About   Help   FAQ
Afp Gene Detail
Summary
  • Symbol
    Afp
  • Name
    alpha fetoprotein
  • Synonyms
    alpha-foetoprotein
  • Feature Type
    protein coding gene
  • IDs
    MGI:87951
    NCBI Gene: 11576
  • Alliance
    gene page
  • Transcription Start Sites
    42 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:90638596-90656766 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 44.77 cM
  • Mapping Data
    50 experiments
Strain
Comparison
more
  • SNPs within 2kb
    660 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
  • RFLP
    10
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_87951
 protein coding gene Chr5:90638573-90656766 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029722
 protein coding gene Chr5:91570061-91590773 (+)
A/J MGP_AJ_G0029688
 protein coding gene Chr5:87949196-87967354 (+)
AKR/J MGP_AKRJ_G0029634
 protein coding gene Chr5:90816549-90836597 (+)
BALB/cJ MGP_BALBcJ_G0029698
 protein coding gene Chr5:88847994-88866148 (+)
C3H/HeJ MGP_C3HHeJ_G0029421
 protein coding gene Chr5:91233065-91253016 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030152
 protein coding gene Chr5:95232916-95254648 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027388
 protein coding gene Chr5:83676514-83694626 (+)
CAST/EiJ MGP_CASTEiJ_G0028831
 protein coding gene Chr5:90598517-90619772 (+)
CBA/J MGP_CBAJ_G0029391
 protein coding gene Chr5:98488337-98506482 (+)
DBA/2J MGP_DBA2J_G0029535
 protein coding gene Chr5:88031818-88051251 (+)
FVB/NJ MGP_FVBNJ_G0029494
 protein coding gene Chr5:86891872-86909982 (+)
LP/J MGP_LPJ_G0029623
 protein coding gene Chr5:91951668-91969586 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029523
 protein coding gene Chr5:103492315-103511442 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030186
 protein coding gene Chr5:90348592-90366770 (+)
PWK/PhJ MGP_PWKPhJ_G0028550
 protein coding gene Chr5:87088033-87106379 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028385
 protein coding gene Chr5:89752586-89770926 (+)
WSB/EiJ MGP_WSBEiJ_G0028910
 protein coding gene Chr5:90808130-90825959 (+)



Homology
more
  • Human Ortholog
    AFP, alpha fetoprotein
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AFP, alpha fetoprotein
  • Synonyms
    AFPD, FETA, HPAFP
  • Links
    NCBI Gene ID: 174
    neXtProt AC: NX_P02771
    UniProt: P02771

  • Chr Location
    4q13.3; chr4:73431138-73456174 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human AFP associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 2 alleles in 1 genetic background
    2 phenotypes from multigenic genotypes
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Females homozygous for targeted null mutations are sterile due to impairment of the hypothalamic/pituitary system and failure of the estrus cycle resulting in anovulation. Homozygous males are fertile.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1341
  • Tissues
    161
  • cDNA Data
    467
  • Literature Summary
    190
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000054932 Ensembl Gene Model | MGI Sequence Detail 18171 C57BL/6J ±  kb
    transcript ENSMUST00000042755 Ensembl | MGI Sequence Detail 2063 Not Applicable  
    polypeptide ENSMUSP00000041006 Ensembl | MGI Sequence Detail 605 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 550
      Genomic 24
      cDNA 473
      Primer pair 34
      Other 19

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-1173
    References
    more
    • Summaries
      All 309
      Developmental Gene Expression 190
      Gene Ontology 8
      Phenotypes 21
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:342334 Koike S, et al., The autotaxin-LPA axis promotes membrane trafficking and secretion in yolk sac visceral endoderm cells. Biol Open. 2023 Nov 15;12(11)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory