Acp2 MGI Mouse Gene Detail - MGI:87882 - acid phosphatase 2, lysosomal

Symbol

Acp2
Name

acid phosphatase 2, lysosomal
Synonyms

Acp-2, LAP

Feature Type

protein coding gene
IDs

MGI:87882
NCBI Gene: 11432
Alliance

gene page
Transcription Start Sites

14 TSS

Sequence Map

Chr2:91033230-91044443 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 50.54 cM
Mapping Data

5 experiments

SNPs within 2kb

206 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_87882	protein coding gene	Chr2:91033157-91044443 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0026145	protein coding gene	Chr2:92511981-92525056 (+)
A/J	MGP_AJ_G0026106	protein coding gene	Chr2:88813796-88824998 (+)
AKR/J	MGP_AKRJ_G0026087	protein coding gene	Chr2:91268806-91279982 (+)
BALB/cJ	MGP_BALBcJ_G0026115	protein coding gene	Chr2:88993525-89004681 (+)
C3H/HeJ	MGP_C3HHeJ_G0025866	protein coding gene	Chr2:91545909-91557858 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0026566	protein coding gene	Chr2:95778700-95789852 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023956	protein coding gene	Chr2:85323633-85334927 (+)
CAST/EiJ	MGP_CASTEiJ_G0025331	protein coding gene	Chr2:92073274-92086343 (+)
CBA/J	MGP_CBAJ_G0025844	protein coding gene	Chr2:99025308-99036448 (+)
DBA/2J	MGP_DBA2J_G0025980	protein coding gene	Chr2:88414451-88425601 (+)
FVB/NJ	MGP_FVBNJ_G0025943	protein coding gene	Chr2:87523206-87535473 (+)
LP/J	MGP_LPJ_G0026084	protein coding gene	Chr2:92725168-92738856 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025969	protein coding gene	Chr2:102065450-102077616 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026620	protein coding gene	Chr2:91337584-91350282 (+)
PWK/PhJ	MGP_PWKPhJ_G0025066	protein coding gene	Chr2:88142809-88154281 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0024867	protein coding gene	Chr2:90908775-90919844 (+)
WSB/EiJ	MGP_WSBEiJ_G0025398	protein coding gene	Chr2:91933595-91947531 (+)

Human Ortholog

ACP2, acid phosphatase 2, lysosomal

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ACP2, acid phosphatase 2, lysosomal
Synonyms

LAP
Links

HGNC:123

NCBI Gene ID: 53

neXtProt AC: NX_P11117

UniProt: P11117
Chr Location

11p11.2-p11.11; chr11:47239302-47248906 (-) GRCh38

MGI Vertebrate Homology

Acp2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ACP2
Gene Tree

Acp2

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Phenotype Summary

44 phenotypes from 3 alleles in 3 genetic backgrounds
3 images
29 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

15
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

3
Radiation induced

1
Spontaneous

1
Targeted

5
Transgenic

1
Genomic Mutations

4 involving Acp2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

27 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mutation of this gene result in skeletal defects and a small percentage of mutant animals exhibit tonic-clonic seizures. Mice with a missense mutation (Gly244Glu) are growth retarded and exhibit a disrupted cerebellum cytoarchitecture, an abnormal hair shaft, and skin malformations.

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All GO Annotations

18
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

994
Tissues

186
cDNA Data

91
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase acp2

ZFIN acp2

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All Sequences

63
RefSeq

7
UniProt

6
CCDS

CCDS16427.1, CCDS89516.1

Ensembl

ENSMUSG00000002103 (Evidence)
NCBI Gene

11432

			Length	Strain/Species	Flank
genomic	ENSMUSG00000002103	Ensembl Gene Model \| MGI Sequence Detail	11214	C57BL/6J	± kb
transcript	ENSMUST00000238832	Ensembl \| MGI Sequence Detail	4656	Not Applicable
polypeptide	ENSMUSP00000159089	Ensembl \| MGI Sequence Detail	434	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000003647 lysosomal acid phosphatase

(term hierarchy)
EC

3.1.3.2
InterPro Domains

IPR050645 Histidine Acid Phosphatase

IPR033379 Histidine acid phosphatase active site

IPR029033 Histidine phosphatase superfamily

IPR000560 Histidine phosphatase superfamily, clade-2
GlyGen

P24638 10 sites, 12 N-linked glycans (4 sites)

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All nucleic 93

Genomic 1

cDNA 91

Primer pair 1

Microarray probesets 8

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MGD-MRK-1049, MGD-MRK-1051

Summaries

All 69

Developmental Gene Expression 5

Gene Ontology 11

Phenotypes 29
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Acp2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr18869	Chr2:91033137-91033143 (+)	-90 bp
Tssr18870	Chr2:91033248-91033279 (+)	34 bp
Tssr18871	Chr2:91033603-91033612 (+)	378 bp
Tssr18872	Chr2:91036157-91036174 (+)	2,936 bp
Tssr18873	Chr2:91036370-91036391 (+)	3,151 bp
Tssr18874	Chr2:91036802-91036820 (+)	3,581 bp
Tssr18875	Chr2:91036854-91036871 (+)	3,633 bp
Tssr18876	Chr2:91036878-91036902 (+)	3,660 bp
Tssr18877	Chr2:91037124-91037165 (+)	3,915 bp
Tssr18878	Chr2:91038155-91038170 (+)	4,933 bp
Tssr18879	Chr2:91039214-91039229 (+)	5,992 bp
Tssr18880	Chr2:91041116-91041141 (+)	7,899 bp
Tssr18881	Chr2:91041164-91041189 (+)	7,947 bp
Tssr18882	Chr2:91041224-91041250 (+)	8,007 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24