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Agrn
Gene Detail
 Symbol
Name
ID
Agrn
agrin
MGI:87961
Synonyms Agrin, nmf380, NMF380
Feature Type protein coding gene
Genetic Map
Chromosome 4
88.55 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr4:156165290-156197488 bp, - strand
From VEGA annotation of GRCm38

  32199 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:27907  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: agrin
Gene Tree: Agrn

Human
homologs
Human Homolog AGRN, agrin
NCBI Gene ID 375790
neXtProt AC  NX_O00468
Human Synonyms  CMSPPD
Human Chr (Location)  1p36.33; chr1:1020123-1056119 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human AGRN
Mutations,
alleles, and
phenotypes
All mutations/alleles(45) : Chemically induced (ENU)(1) Gene trapped(39) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Nullizygous mice display embryonic failure of NMJ formation, inability to breathe or move and perinatal lethality. Homozygotes for an ENU-induced allele show poor hindlimb motor control, myopathy, muscle atrophy, spasms and fiber-type switching, NMJ disaggregation, camptodactyly and premature death.
 
Human Diseases Modeled Using Mouse Agrn (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Agrn interacts with 220 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (55 annotations)
Process cell differentiation, multicellular organismal development, ...
Component axonal growth cone, basal lamina, ...
Function acetylcholine receptor regulator activity, BMP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (26 records)
Data Summary: Results (63)    Tissues (25)    Images (19)
Theiler Stages: 17, 20, 22, 24, 26, 28
Assay TypeResults
Immunohistochemistry 9
RNA in situ 18
Western blot 36
cDNA source data(383)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(387) Genomic(2) cDNA(384) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000011080 (Evidence)
Ensembl Gene ModelENSMUSG00000041936 (Evidence)
Entrez Gene11603 (Evidence)
UniGene273098
DFCITC1574714, TC1597868, TC1601048, TC1601749, TC1621503, TC1647471, TC1712317
DoTSDT.101739055, DT.492497, DT.528497, DT.91387187, DT.91436257, DT.94291521, DT.94350853
NIA Mouse Gene IndexU025890
PDB3PVE
Consensus CDS ProjectCCDS19060.2
International Mouse Knockout Project StatusAgrn
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000011080 VEGA Gene Model | MGI Sequence Detail 32199 C57BL/6J ±  kb
transcript OTTMUST00000112089 VEGA | MGI Sequence Detail 6891 Not Applicable 
polypeptide OTTMUSP00000062908 VEGA | MGI Sequence Detail 2034 Not Applicable 

For the selected sequences
All sequences(104) RefSeq(16) UniProt(13)
Polymorphisms RFLP(1) : SNPs within 2kb(286 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004850 Agrin NtA
InterPro IPR008985 Concanavalin A-like lectin/glucanases superfamily
InterPro IPR013320 Concanavalin A-like lectin/glucanase, subgroup
InterPro IPR013032 EGF-like, conserved site
InterPro IPR002049 EGF-like, laminin
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR003645 Follistatin-like, N-terminal
InterPro IPR002350 Kazal domain
InterPro IPR001791 Laminin G domain
InterPro IPR000082 SEA domain
InterPro IPR008993 Tissue inhibitor of metalloproteinases-like, OB-fold
Protein Ontology PR:000003845 agrin
References (Earliest) J:3071 Rupp F, et al., Structure and chromosomal localization of the mammalian agrin gene. J Neurosci. 1992 Sep;12(9):3535-44
(Latest) J:207976 Li Q, et al., The splicing regulator PTBP2 controls a program of embryonic splicing required for neuronal maturation. Elife. 2014;3:e01201
All references(116)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-1190, MGI:3614576

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory