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Chrna4
Gene Detail
Symbol

Name
ID
Chrna4
cholinergic receptor, nicotinic, alpha polypeptide 4
MGI:87888
Synonyms
a4 nicotinic receptor, Acra4, Acra-4, alpha4 nAChR, alpha4-nAChR
Feature Type
protein coding gene
Genetic Map
Chromosome 2
103.54 cM
Detailed Genetic Map ± 1 cM


Mapping data(12)
Sequence Map
Chr2:181018380-181043546 bp, - strand
From VEGA annotation of GRCm38

  25167 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:592  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Gene Tree: Chrna4

Human
homologs
Human Homolog CHRNA4, cholinergic receptor, nicotinic, alpha 4 (neuronal)
NCBI Gene ID 1137
neXtProt AC  NX_P43681
Human Synonyms  BFNC, EBN, EBN1, NACHR, NACHRA4, NACRA4
Human Chr (Location)  20q13.33; chr20:63343310-63361396 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human CHRNA4
Mutations,
alleles, and
phenotypes
All mutations/alleles(17) : Gene trapped(1) Spontaneous(1) Targeted(15)
Genomic Mutations involving Chrna4 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Nullizygous mice may show reduced chemically-elicited analgesia, susceptibility to seizures, increased anxiety, and altered behavioral responses to nicotine or a new environment. Homozygotes for any of several knock-in alleles exhibit altered nervous system physiology and/or sensitivity to nicotine.
 
Interactions
Chrna4 interacts with 251 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (11 records)
Data Summary: Results (214)    Tissues (122)    Images (23)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 189
Northern blot 8
RT-PCR 17
cDNA source data(48)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(54) cDNA(51) Primer pair(2) Other(1)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000016395 (Evidence)
Ensembl Gene ModelENSMUSG00000027577 (Evidence)
Entrez Gene11438 (Evidence)
UniGene252369
DFCITC1579781
DoTSDT.60102954
NIA Mouse Gene IndexU023772
Consensus CDS ProjectCCDS17192.1
International Mouse Knockout Project StatusChrna4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016395 VEGA Gene Model | MGI Sequence Detail 25167 C57BL/6J ±  kb
transcript OTTMUST00000039489 VEGA | MGI Sequence Detail 2183 Not Applicable 
polypeptide OTTMUSP00000017644 VEGA | MGI Sequence Detail 641 Not Applicable 

For the selected sequences
All sequences(44) RefSeq(4) UniProt(5)
Polymorphisms
RFLP(3) : SNPs within 2kb(162 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006201 Neurotransmitter-gated ion-channel
InterPro IPR018000 Neurotransmitter-gated ion-channel, conserved site
InterPro IPR006202 Neurotransmitter-gated ion-channel ligand-binding
InterPro IPR006029 Neurotransmitter-gated ion-channel transmembrane domain
InterPro IPR027361 Nicotinic acetylcholine-gated receptor, transmembrane domain
InterPro IPR002394 Nicotinic acetylcholine receptor
Protein Ontology PR:000005457 neuronal acetylcholine receptor subunit alpha-4
References
(Earliest) J:10489 Bessis A, et al., Chromosomal localization of the mouse genes coding for alpha 2, alpha 3, alpha 4 and beta 2 subunits of neuronal nicotinic acetylcholine receptor. FEBS Lett. 1990 May 7;264(1):48-52
(Latest) J:204279 Chatterjee S, et al., The alpha5 subunit regulates the expression and function of alpha4*-containing neuronal nicotinic acetylcholine receptors in the ventral-tegmental area. PLoS One. 2013;8(7):e68300
All references(103)
Other
accession IDs
MGD-MRK-1057, MGD-MRK-1061

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory