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Agrn Gene Detail
Summary
  • Symbol
    Agrn
  • Name
    agrin
  • Synonyms
    Agrin, nmf380, NMF380
  • Feature Type
    protein coding gene
  • IDs
    MGI:87961
    NCBI Gene: 11603
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:156249747-156281945 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 88.55 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1389 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_87961
 protein coding gene Chr4:156249747-156281997 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029247
 protein coding gene Chr4:160535045-160567261 (-)
A/J MGP_AJ_G0029212
 protein coding gene Chr4:153769427-153801593 (-)
AKR/J MGP_AKRJ_G0029160
 protein coding gene Chr4:157959415-157992023 (-)
BALB/cJ MGP_BALBcJ_G0029228
 protein coding gene Chr4:154246527-154278746 (-)
C3H/HeJ MGP_C3HHeJ_G0028949
 protein coding gene Chr4:158529983-158562147 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029677
 protein coding gene Chr4:166233741-166265939 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026921
 protein coding gene Chr4:146046132-146078407 (-)
CAST/EiJ MGP_CASTEiJ_G0028361
 protein coding gene Chr4:155952609-155984771 (-)
CBA/J MGP_CBAJ_G0028911
 protein coding gene Chr4:171277343-171313208 (-)
DBA/2J MGP_DBA2J_G0029060
 protein coding gene Chr4:153789112-153821276 (-)
FVB/NJ MGP_FVBNJ_G0029023
 protein coding gene Chr4:153037386-153069572 (-)
LP/J MGP_LPJ_G0029150
 protein coding gene Chr4:160482208-160514369 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029050
 protein coding gene Chr4:174052905-174085134 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029709
 protein coding gene Chr4:158592939-158625103 (-)
PWK/PhJ MGP_PWKPhJ_G0028082
 protein coding gene Chr4:149932567-149964915 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027916
 protein coding gene Chr4:152843600-152875622 (-)
WSB/EiJ MGP_WSBEiJ_G0028441
 protein coding gene Chr4:158772931-158805133 (-)



Homology
more
  • Human Ortholog
    AGRN, agrin
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AGRN, agrin
  • Synonyms
    AGRIN, CMS8, CMSPPD
  • Links
    NCBI Gene ID: 375790
    neXtProt AC: NX_O00468
    UniProt: O00468

  • Chr Location
    1p36.33; chr1:1020120-1056119 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Agrn mouse models; 1 with human AGRN associations

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    35 phenotypes from 8 alleles in 12 genetic backgrounds
    3 phenotypes from multigenic genotypes
    53 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Nullizygous mice display embryonic failure of NMJ formation, inability to breathe or move and perinatal lethality. Homozygotes for an ENU-induced allele show poor hindlimb motor control, myopathy, muscle atrophy, spasms and fiber-type switching, NMJ disaggregation, camptodactyly and premature death.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    89
  • GO References
    34
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    920
  • Tissues
    86
  • cDNA Data
    384
  • Literature Summary
    43
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000041936 Ensembl Gene Model | MGI Sequence Detail 32199 C57BL/6J ±  kb
    transcript ENSMUST00000180572 Ensembl | MGI Sequence Detail 6891 Not Applicable  
    polypeptide ENSMUSP00000137931 Ensembl | MGI Sequence Detail 2034 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 401
      Genomic 2
      cDNA 385
      Primer pair 10
      Other 4

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-1190, MGI:3614576
    References
    more
    • Summaries
      All 172
      Developmental Gene Expression 43
      Diseases 1
      Gene Ontology 34
      Phenotypes 53
    • Earliest
      J:3071 Rupp F, et al., Structure and chromosomal localization of the mammalian agrin gene. J Neurosci. 1992 Sep;12(9):3535-44
    • Latest
      J:354621 Tu WY, et al., Local protein synthesis at neuromuscular synapses is required for motor functions. Cell Rep. 2024 Sep 24;43(9):114661
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory