Adh1 MGI Mouse Gene Detail - MGI:87921 - alcohol dehydrogenase 1 (class I)

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Adh1 Gene Detail

Symbol

Adh1
Name

alcohol dehydrogenase 1 (class I)
Synonyms

Adh-1, Adh1-e, Adh-1e, Adh-1-t, Adh1-t, Adh-1t, Adh1tl, ADH-AA, class I alcohol dehydrogenase

Feature Type

protein coding gene
IDs

MGI:87921
NCBI Gene: 11522
Alliance

gene page
Transcription Start Sites

20 TSS
Candidate for QTL

1 QTL

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Sequence Map

Chr3:137983346-137996459 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 64.16 cM
Mapping Data

15 experiments

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SNPs within 2kb

466 from dbSNP Build 142
Strain Annotations

18
PCR

1
RFLP

3

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates	Select Strains
C57BL/6J	MGI_C57BL6J_87921	protein coding gene	Chr3:137966752-137996459 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0027928	protein coding gene	Chr3:141313653-141343867 (+)
A/J	MGP_AJ_G0027885	protein coding gene	Chr3:136305524-136332885 (+)
AKR/J	MGP_AKRJ_G0027851	protein coding gene	Chr3:139932895-139960138 (+)
BALB/cJ	MGP_BALBcJ_G0027897	protein coding gene	Chr3:136112336-136139957 (+)
C3H/HeJ	MGP_C3HHeJ_G0027627	protein coding gene	Chr3:140256489-140283897 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0028341	protein coding gene	Chr3:146174047-146207938 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025679	protein coding gene	Chr3:131721847-131753089 (+)
CAST/EiJ	MGP_CASTEiJ_G0027083	protein coding gene	Chr3:140025902-140055877 (+)
CBA/J	MGP_CBAJ_G0027604	protein coding gene	Chr3:151142960-151170068 (+)
DBA/2J	MGP_DBA2J_G0027743	protein coding gene	Chr3:135425689-135453750 (+)
FVB/NJ	MGP_FVBNJ_G0027710	protein coding gene	Chr3:132885589-132914679 (+)
LP/J	MGP_LPJ_G0027853	protein coding gene	Chr3:142699034-142727550 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027742	protein coding gene	Chr3:159234027-159266559 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028399	protein coding gene	Chr3:139471445-139499808 (+)
PWK/PhJ	MGP_PWKPhJ_G0026807	protein coding gene	Chr3:135183439-135214219 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0026634	protein coding gene	Chr3:137577313-137606732 (+)
WSB/EiJ	MGP_WSBEiJ_G0027162	protein coding gene	Chr3:140313649-140346559 (+)

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Human Ortholog

ADH1A, alcohol dehydrogenase 1A (class I), alpha polypeptide

Vertebrate Orthologs

8

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ADH1A, alcohol dehydrogenase 1A (class I), alpha polypeptide
Synonyms

ADH1
Links

HGNC:249

NCBI Gene ID: 124

neXtProt AC: NX_P07327

UniProt: P07327
Chr Location

4q23; chr4:99276369-99291003 (-) GRCh38

Human Ortholog

ADH1B, alcohol dehydrogenase 1B (class I), beta polypeptide
Synonyms

ADH2, HEL-S-117
Links

HGNC:250

NCBI Gene ID: 125

neXtProt AC: NX_P00325

UniProt: P00325
Chr Location

4q23; chr4:99304971-99321401 (-) GRCh38

Human Ortholog

ADH1C, alcohol dehydrogenase 1C (class I), gamma polypeptide
Synonyms

ADH3
Links

HGNC:251

NCBI Gene ID: 126

neXtProt AC: NX_P00326

UniProt: P00326
Chr Location

4q23; chr4:99336497-99352746 (-) GRCh38

MGI Vertebrate Homology

Adh1 stringent orthology
3 human;1 mouse;1 rat;4 zebrafish
HCOP

vertebrate homology predictions: ADH1A, ADH1B, ADH1C
Gene Tree

Adh1

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Diseases

3 with human ADH1B,ADH1C associations

				Human Disease	Mouse Models
				alcohol dependence IDs alcohol dependence DOID:0050741 KEGG:05034 OMIM:103780
				late onset Parkinson's disease IDs late onset Parkinson's disease DOID:0060892 OMIM:168600 ORDO:411602
				pancreatic cancer IDs pancreatic cancer DOID:1793 DOID:14356 DOID:1797 DOID:3588 DOID:9859 ICD10CM:C25.0 ICD10CM:C25.1 ICD10CM:C25.2 ICD9CM:157.0 ICD9CM:157.1 ICD9CM:157.2 ICD9CM:157.8 KEGG:05212 MESH:D010190 NCI:C3305 ORDO:1333 ORDO:217074 UMLS_CUI:C0030297 UMLS_CUI:C0153458 UMLS_CUI:C0153459 UMLS_CUI:C0153460 UMLS_CUI:C0153463

Click on a disease name to see all genes associated with that disease.

References

1 with disease annotations

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Phenotype Summary

5 phenotypes from 2 alleles in 2 genetic backgrounds
3 phenotypes from multigenic genotypes
14 phenotype references

Phenotype Overview

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (other)

1
Endonuclease-mediated

1
Radiation induced

1
Targeted

7
Genomic Mutations

3 involving Adh1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

32 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygotes for targeted null mutations exhibit impaired metabolism of (and sensitivity to) ethanol and retinol.

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All GO Annotations

48
GO References

18

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1083
Tissues

268
cDNA Data

22
Literature Summary

19

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase adh1

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All Sequences

44
RefSeq

2
UniProt

3
CCDS

CCDS17867.1

Ensembl

ENSMUSG00000074207 (Evidence)
NCBI Gene

11522

Representative Sequences				Length	Strain/Species	Flank
	genomic	11522	NCBI Gene Model \| MGI Sequence Detail	13114	C57BL/6J	± kb
	transcript	NM_007409	RefSeq \| MGI Sequence Detail	1413	Not Specified
	polypeptide	P00329	UniProt \| EBI \| MGI Sequence Detail	375	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000004555 alcohol dehydrogenase 1

(term hierarchy)
EC

1.1.1.1
InterPro Domains

IPR013149 Alcohol dehydrogenase-like, C-terminal

IPR013154 Alcohol dehydrogenase-like, N-terminal

IPR002328 Alcohol dehydrogenase, zinc-type, conserved site

IPR011032 GroES-like superfamily

IPR036291 NAD(P)-binding domain superfamily

IPR020843 Polyketide synthase, enoylreductase domain
GlyGen

P00329 2 sites, 1 O-linked glycan (2 sites)

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All nucleic 40

Genomic 9

cDNA 24

Primer pair 6

Other 1

Microarray probesets 2

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MGD-MRK-1111, MGD-MRK-1112, MGD-MRK-1113, MGD-MRK-1115, MGD-MRK-1120, MGD-MRK-1121, MGD-MRK-1123, MGD-MRK-1124, MGI:2139643, MGI:87922, MGI:87924, MGI:87925

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Summaries

All 99

Developmental Gene Expression 19

Diseases 1

Gene Ontology 18

Phenotypes 14
Earliest

J:6249 Holmes RS, Genetics and ontogeny of alcohol dehydrogenase isozymes in the mouse: evidence for a cis-acting regulator gene (Adt-i) controlling C2 isozyme expression in reproductive tissues and close linkage of Adh-3 and Adt-i on chromosome 3. Biochem Genet. 1979 Jun;17(5-6):461-72
Latest

J:344098 Xu Z, et al., STOmicsDB: a comprehensive database for spatial transcriptomics data sharing, analysis and visualization. Nucleic Acids Res. 2024 Jan 5;52(D1):D1053-D1061

TSS for Adh1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr31954	Chr3:137983250-137983256 (+)	-93 bp
Tssr31955	Chr3:137983403-137983420 (+)	66 bp
Tssr31956	Chr3:137983509-137983518 (+)	168 bp
Tssr31957	Chr3:137983526-137983538 (+)	186 bp
Tssr31958	Chr3:137985545-137985569 (+)	2,211 bp
Tssr31959	Chr3:137986166-137986195 (+)	2,835 bp
Tssr31960	Chr3:137986218-137986231 (+)	2,879 bp
Tssr31961	Chr3:137988387-137988407 (+)	5,051 bp
Tssr31962	Chr3:137988526-137988537 (+)	5,186 bp
Tssr31963	Chr3:137988546-137988566 (+)	5,210 bp
Tssr31964	Chr3:137991035-137991070 (+)	7,707 bp
Tssr31965	Chr3:137992615-137992633 (+)	9,278 bp
Tssr31966	Chr3:137992665-137992687 (+)	9,330 bp
Tssr31967	Chr3:137994495-137994538 (+)	11,171 bp
Tssr31968	Chr3:137994541-137994586 (+)	11,218 bp
Tssr31969	Chr3:137994594-137994601 (+)	11,252 bp
Tssr31970	Chr3:137994605-137994617 (+)	11,265 bp
Tssr31971	Chr3:137995559-137995579 (+)	12,223 bp
Tssr31972	Chr3:137996329-137996340 (+)	12,989 bp
Tssr31973	Chr3:137996355-137996391 (+)	13,027 bp

Adh1 is Candidate Gene for:

QTL	Genetic Location*	Genome Location (GRCm39)	Reference	QTL Note
Cdcs1	Chr3, 56.07 cM	Chr3:126834882-126835005	J:109420	Microarray analysis was used to identify candidate genes for colitis susceptibility QTLs. Messenger RNA was analyzed for expression differences between colitis susceptible inbred strain C3H/HeJBir-Il10 and colitis resistant inbred strain C57BL/6J-Il10. Gbp2b (67.4 cM) on mouse Chromosome 3 is upregulated over 15-fold in C3H/HeJBir-Il10 animals. This candidate gene is known to be polymorphic between C3H/HeJBir and C57BL/6J and exhibits expression differences in these parental wildtype strains. Gbp1 maps to the Cdcs1 (cytokine deficiency colitis susceptibility 1) interval centered near 62 cM. Adh1 at 71.2 cM and Bglap2 at 42.6 cM also map to the same QTL interval. Adh1 is upregulated 1.5- to 2-fold, and Blgap2 is upregulated 2- to5-fold, in C3H/HeJBir-Il10animals.

*cM position of peak correlated region/marker

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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