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Acp1 Gene Detail
Summary
  • Symbol
    Acp1
  • Name
    acid phosphatase 1, soluble
  • Synonyms
    4632432E04Rik, Acp-1, Lmptp, LMW-PTP
  • Feature Type
    protein coding gene
  • IDs
    MGI:87881
    NCBI Gene: 11431
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:30943325-30961588 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 13.00 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    503 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_87881
 protein coding gene Chr12:30943325-30961616 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019654
 protein coding gene Chr12:28811890-28834004 (-)
A/J MGP_AJ_G0019621
 protein coding gene Chr12:28005698-28024601 (-)
AKR/J MGP_AKRJ_G0019592
 protein coding gene Chr12:28908278-28927602 (-)
BALB/cJ MGP_BALBcJ_G0019598
 protein coding gene Chr12:28249524-28269983 (-)
C3H/HeJ MGP_C3HHeJ_G0019402
 protein coding gene Chr12:28772175-28793507 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020045
 protein coding gene Chr12:29707099-29726968 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017670
 protein coding gene Chr12:27326929-27345325 (-)
CAST/EiJ MGP_CASTEiJ_G0018957
 protein coding gene Chr12:23773436-23791541 (-)
CBA/J MGP_CBAJ_G0019373
 protein coding gene Chr12:30678157-30701748 (-)
DBA/2J MGP_DBA2J_G0019487
 protein coding gene Chr12:27840666-27865343 (-)
FVB/NJ MGP_FVBNJ_G0019478
 protein coding gene Chr12:27641907-27659055 (-)
LP/J MGP_LPJ_G0019557
 protein coding gene Chr12:28904959-28932544 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019513
 protein coding gene Chr12:30307243-30325771 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020085
 protein coding gene Chr12:28428377-28447607 (-)
PWK/PhJ MGP_PWKPhJ_G0018724
 protein coding gene Chr12:22579150-22598379 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018512
 protein coding gene Chr12:23050138-23068712 (-)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    ACP1, acid phosphatase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ACP1, acid phosphatase 1
  • Synonyms
    HAAP, LMW-PTP, LMWPTP
  • Links
    NCBI Gene ID: 52
    neXtProt AC: NX_P24666
    UniProt: P24666

  • Chr Location
    2p25.3; chr2:264140-278283 (+)  GRCh38
Human Diseases
more
  • Diseases
    8 with human ACP1 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele show an increased mean serum IL-6 response to LPS challenge. Male homozygotes are smaller than controls whereas female homozygotes show an increased mean skin fibroblast proliferation rate. Males homozygous for a different null allele show decreased response of heart to induced stress.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    18
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1020
  • Tissues
    141
  • cDNA Data
    21
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000044573 Ensembl Gene Model | MGI Sequence Detail 18264 C57BL/6J ±  kb
    transcript ENSMUST00000062740 Ensembl | MGI Sequence Detail 3066 Not Applicable  
    polypeptide ENSMUSP00000106509 Ensembl | MGI Sequence Detail 158 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000003646 low molecular weight phosphotyrosine protein phosphatase
      (term hierarchy)
    • PDB
      2P4U, 5JNU
    • EC
      3.1.3.2, 3.1.3.48
    • InterPro Domains
      IPR050438 Low Molecular Weight Phosphotyrosine Protein Phosphatase
      IPR023485 Phosphotyrosine protein phosphatase I
      IPR036196 Phosphotyrosine protein phosphatase I superfamily
      IPR017867 Protein-tyrosine phosphatase, low molecular weight
      IPR002115 Protein-tyrosine phosphatase, low molecular weight, mammalian
    Molecular
    Reagents
    less
    • All nucleic 22
      cDNA 21
      Primer pair 1

      Microarray probesets 18
    Other
    Accession IDs
    less
    MGD-MRK-1048, MGD-MRK-1050, MGI:1914786, MGI:2144813
    References
    more
    • Summaries
      All 47
      Developmental Gene Expression 4
      Gene Ontology 13
      Phenotypes 10
    • Earliest
      J:5872 Francke U, et al., Gene mapping in Mus musculus by interspecific cell hybridization: assignment of the genes for tripeptidase-1 to chromosome 10, dipeptidase-2 to chromosome 18, acid phosphatase-1 to chromosome 12, and adenylate kinase-1 to chromosome 2. Cytogenet Cell Genet. 1977;19(2-3):57-84
    • Latest
      J:330782 Jensen-Cody S, et al., Loss of low-molecular-weight protein tyrosine phosphatase shows limited improvement in glucose tolerance but causes mild cardiac hypertrophy in mice. Am J Physiol Endocrinol Metab. 2022 Jun 1;322(6):E517-E527
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory