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Adra2b Gene Detail
Summary
  • Symbol
    Adra2b
  • Name
    adrenergic receptor, alpha 2b
  • Synonyms
    [a]2B, a2b-AR, Adra-2b, alpha2B
  • Feature Type
    protein coding gene
  • IDs
    MGI:87935
    NCBI Gene: 11552
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:127205128-127209141 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 61.95 cM
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    201 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_87935
 protein coding gene Chr2:127205099-127209141 (+)
129S1/SvImJ MGP_129S1SvImJ_G0026458
 protein coding gene Chr2:130653815-130657832 (+)
A/J MGP_AJ_G0026422
 protein coding gene Chr2:125349019-125353068 (+)
AKR/J MGP_AKRJ_G0026397
 protein coding gene Chr2:128927497-128931514 (+)
BALB/cJ MGP_BALBcJ_G0026434
 protein coding gene Chr2:125617606-125621617 (+)
C3H/HeJ MGP_C3HHeJ_G0026177
 protein coding gene Chr2:129443487-129447535 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026879
 protein coding gene Chr2:134742818-134746830 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024256
 protein coding gene Chr2:120190976-120195008 (+)
CAST/EiJ MGP_CASTEiJ_G0025638
 protein coding gene Chr2:129652516-129656566 (+)
CBA/J MGP_CBAJ_G0026157
 protein coding gene Chr2:139731715-139735772 (+)
DBA/2J MGP_DBA2J_G0026291
 protein coding gene Chr2:124758665-124762721 (+)
FVB/NJ MGP_FVBNJ_G0026255
 protein coding gene Chr2:123406536-123413812 (+)
LP/J MGP_LPJ_G0026396
 protein coding gene Chr2:130881872-130885910 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026275
 protein coding gene Chr2:143762730-143766747 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026934
 protein coding gene Chr2:128956613-128960641 (+)
PWK/PhJ MGP_PWKPhJ_G0025374
 protein coding gene Chr2:124304265-124308379 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025176
 protein coding gene Chr2:128035266-128039243 (+)
WSB/EiJ MGP_WSBEiJ_G0025712
 protein coding gene Chr2:129849816-129853821 (+)



Homology
more
  • Human Ortholog
    ADRA2B, adrenoceptor alpha 2B
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ADRA2B, adrenoceptor alpha 2B
  • Synonyms
    ADRA2L1, ADRA2RL1, ADRARL1, alpha-2BAR, ALPHA2BAR, FAME2
  • Links
    NCBI Gene ID: 151
    neXtProt AC: NX_P18089
    UniProt: P18089

  • Chr Location
    2q11.2; chr2:96112876-96116571 (-)  GRCh38
Human Diseases
more
  • Diseases
    5 with human ADRA2B associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    21 phenotypes from 2 alleles in 3 genetic backgrounds
    5 phenotypes from multigenic genotypes
    2 images
    32 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice exhibit poor survival and breeding, lack the vasoconstrictor response to alpha2-adrenergic receptor agonists, and display background strain dependent postnatal respiratory failure. Heterozygotes show an attenuated hypertensive response to subtotal nephrectomy and salt loading.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    40
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    773
  • Tissues
    50
  • cDNA Data
    14
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000058620 Ensembl Gene Model | MGI Sequence Detail 4014 C57BL/6J ±  kb
    transcript ENSMUST00000071902 Ensembl | MGI Sequence Detail 3936 Not Applicable  
    polypeptide ENSMUSP00000071798 Ensembl | MGI Sequence Detail 453 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 22
      Genomic 4
      cDNA 14
      Primer pair 4

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-1137, MGD-MRK-1141
    References
    more
    • Summaries
      All 84
      Developmental Gene Expression 9
      Gene Ontology 10
      Phenotypes 32
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:341722 Gonzatti MB, et al., Targeting adrenergic receptors to mitigate invariant natural killer T cells-induced acute liver injury. iScience. 2023 Oct 20;26(10):107947
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory