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Chrna3 Gene Detail
Summary
  • Symbol
    Chrna3
  • Name
    cholinergic receptor, nicotinic, alpha polypeptide 3
  • Synonyms
    (a)3, A730007P14Rik, Acra-3, Acra3, alpha 3, neuronal nicotinic acetylcholine receptor, alpha 3 subunit
  • Feature Type
    protein coding gene
  • IDs
    MGI:87887
    NCBI Gene: 110834
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:54917401-54933846 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 29.84 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    511 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_87887
 protein coding gene Chr9:54917395-54933846 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034836
 protein coding gene Chr9:54090744-54106017 (-)
A/J MGP_AJ_G0034817
 protein coding gene Chr9:52350961-52366220 (-)
AKR/J MGP_AKRJ_G0034746
 protein coding gene Chr9:53549109-53563592 (-)
BALB/cJ MGP_BALBcJ_G0034809
 protein coding gene Chr9:52131380-52145838 (-)
C3H/HeJ MGP_C3HHeJ_G0034519
 protein coding gene Chr9:54009128-54024984 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035328
 protein coding gene Chr9:55591238-55606799 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032240
 protein coding gene Chr9:51765819-51780428 (-)
CAST/EiJ MGP_CASTEiJ_G0033841
 protein coding gene Chr9:54031727-54048767 (-)
CBA/J MGP_CBAJ_G0034490
 protein coding gene Chr9:57530196-57546418 (-)
DBA/2J MGP_DBA2J_G0034649
 protein coding gene Chr9:52244118-52262740 (-)
FVB/NJ MGP_FVBNJ_G0034591
 protein coding gene Chr9:51448849-51464002 (-)
LP/J MGP_LPJ_G0034732
 protein coding gene Chr9:54394334-54411879 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034634
 protein coding gene Chr9:59045061-59060402 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035350
 protein coding gene Chr9:53566641-53581837 (-)
PWK/PhJ MGP_PWKPhJ_G0033545
 protein coding gene Chr9:52226844-52243156 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033380
 protein coding gene Chr9:53823964-53845487 (-)
WSB/EiJ MGP_WSBEiJ_G0033953
 protein coding gene Chr9:53528592-53545035 (-)



Homology
more
  • Human Ortholog
    CHRNA3, cholinergic receptor nicotinic alpha 3 subunit
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CHRNA3, cholinergic receptor nicotinic alpha 3 subunit
  • Synonyms
    BAIPRCK, LNCR2, NACHRA3, PAOD2
  • Links
    NCBI Gene ID: 1136
    neXtProt AC: NX_P32297
    UniProt: P32297

  • Chr Location
    15q25.1; chr15:78593052-78621295 (-)  GRCh38
Human Diseases
more
  • Diseases
    10 with human CHRNA3 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    30 phenotypes from 2 alleles in 5 genetic backgrounds
    1 phenotype from multigenic genotypes
    1 images
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation show high postnatal and postweaning mortality. Mutants show reduced bladder contractility resulting in enlarged bladder, infections and urinary stones. Eyes are small, with dilated ocular pupils.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    62
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    920
  • Tissues
    79
  • cDNA Data
    19
  • Literature Summary
    14
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 110834 NCBI Gene Model | MGI Sequence Detail 16446 C57BL/6J ±  kb
    transcript NM_145129 RefSeq | MGI Sequence Detail 4352 C57BL/6  
    polypeptide Q8R4G9 UniProt | EBI | MGI Sequence Detail 499 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000005456 neuronal acetylcholine receptor subunit alpha-3
      (term hierarchy)
    • InterPro Domains
      IPR038050 Neuronal acetylcholine receptor
      IPR006201 Neurotransmitter-gated ion-channel
      IPR018000 Neurotransmitter-gated ion-channel, conserved site
      IPR006202 Neurotransmitter-gated ion-channel ligand-binding domain
      IPR036734 Neurotransmitter-gated ion-channel ligand-binding domain superfamily
      IPR006029 Neurotransmitter-gated ion-channel transmembrane domain
      IPR036719 Neurotransmitter-gated ion-channel transmembrane domain superfamily
      IPR002394 Nicotinic acetylcholine receptor
    • GlyGen
      Q8R4G9 2 sites
    Molecular
    Reagents
    less
    • All nucleic 26
      cDNA 22
      Primer pair 3
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-1056, MGD-MRK-1060, MGI:2445169
    References
    more
    • Summaries
      All 81
      Developmental Gene Expression 14
      Gene Ontology 15
      Phenotypes 19
    • Earliest
      J:10489 Bessis A, et al., Chromosomal localization of the mouse genes coding for alpha 2, alpha 3, alpha 4 and beta 2 subunits of neuronal nicotinic acetylcholine receptor. FEBS Lett. 1990 May 7;264(1):48-52
    • Latest
      J:350122 Tsuzuki A, et al., Abundant extrasynaptic expression of alpha3beta4-containing nicotinic acetylcholine receptors in the medial habenula-interpeduncular nucleus pathway in mice. Sci Rep. 2024 Jun 20;14(1):14193
    Contributing Projects:
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    12/10/2024
    MGI 6.24     		The Jackson Laboratory