Dbnl MGI Mouse Gene Detail - MGI:700006

Symbol

Dbnl
Name

drebrin-like
Synonyms

ABP1, mAbp1, SH3P7

Feature Type

protein coding gene
IDs

MGI:700006
NCBI Gene: 13169
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr11:5738488-5750962 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 3.87 cM
Mapping Data

2 experiments

SNPs within 2kb

399 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_700006	protein coding gene	Chr11:5730233-5750980 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018006	protein coding gene	Chr11:2870072-2883897 (+)
A/J	MGP_AJ_G0017979	protein coding gene	Chr11:2757800-2770081 (+)
AKR/J	MGP_AKRJ_G0017943	protein coding gene	Chr11:2898916-2911135 (+)
BALB/cJ	MGP_BALBcJ_G0017947	protein coding gene	Chr11:2748676-2761312 (+)
C3H/HeJ	MGP_C3HHeJ_G0017760	protein coding gene	Chr11:2775204-2790218 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018399	protein coding gene	Chr11:2949073-2961567 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016057	protein coding gene	Chr11:2641683-2654288 (+)
CAST/EiJ	MGP_CASTEiJ_G0017322	protein coding gene	Chr11:2739440-2753875 (+)
CBA/J	MGP_CBAJ_G0017735	protein coding gene	Chr11:3296687-3309131 (+)
DBA/2J	MGP_DBA2J_G0017845	protein coding gene	Chr11:2663776-2676438 (+)
FVB/NJ	MGP_FVBNJ_G0017837	protein coding gene	Chr11:2692781-2705137 (+)
LP/J	MGP_LPJ_G0017916	protein coding gene	Chr11:2950548-2962814 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017863	protein coding gene	Chr11:2914825-2927065 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018439	protein coding gene	Chr11:2903340-2916664 (+)
PWK/PhJ	MGP_PWKPhJ_G0017102	protein coding gene	Chr11:2687279-2699867 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016899	protein coding gene	Chr11:2870016-2882618 (+)
WSB/EiJ	MGP_WSBEiJ_G0017376	protein coding gene	Chr11:2749705-2761977 (+)

Human Ortholog

DBNL, drebrin like

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DBNL, drebrin like
Synonyms

ABP1, HIP-55, HIP55, SH3P7
Links

HGNC:2696

NCBI Gene ID: 28988

neXtProt AC: NX_Q9UJU6

UniProt: Q9UJU6
Chr Location

7p13; chr7:44044640-44069456 (+) GRCh38

MGI Vertebrate Homology

Dbnl stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: DBNL
Gene Tree

Dbnl

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Phenotype Summary

51 phenotypes from 3 alleles in 3 genetic backgrounds
17 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

37
Endonuclease-mediated

2
Gene trapped

31
Targeted

4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

27 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Targeted mutation causes abnormal structure and function in organs including the spleen, heart and lungs. Vesicle transport is impaired in the brain and neurological impairment is observed.

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All GO Annotations

55
GO References

12

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

774
Tissues

48
cDNA Data

150
Literature Summary

8

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase dbnl

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All Sequences

80
RefSeq

8
UniProt

1
CCDS

CCDS24403.1, CCDS48746.1, CCDS48747.1

Ensembl

ENSMUSG00000020476 (Evidence)
NCBI Gene

13169

			Length	Strain/Species	Flank
genomic	ENSMUSG00000020476	Ensembl Gene Model \| MGI Sequence Detail	12475	C57BL/6J	± kb
transcript	ENSMUST00000020769	Ensembl \| MGI Sequence Detail	1638	Not Applicable
polypeptide	ENSMUSP00000020769	Ensembl \| MGI Sequence Detail	436	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000006297 drebrin-like protein

(term hierarchy)
InterPro Domains

IPR002108 Actin-depolymerising factor homology domain

IPR029006 ADF-H/Gelsolin-like domain superfamily

IPR035717 Drebrin-like protein, SH3 domain

IPR001452 SH3 domain

IPR036028 SH3-like domain superfamily
GlyGen

Q62418 4 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (2 sites)

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All nucleic 150

cDNA 150

Microarray probesets 3

Summaries

All 57

Developmental Gene Expression 8

Gene Ontology 12

Phenotypes 17
Earliest

J:35786 Sparks AB, et al., Cloning of ligand targets: systematic isolation of SH3 domain-containing proteins. Nat Biotechnol. 1996 Jun;14(6):741-4
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Dbnl:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr100198	Chr11:5738480-5738560 (+)	32 bp
Tssr100199	Chr11:5743709-5743726 (+)	5,230 bp
Tssr100200	Chr11:5747511-5747526 (+)	9,031 bp
Tssr100201	Chr11:5747540-5747554 (+)	9,059 bp
Tssr100202	Chr11:5747987-5748005 (+)	9,508 bp
Tssr100203	Chr11:5749284-5749305 (+)	10,807 bp
Tssr100204	Chr11:5750147-5750184 (+)	11,678 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24