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Acadm Gene Detail
Summary
  • Symbol
    Acadm
  • Name
    acyl-Coenzyme A dehydrogenase, medium chain
  • Synonyms
    MCAD
  • Feature Type
    protein coding gene
  • IDs
    MGI:87867
    NCBI Gene: 11364
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:153627994-153650269 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 78.77 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    755 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    4
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_87867
 protein coding gene Chr3:153627990-153650280 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028000
 protein coding gene Chr3:157891838-157916477 (-)
A/J MGP_AJ_G0027959
 protein coding gene Chr3:152139617-152161553 (-)
AKR/J MGP_AKRJ_G0027925
 protein coding gene Chr3:156214536-156236474 (-)
BALB/cJ MGP_BALBcJ_G0027971
 protein coding gene Chr3:151949178-151972632 (-)
C3H/HeJ MGP_C3HHeJ_G0027701
 protein coding gene Chr3:156581373-156606124 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028414
 protein coding gene Chr3:163034862-163058266 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025752
 protein coding gene Chr3:146913060-146935566 (-)
CAST/EiJ MGP_CASTEiJ_G0027154
 protein coding gene Chr3:156696255-156717935 (-)
CBA/J MGP_CBAJ_G0027676
 protein coding gene Chr3:168914700-168940636 (-)
DBA/2J MGP_DBA2J_G0027816
 protein coding gene Chr3:151221298-151243951 (-)
FVB/NJ MGP_FVBNJ_G0027783
 protein coding gene Chr3:148601180-148623244 (-)
LP/J MGP_LPJ_G0027927
 protein coding gene Chr3:159223921-159245804 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027816
 protein coding gene Chr3:177381760-177405674 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028473
 protein coding gene Chr3:155856925-155883780 (-)
PWK/PhJ MGP_PWKPhJ_G0026877
 protein coding gene Chr3:151137427-151160201 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026705
 protein coding gene Chr3:154015331-154030758 (-)
WSB/EiJ MGP_WSBEiJ_G0027234
 protein coding gene Chr3:156840243-156865256 (-)



Homology
more
  • Human Ortholog
    ACADM, acyl-CoA dehydrogenase medium chain
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ACADM, acyl-CoA dehydrogenase medium chain
  • Synonyms
    ACAD1, MCAD, MCADH
  • Links
    NCBI Gene ID: 34
    neXtProt AC: NX_P11310
    UniProt: P11310

  • Chr Location
    1p31.1; chr1:75724431-75787575 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Acadm mouse models; 1 with human ACADM associations

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 2 alleles in 2 genetic backgrounds
    1 images
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele display a high degree of postnatal lethality, develop an organic aciduria, fatty liver and an unexpected diffuse cardiomyopathy with multifocal myocyte degeneration and necrosis, and show severe cold intolerance with prior fasting.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    52
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1069
  • Tissues
    230
  • cDNA Data
    302
  • Literature Summary
    30
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000062908 Ensembl Gene Model | MGI Sequence Detail 22276 C57BL/6J ±  kb
    transcript ENSMUST00000072697 Ensembl | MGI Sequence Detail 2047 Not Applicable  
    polypeptide ENSMUSP00000072483 Ensembl | MGI Sequence Detail 421 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • Protein Ontology
      PR:000003601 medium-chain specific acyl-CoA dehydrogenase, mitochondrial
      (term hierarchy)
    • EC
      1.3.8.7
    • InterPro Domains
      IPR050741 Acyl-CoA dehydrogenase
      IPR006089 Acyl-CoA dehydrogenase, conserved site
      IPR036250 Acyl-CoA dehydrogenase-like, C-terminal
      IPR009075 Acyl-CoA dehydrogenase/oxidase, C-terminal
      IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal
      IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain superfamily
      IPR037069 Acyl-CoA dehydrogenase/oxidase, N-terminal domain superfamily
      IPR006091 Acyl-CoA oxidase/dehydrogenase, middle domain
      IPR046373 Acyl-CoA oxidase/dehydrogenase, middle domain superfamily
      IPR034180 Medium-chain specific acyl-CoA dehydrogenase
    • GlyGen
      P45952 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 317
      Genomic 3
      cDNA 307
      Primer pair 6
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-1024, MGI:2139874
    References
    more
    • Summaries
      All 90
      Developmental Gene Expression 30
      Diseases 1
      Gene Ontology 12
      Phenotypes 17
    • Earliest
      J:14629 Kelly DP, et al., Nucleotide sequence of medium-chain acyl-CoA dehydrogenase mRNA and its expression in enzyme-deficient human tissue. Proc Natl Acad Sci U S A. 1987 Jun;84(12):4068-72
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory