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Chrnb2 Gene Detail
Summary
  • Symbol
    Chrnb2
  • Name
    cholinergic receptor nicotinic beta 2 subunit
  • Synonyms
    Acrb-2, Acrb2, [b]2-nAchR, C030030P04Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:87891
    NCBI Gene: 11444
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:89660755-89671939 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 39.19 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    261 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_87891
 protein coding gene Chr3:89653502-89671939 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027445
 protein coding gene Chr3:89979941-89998227 (-)
A/J MGP_AJ_G0027409
 protein coding gene Chr3:87001682-87020274 (-)
AKR/J MGP_AKRJ_G0027373
 protein coding gene Chr3:89116185-89134584 (-)
BALB/cJ MGP_BALBcJ_G0027418
 protein coding gene Chr3:86973321-86991816 (-)
C3H/HeJ MGP_C3HHeJ_G0027160
 protein coding gene Chr3:89308799-89328337 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027864
 protein coding gene Chr3:93366056-93386758 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025216
 protein coding gene Chr3:82496199-82508516 (-)
CAST/EiJ MGP_CASTEiJ_G0026606
 protein coding gene Chr3:89684541-89703969 (-)
CBA/J MGP_CBAJ_G0027134
 protein coding gene Chr3:96587532-96605973 (-)
DBA/2J MGP_DBA2J_G0027272
 protein coding gene Chr3:86380603-86399003 (-)
FVB/NJ MGP_FVBNJ_G0027240
 protein coding gene Chr3:84715632-84735049 (-)
LP/J MGP_LPJ_G0027381
 protein coding gene Chr3:91051910-91071805 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027260
 protein coding gene Chr3:102768500-102786938 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027923
 protein coding gene Chr3:88863854-88884426 (-)
PWK/PhJ MGP_PWKPhJ_G0026340
 protein coding gene Chr3:86263498-86283082 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026159
 protein coding gene Chr3:88051764-88070029 (-)
WSB/EiJ MGP_WSBEiJ_G0026688
 protein coding gene Chr3:89265367-89283883 (-)



Homology
more
  • Human Ortholog
    CHRNB2, cholinergic receptor nicotinic beta 2 subunit
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CHRNB2, cholinergic receptor nicotinic beta 2 subunit
  • Synonyms
    EFNL3, nAChRB2
  • Links
    NCBI Gene ID: 1141
    neXtProt AC: NX_P17787
    UniProt: P17787

  • Chr Location
    1q21.3; chr1:154567778-154580013 (+)  GRCh38
Human Diseases
more
  • Diseases
    3 with Chrnb2 mouse models; 2 with human CHRNB2 associations

Human Disease Mouse Models
      
IDs
 View 2 models
      
IDs
 View 1 model
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    52 phenotypes from 5 alleles in 10 genetic backgrounds
    25 phenotypes from multigenic genotypes
    153 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations have impaired responses to nicotine, but show improved passive avoidance behavior. With age, mutants show more neurodegeneration and alterations of the visual system, with decreased cortical visual acuity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    117
  • GO References
    44
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    970
  • Tissues
    210
  • cDNA Data
    59
  • Literature Summary
    15
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11444 NCBI Gene Model | MGI Sequence Detail 11185 C57BL/6J ±  kb
    transcript NM_009602 RefSeq | MGI Sequence Detail 5405 ZRU/MplStud  
    polypeptide Q9ERK7 UniProt | EBI | MGI Sequence Detail 501 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000005463 neuronal acetylcholine receptor subunit beta-2
      (term hierarchy)
    • InterPro Domains
      IPR038050 Neuronal acetylcholine receptor
      IPR006201 Neurotransmitter-gated ion-channel
      IPR018000 Neurotransmitter-gated ion-channel, conserved site
      IPR006202 Neurotransmitter-gated ion-channel ligand-binding domain
      IPR036734 Neurotransmitter-gated ion-channel ligand-binding domain superfamily
      IPR006029 Neurotransmitter-gated ion-channel transmembrane domain
      IPR036719 Neurotransmitter-gated ion-channel transmembrane domain superfamily
      IPR002394 Nicotinic acetylcholine receptor
    • GlyGen
      Q9ERK7 2 sites, 1 N-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 68
      cDNA 61
      Primer pair 5
      Other 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-1064, MGD-MRK-1066, MGI:2442758
    References
    more
    • Summaries
      All 231
      Developmental Gene Expression 15
      Diseases 4
      Gene Ontology 44
      Phenotypes 153
    • Earliest
      J:10489 Bessis A, et al., Chromosomal localization of the mouse genes coding for alpha 2, alpha 3, alpha 4 and beta 2 subunits of neuronal nicotinic acetylcholine receptor. FEBS Lett. 1990 May 7;264(1):48-52
    • Latest
      J:348087 Biswas S, et al., Glutamatergic neuronal activity regulates angiogenesis and blood-retinal barrier maturation via Norrin/beta-catenin signaling. Neuron. 2024 Apr 9;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory