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Adh7 Gene Detail
Summary
  • Symbol
    Adh7
  • Name
    alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
  • Synonyms
    Adh-3, Adh3, Adh3-e, Adh-3e, Adh3-t, Adh-3t, Adh4, Adt-1, IV ADH
  • Feature Type
    protein coding gene
  • IDs
    MGI:87926
    NCBI Gene: 11529
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:137923521-137939143 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 64.13 cM
  • Mapping Data
    39 experiments
Strain
Comparison
more
  • SNPs within 2kb
    561 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_87926
 protein coding gene Chr3:137903828-137939143 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027927
 protein coding gene Chr3:141265953-141281598 (+)
A/J MGP_AJ_G0027884
 protein coding gene Chr3:136261810-136277569 (+)
AKR/J MGP_AKRJ_G0027850
 protein coding gene Chr3:139884400-139900045 (+)
BALB/cJ MGP_BALBcJ_G0027896
 protein coding gene Chr3:136067019-136082664 (+)
C3H/HeJ MGP_C3HHeJ_G0027626
 protein coding gene Chr3:140211431-140227076 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028340
 protein coding gene Chr3:146124088-146141459 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025678
 protein coding gene Chr3:131677634-131693538 (+)
CAST/EiJ MGP_CASTEiJ_G0027082
 protein coding gene Chr3:139981969-139997704 (+)
CBA/J MGP_CBAJ_G0027603
 protein coding gene Chr3:151094653-151110298 (+)
DBA/2J MGP_DBA2J_G0027742
 protein coding gene Chr3:135381597-135397234 (+)
FVB/NJ MGP_FVBNJ_G0027709
 protein coding gene Chr3:132841755-132857400 (+)
LP/J MGP_LPJ_G0027852
 protein coding gene Chr3:142654964-142670593 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027741
 protein coding gene Chr3:159189416-159205045 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028398
 protein coding gene Chr3:139426450-139442079 (+)
PWK/PhJ MGP_PWKPhJ_G0026806
 protein coding gene Chr3:135138004-135153967 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026633
 protein coding gene Chr3:137528718-137544459 (+)
WSB/EiJ MGP_WSBEiJ_G0027161
 protein coding gene Chr3:140268264-140284515 (+)



Homology
more
  • Human Ortholog
    ADH7, alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
  • Vertebrate Orthologs
    6
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ADH7, alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
  • Synonyms
    ADH4
  • Links
    NCBI Gene ID: 131
    neXtProt AC: NX_P40394
    UniProt: P40394

  • Chr Location
    4q23; chr4:99412261-99435510 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Adh7 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 1 allele in 2 genetic backgrounds
    3 phenotypes from multigenic genotypes
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in defective ethanol clearance and reduced metabolism of retinal to retinoic acid.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    41
  • GO References
    17
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1026
  • Tissues
    197
  • cDNA Data
    24
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000055301 Ensembl Gene Model | MGI Sequence Detail 15623 C57BL/6J ±  kb
    transcript ENSMUST00000090171 Ensembl | MGI Sequence Detail 3432 Not Applicable  
    polypeptide ENSMUSP00000087633 Ensembl | MGI Sequence Detail 374 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 29
      Genomic 2
      cDNA 24
      Primer pair 2
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-1116, MGD-MRK-1117, MGD-MRK-1118, MGD-MRK-1125, MGD-MRK-1126, MGD-MRK-1127, MGD-MRK-1166, MGD-MRK-35651, MGI:107190, MGI:2139678, MGI:87927, MGI:87928
    References
    more
    • Summaries
      All 92
      Developmental Gene Expression 11
      Diseases 2
      Gene Ontology 17
      Phenotypes 15
    • Earliest
      J:5932 Holmes RS, The genetics of alpha-hydroxyacid oxidase and alcohol dehydrogenase in the mouse: evidence for multiple gene loci and linkage between Hao-2 and Adh-3. Genetics. 1977 Dec;87(4):709-16
    • Latest
      J:302829 Lu J, et al., Mouse models for human hyperuricaemia: a critical review. Nat Rev Rheumatol. 2019 Jul;15(7):413-426
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory