-)