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Chrng Gene Detail
Summary
  • Symbol
    Chrng
  • Name
    cholinergic receptor, nicotinic, gamma polypeptide
  • Synonyms
    Achr-3, Acrg
  • Feature Type
    protein coding gene
  • IDs
    MGI:87895
    NCBI Gene: 11449
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:87133533-87139365 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 44.07 cM
  • Mapping Data
    47 experiments
Strain
Comparison
more
  • SNPs within 2kb
    226 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    3
  • RFLP
    12
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_87895
 protein coding gene Chr1:87132379-87140416 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016260
 protein coding gene Chr1:88542109-88550175 (+)
A/J MGP_AJ_G0016241
 protein coding gene Chr1:85233762-85241791 (+)
AKR/J MGP_AKRJ_G0016202
 protein coding gene Chr1:87750600-87758637 (+)
BALB/cJ MGP_BALBcJ_G0016198
 protein coding gene Chr1:85356196-85364516 (+)
C3H/HeJ MGP_C3HHeJ_G0016026
 protein coding gene Chr1:88010077-88019140 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016654
 protein coding gene Chr1:91880402-91888439 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014376
 protein coding gene Chr1:79682720-79690756 (+)
CAST/EiJ MGP_CASTEiJ_G0015611
 protein coding gene Chr1:87213358-87221685 (+)
CBA/J MGP_CBAJ_G0016002
 protein coding gene Chr1:94750402-94758412 (+)
DBA/2J MGP_DBA2J_G0016105
 protein coding gene Chr1:84539615-84547865 (+)
FVB/NJ MGP_FVBNJ_G0016104
 protein coding gene Chr1:83598404-83606414 (+)
LP/J MGP_LPJ_G0016176
 protein coding gene Chr1:89605223-89614477 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016130
 protein coding gene Chr1:98042556-98051957 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016697
 protein coding gene Chr1:87851524-87862903 (+)
PWK/PhJ MGP_PWKPhJ_G0015398
 protein coding gene Chr1:83835063-83843636 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015178
 protein coding gene Chr1:86774906-86782936 (+)
WSB/EiJ MGP_WSBEiJ_G0015675
 protein coding gene Chr1:87523214-87531226 (+)



Homology
more
  • Human Ortholog
    CHRNG, cholinergic receptor nicotinic gamma subunit
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CHRNG, cholinergic receptor nicotinic gamma subunit
  • Synonyms
    ACHRG
  • Links
    NCBI Gene ID: 1146
    neXtProt AC: NX_P07510
    UniProt: P07510

  • Chr Location
    2q37.1; chr2:232539692-232548115 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human CHRNG associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    24 phenotypes from 3 alleles in 3 genetic backgrounds
    5 phenotypes from multigenic genotypes
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display perinatal and postnatal lethality, paradoxical breathing, abnormal skeletal muscle morphology, abnormal neuromuscular junction morphology and physiology, and are unable to suckle.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    31
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    900
  • Tissues
    62
  • cDNA Data
    27
  • Literature Summary
    21
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11449 NCBI Gene Model | MGI Sequence Detail 5833 C57BL/6J ±  kb
    transcript NM_009604 RefSeq | MGI Sequence Detail 1721 ZRU/MplStud  
    polypeptide P04760 UniProt | EBI | MGI Sequence Detail 519 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • Protein Ontology
      PR:000005468 acetylcholine receptor subunit gamma
      (term hierarchy)
    • InterPro Domains
      IPR038050 Neuronal acetylcholine receptor
      IPR006201 Neurotransmitter-gated ion-channel
      IPR018000 Neurotransmitter-gated ion-channel, conserved site
      IPR006202 Neurotransmitter-gated ion-channel ligand-binding domain
      IPR036734 Neurotransmitter-gated ion-channel ligand-binding domain superfamily
      IPR006029 Neurotransmitter-gated ion-channel transmembrane domain
      IPR036719 Neurotransmitter-gated ion-channel transmembrane domain superfamily
      IPR002394 Nicotinic acetylcholine receptor
    • GlyGen
      P04760 2 sites
    Molecular
    Reagents
    less
    • All nucleic 50
      Genomic 7
      cDNA 30
      Primer pair 8
      Other 5

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-1038, MGD-MRK-1070
    References
    more
    • Summaries
      All 117
      Developmental Gene Expression 21
      Gene Ontology 10
      Phenotypes 12
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:338268 Dos Santos M, et al., Opposing gene regulatory programs governing myofiber development and maturation revealed at single nucleus resolution. Nat Commun. 2023 Jul 19;14(1):4333
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory