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Chrna4
Gene Detail
Symbol

Name
ID
Chrna4
cholinergic receptor, nicotinic, alpha polypeptide 4
MGI:87888
Synonyms
a4 nicotinic receptor, Acra4, Acra-4, alpha4 nAChR, alpha4-nAChR
Feature Type
protein coding gene
Genetic Map
Chromosome 2
103.54 cM
Detailed Genetic Map ± 1 cM


Mapping data(12)
Sequence Map
Chr2:181018380-181043546 bp, - strand
From VEGA annotation of GRCm38

  25167 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:592  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: CHRNA4
Gene Tree: Chrna4

Human
homologs
CHRNA4, cholinergic receptor, nicotinic, alpha 4 (neuronal)
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 1137
neXtProt AC: NX_P43681

Human Synonyms: BFNC, EBN, EBN1, NACHR, NACHRA4, NACRA4

Human Chr (Location): 20q13.33; chr20:63343310-63361396 (-)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human CHRNA4

Mutations,
alleles, and
phenotypes
All mutations/alleles(17) : Gene trapped(1) Spontaneous(1) Targeted(15)
Genomic Mutations involving Chrna4 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Nullizygous mice may show reduced chemically-elicited analgesia, susceptibility to seizures, increased anxiety, and altered behavioral responses to nicotine or a new environment. Homozygotes for any of several knock-in alleles exhibit altered nervous system physiology and/or sensitivity to nicotine.
 
Interactions
Chrna4 interacts with 250 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (11 records)
Data Summary: Results (214)    Tissues (122)    Images (23)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 189
Northern blot 8
RT-PCR 17
cDNA source data(48)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase chrna4 ; ZFIN chrna4b    NEW 
Molecular
reagents
All nucleic(54) cDNA(51) Primer pair(2) Other(1)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000016395 (Evidence)
Ensembl Gene Model ENSMUSG00000027577 (Evidence)
Entrez Gene 11438 (Evidence)
UniGene 252369
DFCI TC1579781
DoTS DT.60102954
NIA Mouse Gene Index U023772
Consensus CDS Project CCDS17192.1
International Mouse Phenotyping Consortium Status Chrna4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016395 VEGA Gene Model | MGI Sequence Detail 25167 C57BL/6J ±  kb
transcript OTTMUST00000039489 VEGA | MGI Sequence Detail 2183 Not Applicable 
polypeptide OTTMUSP00000017644 VEGA | MGI Sequence Detail 641 Not Applicable 

For the selected sequences
All sequences(44) RefSeq(4) UniProt(5)
Polymorphisms
RFLP(3) : SNPs within 2kb(162 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006201 Neurotransmitter-gated ion-channel
InterPro IPR018000 Neurotransmitter-gated ion-channel, conserved site
InterPro IPR006202 Neurotransmitter-gated ion-channel ligand-binding
InterPro IPR006029 Neurotransmitter-gated ion-channel transmembrane domain
InterPro IPR027361 Nicotinic acetylcholine-gated receptor, transmembrane domain
InterPro IPR002394 Nicotinic acetylcholine receptor
Protein Ontology PR:000005457 neuronal acetylcholine receptor subunit alpha-4
References
(Earliest) J:10489 Bessis A, et al., Chromosomal localization of the mouse genes coding for alpha 2, alpha 3, alpha 4 and beta 2 subunits of neuronal nicotinic acetylcholine receptor. FEBS Lett. 1990 May 7;264(1):48-52
(Latest) J:212011 Garcao P, et al., Subsynaptic localization of nicotinic acetylcholine receptor subunits: a comparative study in the mouse and rat striatum. Neurosci Lett. 2014 Apr 30;566:106-10
All references(100)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-1057, MGD-MRK-1061

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory