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Ostf1 Gene Detail
Summary
  • Symbol
    Ostf1
  • Name
    osteoclast stimulating factor 1
  • Synonyms
    C78236, Sh3d3, SH3P2
  • Feature Type
    protein coding gene
  • IDs
    MGI:700012
    NCBI Gene: 20409
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:18557728-18609177 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 13.17 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2113 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_700012
 protein coding gene Chr19:18493501-18609187 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024966
 protein coding gene Chr19:16449286-16506008 (-)
A/J MGP_AJ_G0024943
 protein coding gene Chr19:15528423-15580542 (-)
AKR/J MGP_AKRJ_G0024913
 protein coding gene Chr19:16144905-16199664 (-)
BALB/cJ MGP_BALBcJ_G0024942
 protein coding gene Chr19:15558722-15611234 (-)
C3H/HeJ MGP_C3HHeJ_G0024700
 protein coding gene Chr19:16085902-16137572 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025384
 protein coding gene Chr19:17035924-17092204 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022803
 protein coding gene Chr19:15897860-15951993 (-)
CAST/EiJ MGP_CASTEiJ_G0024168
 protein coding gene Chr19:15717014-15779126 (-)
CBA/J MGP_CBAJ_G0024678
 protein coding gene Chr19:17652102-17711792 (-)
DBA/2J MGP_DBA2J_G0024810
 protein coding gene Chr19:15556114-15608396 (-)
FVB/NJ MGP_FVBNJ_G0024771
 protein coding gene Chr19:15475075-15526812 (-)
LP/J MGP_LPJ_G0024894
 protein coding gene Chr19:16423423-16479545 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024798
 protein coding gene Chr19:17535376-17590965 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025439
 protein coding gene Chr19:16080391-16132405 (-)
PWK/PhJ MGP_PWKPhJ_G0023917
 protein coding gene Chr19:15094545-15148143 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023722
 protein coding gene Chr19:15365106-15419089 (-)
WSB/EiJ MGP_WSBEiJ_G0024236
 protein coding gene Chr19:16127871-16182308 (-)



Homology
more
  • Human Ortholog
    OSTF1, osteoclast stimulating factor 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    OSTF1, osteoclast stimulating factor 1
  • Synonyms
    bA235O14.1, OSF, SH3P2
  • Links
    NCBI Gene ID: 26578
    neXtProt AC: NX_Q92882
    UniProt: Q92882

  • Chr Location
    9q21.13; chr9:75088514-75147265 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 2 alleles in 2 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous knockout results in increased trabecular number and bone density in the femur and tibia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    3
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    874
  • Tissues
    129
  • cDNA Data
    92
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20409 NCBI Gene Model | MGI Sequence Detail 51450 C57BL/6J ±  kb
    transcript NM_017375 RefSeq | MGI Sequence Detail 1714 ZRU/MplStud  
    polypeptide Q62422 UniProt | EBI | MGI Sequence Detail 215 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 92
      cDNA 92

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2147784
    References
    more
    • Summaries
      All 45
      Developmental Gene Expression 3
      Gene Ontology 3
      Phenotypes 13
    • Earliest
      J:35786 Sparks AB, et al., Cloning of ligand targets: systematic isolation of SH3 domain-containing proteins. Nat Biotechnol. 1996 Jun;14(6):741-4
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory